This one-day course will provide an introduction to important clinical needs and experimental techniques that inform on molecular processes that contribute to the development of the cancer phenotype. Measurement methods (including instrumentation, associated laboratory or clinical assessments) that interrogate deranged molecular and physiological processes at different length scales will be explained. The approaches demonstrated will be relevant to diagnosis, for the assessment of tumor aggressiveness, therapy response and resistance and will be relevant to the development of novel anti-cancer therapeutics.
Upon completion of this course, participants should be able to:
• Describe how MRS can demonstrate the regulation of important pathways in cell and xenograft models of cancer and how choline MRS is affected by the
cancer phenotype and treatment;
• Describe clinical applications of MR spectroscopy and barriers to full implementation;
• Explain methodologies, clinical uses, research applications and translation challenges of MR angiogenesis imaging methods;
• Describe mechanism for and importance of tumor hypoxia; discuss common methods of assessment including using MR & PET; and future hypoxia
biomarker development steps;
• Explain how diffusion measurements can provide information on cancer in experimental models and in patients, and how diffusion may change with treatment; and
• Describe how MAS can be used to asses tumors; and
• Identify likely MR detectable changes resulting from apoptosis
This course is designed for:
• Attendees with degree level education in physical, biological or medical sciences, interest in cancer, drug development,
biomarkers, and who are currently involved in research training, practice, or clinical training or practice.