Nanoparticle Contrast Agents - Methods and Applications

                  1806.    SPIO Positive Contrast In-Vivo by the Use of Diagonal-SPRITE

Andrea Protti¹, Po-Wah So¹, Amy Herlihy¹, Jimmy Bell¹

¹Hammersmith Hospital, Imperial College London, London, UK

                  1807.    Diffusion is a Major Determinant of Contrast in SSFP-Based Single Cell MRI:
                                A Theoretical and Experimental Study

Trevor Wade¹, Chris Heyn¹, ², Dave Rutt¹, Paula Foster¹, Brian Rutt¹

¹Robarts Research Institute, London, Ontario, Canada; ²University of Toronto, Toronto, Ontario, Canada

                  1808.    Phase Susceptibility-Weighted Imaging of SPIO Nanoparticles

Melanie S. Kotys¹, Steve H. Fung¹, Jianwu Xie¹, King CP Li¹

¹National Institutes of Health, Bethesda, Maryland, USA

                  1809.    Non-Monoexponential Signal Decay Due to Single SPIO Loaded Cells

Joerg Pintaske¹, Bernd Mueller-Bierl¹, Fritz Schick¹

¹University Hospital Tuebingen, Tuebingen, BW, Germany

                  1810.    LDL Nanoparticles as Magnetic Resonance Imaging Contrast Agents

Ian Ronald Corbin¹, Hui Li¹, Juan Chen¹, Jerry David Glickson¹, Gang Zheng¹

¹University of Pennsylvania, Philadelphia, Pennsylvania, USA

                  1811.    Numerical Simulation of Magnetic Field Distortions Caused by Cells Loaded with SPIO Nanoparticles

Joerg Pintaske¹, Bernd Mueller-Bierl¹, Fritz Schick¹

¹University Hospital Tuebingen, Tuebingen, BW, Germany

                  1812.    Detection of Blood Volume Changes in the Rat Kidney Using an Intravascular USPIO Contrast Agent

Pippa Storey¹, ², Lin Ji¹, Lu-Ping Li¹, Pottumarthi Vara Prasad¹, ²

¹Evanston Northwestern Healthcare, Evanston, Illinois, USA; ²Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA

                  1813.    MRI of Mouse Experimental Colitis Using Ultrasmall  Superparamagnetic Iron Oxide Particles

Anna E. Larsson¹, Silvia Melgar¹, Erika Rehnström¹, Lennart ET Svensson¹, Erik Michaelsson¹, Paul D. Hockings¹, Lars E. Olsson¹

¹AstraZeneca, Mölndal, Sweden

                  1814.    Comparison of T2 and T2* for Quantification of Cellular Iron-Uptake at 3.0 T

Hannes Dahnke¹, Rebecca Kuhlpeter², Lars Matuszewski², Walter L. Heindel², Tobias Schaeffter¹, Christoph Bremer²

¹Philips Research Laboratories, Hamburg, Germany; ²University Hospital Muenster, Muenster, Germany

                  1815.    Improving Contrast of Iron Oxide Based Cell Labeling with Manganese-Enhanced MRI

Ichio Aoki¹, ², Yuko Kawai¹, Jun-ichiro Jo³, Yasuhiko Tabata³, Masahiro Umeda¹, Toshihiro Higuchi¹,

Afonso C. Silva², Chuzo Tanaka¹

¹Meiji University of Oriental Medicine, Kyoto, Japan; ²NINDS, NIH, Bethesda, Maryland, USA; ³Kyoto University, Kyoto, Japan

                  1816.    Sensitivity of Off-Resonance Susceptibility Separation with Superparamagnetic Iron Oxide

Catherine Diane Gard¹, Anthony Z. Faranesh², Garry Gold², Tom Grist¹, Scott B. Reeder¹

¹University of Wisconsin-Madison, Madison, Wisconsin, USA; ²Stanford University, Stanford, California, USA

                  1817.    Positive Contrast Visualization of SPIO Labelled Cells by Diagonal-SPRITE

Po-Wah So¹, Andrea Protti¹, Tammy Kalber¹, Amy Heavner Herlihy¹, Jimmy David Bell¹

¹Hammersmith Hospital, Imperial College London, London, UK

                  1818.    Small Hypovascular Hepatocellular Nodules: Association with Signal Intensity at
                                SPIO-Enhanced MR Imaging in Cirrhotic Livers

Minoru Hayashida¹, Katsuyoshi Ito¹, Ayame Shimizu¹, Masahiro Tanabe¹, Naofumi Matsunaga¹

¹Yamaguchi University School of Medicine, Ube, Yamaguchi, Japan

                  1819.    Relaxometry of New Nanoparticles at 3 Tesla: Effect of Core Size and Coating on R1, R2, R2*

Michael Gerhard Kaul¹, Nadja Bigall², Oliver T. Bruns¹, Harald Ittrich¹, Marija S. Nikolic², Wolfgang J. Parak³, Hannes Dahnke⁴, Horst Weller², Gerhard Adam¹

¹University Medical Center Hamburg-Eppendorf, Hamburg, Germany; ²University of Hamburg, Hamburg, Germany; ³

Ludwig-Maximilians University, München, Germany; ⁴Philips Research Laboratories, Hamburg, Germany

                  1820.    New Synthesis Method of Ultrasmall Iron Oxide Nanoparticles Using Polyvinylpyrrolidone

Ji-ae Park¹, Yongmin Chang, ¹, Bo-Hyung Park¹, Seung-Tae Woo¹, Hui-Jin Song¹, Joo-Hyun Kim¹

¹Kyungpook National University, Daegu, Jung-gu, Republic of Korea

                  1821.    Distinguishing of Magnetically Labeled Cells from Hemorrhage Using Positive Contrast MRI

Eun-Ju Kim¹, Dae Hong Kim², Eun-Sook Lee¹, Ho-Taek Song¹, Jin-Suck Suh¹

¹Yonsei University, Seoul, Republic of Korea; ²Korea Basic Science Institute, Daejeon, Republic of Korea

                  1822.    MR Apoptosis Imaging and Evidence of Apoptotic Nanoprobe Passing Across the Blood Brain Barrier

Donghoon Lee¹, Jonathan Gunn¹, Conroy Sun¹, Omid Veiseh¹, Stacey Hansen², Miqin Zhang¹, Jim Olson²,

Richard Ellenbogen¹, Raymond Sze³

¹University of Washington, Seattle, Washington, USA; ²Fred Hutchinson Cancer Research Center, Seattle, Washington, USA; ³Children's Hospital and Regional Medical Center, Seattle, Washington, USA

                  1823.    Off Resonance Spectroscopic Imaging of Iron Oxide Nanoparticles at Dilute Concentrations
                                and High Field Strengths

Christian Thomas Farrar¹, Guangping Dai¹, Bruce R. Rosen¹, David E. Sosnovik¹

¹Massachusetts General Hospital, Charlestown, Massachusetts, USA

                  1824.    Epidermal Growth Factor Receptor (EGFR) Targeted MRI Using a Probe of SPIO Nanocrystal and
                                ScFv EGFR Conjugate

Hui Mao¹, Lily Yang¹, Xianghong Peng¹, Y Andrew Wang², Xiaoxia Wang¹, Zehong Cao¹, Gregory Adams³, Qing An Yuan³

¹Emory University School of Medicine, Atlanta, Georgia, USA; ²Ocean NanoTech, LLC, Fayetteville, Arkasas, USA; ³Fox Chase Cancer Center, Philadelphia, Pennsylvania, USA

                  1825.    Fast Positive Contrast Imaging Using a Spin-Echo Spiral Sequence

Weitian Chen¹, Wen-Tung Wang¹, Walter J. Rogers¹, Craig H. Meyer¹

¹University of Virginia, Charlottesville, Virginia, USA

                  1826.    Investigation of USPIO-Induced Field Inhomogeneities in a Rat Stroke Model

Ana-Maria Oros-Peusquens¹, Marco Irkens¹, Michael Schroeter², Andreas Saleh², Sebastian Jander², Nadim Jon Shah¹

¹Research Centre Juelich, Juelich, Germany; ²Heinrich-Heine University Duesseldorf, Duesseldorf, Germany

                  1827.    Magnetic Resonance Imaging of Viral Particle Biodistribution In Vivo

Juhana Hakumäki¹, ², Jani Räty¹, Timo Liimatainen¹, Thomas Wirth³, Tuulia Huhtala¹, Teemu Ihalainen⁴,

Maija Vihinen-Ranta⁴, Ale Närvänen¹, Seppo Ylä-Herttuala¹

¹University of Kuopio, Kuopio, Finland; ²Kuopio University Hospital, Kuopio, Finland; ³Ark Therapeutics Ltd., Kuopio, Finland; ⁴University of Jyväskylä, Jyväskylä, Finland

                  1828.    Temperature Dependence of T1 Relaxation Time of New Long-Circulating Thermosensitive Liposomes
                                with Encapsulated Gadodiamide

Tungte Wang¹, Martin Hossann¹, Herbert M. Reinl¹, Michael Peller¹, Nicole Teichert¹, Maximilian Reiser¹,

Rolf D. Issels¹, Lars H. Lindner¹

¹University Hospital Grosshadern, Ludwig-Maximilians-University, Munich, Bavaria, Germany

                  1829.    The Modified Fe₃O₄-NH₃⁺ with RGD-4C Ligand for Cancer Cell Targeting MR Contrast Agent

Chia-Hao Su¹, Ping-Ching Wu², Jun-Cheng Weng¹, Dar-Bin Shieh³, Chen-Sheng Yeh², Jyh-Horng Chen¹

¹National Taiwan University, Taipei, Taiwan; ²National Cheng Kung University, Tainan, Taiwan; ³National Cheng Kung University, Taipei, Taiwan

                  1830.    Targeted Contrast Using Gadolinium Labeled G5 Dendrimers

Scott D. Swanson¹, Jolanta F. Kukowska-Latallo¹, Anil K. Patri, ¹², James R. Baker, Jr. ¹

¹University of Michigan, Ann Arbor, Michigan, USA; ²National Cancer Institute, Frederick, Maryland, USA

                  1831.    Hot Spot Imaging of Microcapsules: An Initial Assessment of Detection with Fluorine and
                                Magnetization Transfer Imaging

Brad P. Barnett¹, Assaf A. Gilad¹, Jesus Ruiz-Cabello¹, Mike T. McMahon¹, ², Dara L. Kraitchman¹, Aravind Arepally¹, Peter C. van Zijl¹, ², Jeff W M Bulte¹

¹Johns Hopkins University School of Medicine, Baltimore, Maryland, USA; ²Kennedy Krieger Institute, Baltimore, Maryland, USA

                  1832.    Annexin A5 Conjugated Quantum Dots with a Paramagnetic Lipidic Coating for the Multimodal
                                 Detection of Apoptotic Cells

Geralda A.F. van Tilborg¹, Willem J.M. Mulder¹, Patrick T.K. Chin¹, Chris P.M. Reutelingsperger²,

Gustav J. Strijkers¹, Klaas Nicolay¹

¹Eindhoven University of Technology, Eindhoven, Netherlands; ²Maastricht University, Maastricht, Netherlands

                  1833.    Compartmental Assessment of Gadofluorine Contrast Agent Deposition in Atherosclerotic
                                Plaque of WHHL Rabbits and Its Correlation to Lipid Content

Stephen Clark Lenhard¹, Karpagam Aravindham¹, Alan Olzinski¹, Bernd Misselwitz², Hanns Joachim Weinmann²,

Beat Jucker¹

¹GlaxoSmithKline, King of Prussia, Pennsylvania, USA; ²Schering AG, Berlin, Germany, Germany

                  1834.    ¹⁹F MR Techniques Augment Quantitative Molecular Imaging with Paramagnetic Perfluorocarbon
                                Nanoparticles at 1.5T

Shelton D. Caruthers¹, ², Anne M. Neubauer¹, ³, Frank D. Hockett¹, Rolf Lamerichs⁴, Patrick M. Winter¹,

Michael J. Scott¹, Patrick J. Gaffney⁵, Samuel A. Wickline¹, Gregory M. Lanza¹

¹Washington University School of Medicine, St. Louis, Missouri, USA; ²Philips Medical Systems, Andover, Massachusetts, USA; ³Washington University, St. Louis, Missouri, USA; ⁴Philips Research Labs, Eindhoven, Netherlands; ⁵St. Thomas' Hospital, London, UK

                  1835.    The Optimization of Liposomal Formulations for Molecular MR Imaging

Gustav Jacob Strijkers¹, Willem J. Mulder¹, Ewelina Kluza¹, Klaas Nicolay¹

¹Eindhoven University of Technology, Eindhoven, -, Netherlands

                  1836.    A Novel Approach of Quantifying Susceptibilities in Small Objects: Quantitative Diagnosis in MRI

Ching-Yi Hsieh¹, Yu-Chung Norman Cheng¹, Jaladhar Neelavalli¹, Qiang Liu¹, E. Mark Haacke¹

¹Wayne State University, Detroit, Michigan, USA

New or SMART Contrast Agents

                  1837.    CNS Imaging with a High Relaxivity Contrast Agent: What is the Benefit Over a Standard Gadolinium Agent?

Kenneth R. Maravilla¹, Joseph A. Maldjian², Ilona M. Schmalfuss³, Matthew J. Kuhn⁴, Nicoletta Anzalone⁵,

Marco Essig⁶, Lars Gustafsson⁷

¹University of Washington, Seattle, Washington, USA; ²Wake Forest University, Winston-Salem, North Carolina, USA; ³University of Florida, Gainesville, Florida, USA; ⁴Southern Illinois School of Medicine, Springfield, Illinois, USA; ⁵Hospital San Raffaele, Milan, Italy; ⁶German Cancer Research Institute, Heidelberg, Germany; ⁷Sahlgrenska University Hospital, Gothenburg, Sweden

                  1838.    Development of Gadolinium Based Contrast Agents to Detect Tumor Apoptosis In Vivo Using MRI

Anant Krishnan¹, Andre Neves¹, Mikko Kettunen¹, De-en Hu¹, Maaike de Backer¹, Kevin Michael Brindle¹

¹University of Cambridge, Cambridge, UK

                  1839.    MRI Detection of Rapamycin and AP-Cav Therapeutic Rescue from Endothelial Over
                                Expression of Akt in Transgenic Mice

Keren Ziv¹, Thuy L. Phung², Ori Brenner¹, Kenneth Walsh³, Laura E. Benjamin⁴, Michal Neeman¹

¹Weizmann Institute of Science, Rehovot, Israel; ²Beth Israel Deaconess Medical Center  and Harvard Medical School, Boston, Massachusetts, USA; ³Boston University, Boston, Massachusetts, USA; ⁴Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, USA

                  1840.    Cellular MRI Contrast Via Co-Expression of Transferrin Receptor and Ferritin

Abby E. Deans¹, Youssef Zaim Wadghiri¹, Lisa M. Bernas², Xin Yu¹, Brian K. Rutt², Daniel H. Turnbull¹

¹New York University School of Medicine, New York, USA; ²University of Western Ontario, London, Ontario, Canada

                  1841.    The Efficacy of Signal Intensity Change Map Images Obtained Using First Pass Dynamic
                                Fercarbotran-Enhanced MR Imaging for Assessment of Focal Hepatic Lesion Vascularity

Seishi Kumano¹, Keiichi Kikuchi¹, Takaharu Tsuda¹, Hitoshi Miki¹, Teruhito Mochizuki¹

¹Ehime University, Toon, Ehime, Japan

                  1842.    Non-Invasive Visualization on Drug Delivery of Polymer Drug Conjugates

Furong Ye¹, Tianyi Ke¹, Eun-Kee Jeong¹, Xuli Wang¹, Zheng-Rong Lu¹

¹University of Utah, Salt Lake City, Utah, USA

                  1843.    Controlled Internalization and Recycling of Her-2/neu by Cross-Linking with an Avidin/streptavidin-Biotin
                                System for MR Enhancement

Wenlian Zhu¹, Baasil Okollie¹, Zaver M. Bhujwalla¹, Dmitri Artemov¹

¹Johns Hopkins University, Baltimore, Maryland, USA

                  1844.    Development of Avidin-Based Positive Contrast Agents to Detect Tumor Apoptosis Using MRI

Andre A. Neves¹, Anant Krishnan¹, Mikko Kettunen¹, De Hu¹, Maaike De-Backer¹, Kevin Brindle¹

¹University of Cambridge, Cambridge, England, UK 

                  1845.    MRI of C6 Glioma Cells Taged with an Opioid Functionalized DTPA-Gd Contrast Agent

Timo Dansauer¹, ², Ekkehard Küstermann¹, ², Dieter Leibfritz¹, ²

¹University of Bremen, Bremen, Germany; ²Center of Advanced Imaging (CAI), Bremen, Germany

                  1846.    Contrast Agent for Blood Pool Imaging and Targeted Contrast Delivery Using RHA and Gd-DTPA

Jim M. Wild¹, John Woodrow², Bernd Misselwitz³, Richard Johnson²

¹University of Sheffield, Sheffield, Yorkshire, UK; ²Upperton Ltd, Nottingham, UK; ³Schering, AG, Berlin, Germany

                  1847.    Design and Synthesis of a Novel Gadolinium-Based MR Contrast Gd(DOBAPATA) for MR Imaging of Calcium

Anil K. Mishra¹, Josef Pfeuffer²

¹INMAS, Delhi, India; ²Siemens Medical Solutions, Erlangen, Germany

                  1848.    Selective MRI and MRS of PEGylated Compounds

Scott D. Swanson¹

¹The University of Michigan, Ann Arbor, Michigan, USA

                  1849.    First In Vivo Characterization of a Low Molecular Weight Gd-Metallostar – a Contrast Agent with High Relaxivity

Claudia Weidensteiner¹, Joao Bruno Livramento², Philipp Schmidt¹, Rainer Kneuer¹, Peter Roland Allegrini¹,

Lothar Helm², Éva Tóth², ³, André E. Merbach²

¹Novartis Institutes for BioMedical Research, Basel, Switzerland; ²École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland; ³Centre de Biophysique Moléculaire CNRS, Orleans, France

                  1850.    Novel Bioresorbable Magnetic Contrast Agent Nanoceramics

Igor Kuriashkin¹, Louise Lee¹, Ryan Haggerty¹, Waltraud Kriven¹

¹University of Illinois  at Urbana-Champaign, Urbana, Illinois, USA

                  1851.    WITHDRAWN

                  1852.    Design and Synthesis of Novel Myristoylated Polyarginine Peptides for In Vivo Molecular Neuroimaging

Wellington Pham¹, Rob J.A. Nabuurs¹, Mark A. Van Buchem¹, Anna Moore¹

¹Massachusetts General Hospital, Charlestown, Massachusetts, USA

                  1853.    Paramagnetic Metal Probes Used for the Development of High-Relaxivity Protein Targeted Contrast Agents

Stephan G. Zech¹, Hariett B. Eldredge¹, Mark P. Lowe², Peter Caravan¹

¹EPIX Pharmaceuticals, Inc., Cambridge, Massachusetts, USA; ²University of Leicester, Leicester, UK

                  1854.    Comparison of Gd-Bz-TTDA, Gd-EOB-DTPA and Gd-BOPTA in Dynamic MR Imaging of the
                                Liver with Rat Models

Twei-Shiun Jaw¹, Gin-Chung Liu¹, Yun-Ming Wang¹, Shih-Hsien Chen¹, Jui-Shung Hsu¹, Feng-O Shen¹

¹Kaohsiung Medical University, Kaohsiung, Taiwan, Taiwan.

                  1855.    Transcription MRI Contrast Probe Enables the Detection of Different Cerebral Messenger RNA Levels

Shuning Huang¹, Christina H. Liu², Guangping Dai³, Bruce R. Rosen¹, Philip K. Liu³

¹MIT/MGH, Cambridge, Massachusetts, USA; ²Martinos Center for Biomedical Imaging, MGH, Cambridge, Massachusetts, USA; ³Martinos Center for Biomedical Imaging, MGH, Charlestown, Massachusetts, USA

                  1856.    Ferritin as a Tissue Specific MRI Reporter of Inducible Gene Expression in Transgenic Mice

Keren Ziv¹, Batya Cohen¹, Vyacheslav Kalchenko¹, Alon Harmelin¹, Michal Neeman¹

¹Weizmann Institute of Science, Rehovot, Israel

                  1857.    Transcription MRI Detects Altered Cerebral Gene Expression in Live Stroke Animals

Christina H. Liu¹, Shuning Huang, ¹², Bruce R. Rosen¹, Philip K. Liu¹

¹Massachusetts General Hospital, Charlestown, Massachusetts, USA; ²Massachusetts Institute of Technology, Cambridge, Massachusetts, USA 
 

                  1858.    Redox-Sensitive Contrast Agents for MRI Based on Reversible Binding of Thiols to Serum Albumin

Natarajan Raghunand¹, Bhumasamudram Jagadish¹, Theodore P. Trouard¹, Robert J. Gillies¹, Eugene A. Mash¹

¹University of Arizona, Tucson, Arizona, USA 

                  1859.    A Bio-Activated Paramagnetic Gd(III) Complex [Gd(DO3A-FPG)] for MRI

Yun-Ming Wang¹, Yu-Ton Chang¹, Yu-Zheng Su¹, Jui-Sheng Hsu¹, Gin-Chung Liu¹

¹Kaohsiung Medical University, Kaohsiung, Taiwan

                  1860.    Investigations Into the Relaxivity and Complexation Behaviour of GdDOTA-4AmP,
                                a PH Responsive MRI Contrast Agent

A. Dean Sherry¹, ², Mark Woods³, Paul Jurek³, Ferenc Kalaman¹, Md Meser Ali¹

¹University of Texas at Dallas, Richardson, Texas, USA; ²UT Southwestern Medical Center, Dallas, Texas, USA; ³Macrocyclics, Dallas, Texas, USA

                  1861.    A Smart PARACEST MRI Contrast Agent for Nitric Oxide Detection

Guanshu Liu¹, Marty D. Pagel²

¹Case Western Reserve University, Cleveland, Ohio, USA; ²Biomedical Engineering, Cleveland, Ohio, USA

                  1862.    A “smart” PARACEST Agent for Detection of Transglutaminase Activity

Rachel Rosenblum¹, Mark Pagel¹

¹Case Western Reserve University, Cleveland, Ohio, USA

                  1863.    A Transcatheter MR-Guided Fiber Optical Confocal Microscopy System

Sascha Krueger¹, Daniel Herzka², Charlotte Cavé³, King Li⁴, Steffen Weiss¹

¹Philips Research, Hamburg, Germany; ²Philips Research, Briarcliff Manor, New York, USA; ³Mauna Kea Technologies, Paris, France; ⁴National Institutes of Health, Bethesda, Maryland, USA

Cell Labeling and Tracking: Methods and Applications

                  1864.    Optimization of a Cell Labeling Strategy for Magnetic Resonance Imaging

Gunter Wolf¹, Klaus Strobel², Susanne Gruener¹, Arne Koch¹, Volker Hietschold³, Nasreddin Abolmaali¹

¹TU Dresden, Dresden, Germany; ²FZ Rossendorf, Dresden, Germany; ³University Hospital, Dresden, Dresden, Germany

                  1865.    In Vivo MR Imaging of the Sequential Recruitment of Macrophages to the Soft Tissue Infection

Jin Seong Lee¹, Hee Jung Kang², Heun-Don Jung³, Keun Ho Lim³, Sang Tae Kim³, Tae-Hwan Lim¹

¹University of Ulsan College of Medicine, Asan Medical Center, Seoul, Republic of Korea; ²Hallym University College of Medicine, Seoul, Republic of Korea; ³University of Ulsan College of Medicine, Seoul, Republic of Korea

                  1866.    Cellular Imaging of Rat Aortic Endothelial Cell Monolayer Using a 3T Whole Body Scanner

Frank Seifert¹, Isabela Schmitt-Knosalla², Martina Seifert²

¹Physikalisch-Technische Bundesanstalt, Berlin, Germany; ²Charité Universitätsmedizin Berlin, Berlin, Germany

                  1867.    Developing Magnetocapsules for Immunoprotection and MR Tracking of Pancreatic Islets
                                Using Clinically Approved Materials

Brad P. Barnett¹, Piotr Walczak¹, Wesley Gilson¹, Assaf A. Gilad¹, Jesus Ruiz-Cabello¹, Carolyn Lauzon¹,

Dara L. Kraitchman¹, Matthias Stuber¹, Aravind Arepally¹, Jeff WM Bulte¹

¹Johns Hopkins University School of Medicine, Baltimore, Maryland, USA

                  1868.    Antibody Mediated Cell Labeling of Peripheral T Cells with Micron Sized Iron Oxide Particles (MPIOs)
                                Allows Single Cell Detection by MRI

Erik M. Shapiro¹, ², Laura N. Medford-Davis², Cynthia E. Dunbar³, Alan P. Koretsky²

¹New York University School of Medicine, New York, New York, USA; ²National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, USA; ³National Heart, Lung and Blood Institute, Bethesda, Maryland, USA

                  1869.    Optimization of Dendritic Cell Labeling for MR Tracking After Vaccination in Cancer Patients

Pauline Verdijk¹, Tom W.J. Scheenen¹, Andor A. Veltien¹, Jeff W.M. Bulte², Piotr Walczak², W. Joost Lesterhuis¹,

I. Jolanda M. de Vries¹, Cornelis J.A. Punt¹, Arend Heerschap¹, Carl G. Figdor¹

¹Radboud University Nijmegen Medical Center, Nijmegen, Netherlands; ²Johns Hopkins University School of Medicine, Baltimore, Maryland, USA

                  1870.    Chemical Biotinylation of Cells for Molecular Imaging and Cell Tracking

Po-Wah So¹, Tammy Kalber¹, Amy Heavner Herlihy¹, Jimmy David Bell¹

¹Hammersmith Hospital, Imperial College London, London, UKd.

                  1871.    In Vitro Evaluation of Cellular Engraftment Parameters of 3 Transfection Methods to Label Mouse
                                Embryonic Stem Cells Using Ferumoxides

Yoriyasu Suzuki¹, Charles Henry Cunningham¹, Micha Drukker¹, Phillip Chung Ming Yang¹

¹Stanford University, Stanford, California, USA

                  1872.    Compatibility of Iron Nanoparticle-Based MRI Cell Tracking and ³¹P MRS Bioenergetic Measurements

Zhuoli Zhang¹, Kenneth W. Fishbein¹, Chiara Dell'Agnola¹, Steven J. Sollott¹, Kenneth R. Boheler¹, Magdalena Juhaszova¹, Edward G. Lakatta¹, Richard G. Spencer¹

¹National Institutes of Health, Baltimore, Maryland, USA

                  1873.    In Situ and In Vivo Magnetic Resonance Imaging of Iron Labelled Dendritic Cells in the Mouse

Andreas Hess¹, Dirk Baumjohann², Manfred B. Lutz², Kay Brune³, Lubos Budinsky¹

¹Institute of Pharmacology, FAU, Erlangen-Nürnberg, Germany; ²University Medical Center, Dep. Dermatology, Erlangen-Nürnberg, Germany; ³Doerenkamp Professorship for Innovations in Animal and Consumer Protection, FAU, Erlangen-Nürnberg, Germany

                  1874.    MRI Tracking of Migration of Bone Marrow Cells to the Sites of Injured Arteries

Bensheng Qiu¹, Fabao Gao¹, Sourav Kar¹, Jiangyang Zhang¹, Piotr Walczak¹, Malika Larabi¹, Rong Xue¹,

Emma Frost¹, Zhiping Qian¹, Jeff WM Bulte¹, Xiaoming Yang¹

¹Johns Hopkins Univ School of Medicine, Baltimore, Maryland, USA

                  1875.    Temporal Monitoring of an SPIO Labeled, Optically Traceable Tumor Mouse Model

Daniel A. Herzka¹, Jade Quijano², Terence Wong², Wei Liu¹, Jianwu Xie², King C. Li²

¹Philips Research North America, Bethesda, Maryland, USA; ²National Institutes of Health Clinical Center, Bethesda, Maryland, USA

                  1876.    The Efficacy of SPIO-Enhanced MRI in Evaluating Inflammatory Pseudotumors:
                                Imaging and Histopathological Correlation

Yasutaka Kawamura¹, Makoto Ishida¹, Akio Yamaguchi¹, Harumi Itoh¹

¹University of Fukui Hospital, Fukui, Japan

                  1877.    In Vivo Tracking of Endothelial Progenitor Cells in a Mouse Model of Choroidal Neovascularization

Sergio Li Calzi¹, Kyung-Hee Chang¹, Kyle Padgett¹, Aqeela Afzal¹, Lynn C. Shaw¹, Maria B. Grant¹, John R. Forder¹

¹University of Florida, Gainesville, Florida, USA

                  1878.    Long Term MR Signal Characteristics of Ferucarbotran-Labeled Mesenchymal Stem Cells:
                                Discrimination of Intra- And Extracellular Iron Oxides Before and After Cell Lysis

Tobias Daniel Henning¹, Jan S. Bauer¹, Thomas Frenzel², Elizabeth J. Sutton¹, Yanjun Fu¹, Heike E. Daldrup-Link¹

¹UCSF, San Francisco, California, USA; ²Schering AG, Berlin, Germany

                  1879.    Single Cell MRI with FIESTA: Quantitative Benefits of 3T Vs 1.5T

Soha Ramadan¹, Chris Heyn¹, Brian K. Rutt¹, Paula Foster¹

¹Robarts Research Institute, London, Ontario, Canada

 

                  1880.    MR Microscopy of Multipotent Astrocytic Stem Cells Labeled with Multimodal Qdots
                                Applied to a Neonatal Murine Model of Hypoxic Ischemic Encephalopathy

Samuel Colles Grant¹, ², Tong Zheng³, ⁴, Gregory P. Marshall II³, ⁴, Heesun Yang³, Debamitra Dutta³,

Heather Cornnell³, Swadeshmukul Santra⁵, Paul H. Holloway³, Brij M. Moudgil³, Edward W. Scott³, ⁴,

Eric D. Laywell³, ⁴, Glenn A. Walter³, Arthur Scott Edison, ²³, Dennis A. Steindler³, ⁴, Michael D. Weiss³

¹Florida State University, Tallahassee, Florida, USA; ²National High Magnetic Field Laboratory, Tallahassee, Florida, USA; ³University of Florida, Gainesville, Florida, USA; ⁴McKnight Brain Institute, Gainesville, Florida, USA; ⁵University of Central Florida, Orlando, Florida, USA

                  1881.    Imaging of Islet Transplantation in a Pre-Clinical Animal Model Using an FDA-Approved
                                Contrast Agent: In Vitro Studies

Natalia Evgenov¹, John Pratt¹, Zdravka Medarova¹, Pamela Pantazopoulos¹, Susan Bonner-Weir², Anna Moore¹

¹Massachusetts General Hospital, Charlestown, Massachusetts, USA; ²Joslin Diabetes Center, Boston, Massachusetts, USA

                  1882.    MR Characterization of Isolated Human Pancreatic Islets

Suraj Serai¹, Lara Leoni², Muhammed Haque², Jose Oberholzer¹, Richard Magin¹, Brian Roman²

¹University of Illinois at Chicago, Chicago, Illinois, USA; ²University of Chicago, Chicago, Illinois, USA

                  1883.    Comparison of Labeling Strategies for Stem Cells with Gd-Chelates

Tessa Geelen¹, Uwe Himmelreich¹, Carles Justicia¹, Cordula Strecker¹, Mathias Hoehn¹

¹Max-Planck-Institute for Neurological Research, Cologne, Germany

                  1884.    Positive Contrast Imaging of Iron-Oxide Labeled Human Embryonic Stem (HES) Cell and Fibroblast Using SWEET

Young Beom Kim¹, Hyen Suk Kim², Dae Kee Kwon², Seung-Schik Yoo³, Byeong Chun Lee², Sung Keun Kang²,

Woo Suk Hwang², HyunWook Park¹

¹Korea Advanced Institute of Science and Technology, Yuseong-Gu, Daejeon, Republic of Korea; ²Seoul National University, Gwanak-Gu, Seoul, Republic of Korea; ³Harvard Medical School, Boston, Massachusetts, USA

                  1885.    Tuftsin-Gd-DOTA Conjugates as Potential MRI Reagents for Macrophage Imaging

Jianghua Feng¹, Marco Meloni¹, Stuart Allan¹, Johanna Narvainen¹, Stephen Faulkner¹, Risto Kauppinen²

¹University of Manchester, Manchester, UK; ²University of Birmingham, Birmingham, UK

                  1886.    A Responsive MRI Contrast Agent to Monitor Functional Cell Status: A Feasibility Study Using Dendritic Cells

Uwe Himmelreich¹, Carles Justicia¹, Silvio Aime², Thomas Hieronymus³, Martin Zenke³, Mathias Hoehn¹

¹Max-Planck-Institute for Neurological Research, Cologne, Germany; ²University of Torino, Torino, Italy; ³RWTH Aachen, Aachen, Germany

                  1887.    Intracellular MR Contrast Agents Based on Cationic Cell Penetrating Peptides: A Comparative Study

Joern Engelmann¹, Wu Su¹, Deepti Jha¹, Ritu Mishra¹, Josef Pfeuffer¹, ², Kamil Ugurbil¹, ³

¹Max Planck Institute for Biological Cybernetics, Tuebingen, Baden-Wuerttemberg, Germany; ²Siemens Medical Solutions, Erlangen, Bayern, Germany; ³Center for Magnetic Resonance Research, Minneapolis, Minnesota, USA

                  1888.    A Novel Dual-Modality MRI/PET Probe

Björn Gustafsson¹, Angelique Y. Louie¹

¹University of California, Davis, Davis, California, USA

                  1889.    Identification of the Neural Stem Cells in the Human Brain by Magnetic Resonance Spectroscopy

Louis Manganas¹, Sherry Zhang¹, Petar Djuric¹, Mark Wagshul¹, Mirjana Maletic-Savatic¹

¹Stony Brook University, Stony Brook, New York, USA

                  1890.    Does Endocytosis of Perfluorocarbon Nanoparticles by Progenitor/Stem Cells Alter 19F Relaxation at 11.7T?

Divya Venkataramani¹, Junjie Chen¹, Anne Morawski Neubauer¹, Kathy Crowder¹, Jason Brant¹, Gregory M. Lanza¹, Samuel A. Wickline¹

¹Washington University, St. Louis, Missouri, USA

                  1891.    Dual Modality Monitoring of Intracerebral Stem Cell Delivery and Distribution Following Reperfused Ischemia

Piotr Walczak¹, Jian Zhang¹, Assaf A. Gilad¹, Dorota A. Kedziorek¹, Jesus Ruiz-Cabello¹, Randell G. Young²,

Mark F. Pittenger², Peter C.M van Zijl, ¹³, Judy Huang¹, Jeff W. Bulte¹

¹Johns Hopkins University, Baltimore, Maryland, USA; ²Osiris Therapeutics, Inc., Baltimore, Maryland, USA; ³Kennedy Krieger Institute, Baltimore, Maryland, USA

                  1892.    Superparamagnetic Iron Oxide Labelling for In Vivo Follow-Up of HRPE Cell Implants in Non-Human Primate

Joseph Flores¹, Alex L. MacKay², John R. O'Kusky³, Piotr Kozlowski², Joseph A. Frank⁴, Doris J. Doudet¹

¹Pacific Parkinson’s Research Centre, Vancouver, BC, Canada; ²High Field MRI Centre at UBC, Vancouver, BC, Canada; ³University of British Columbia, Vancouver, BC, Canada; ⁴National Institutes of Health, Bethesda, Maryland, USA