| Sunrise
Course: |
| Mobile Lipids in Disease |
| Organizers:
Carles Arús, Ph.D. and Edward J. Delikatny, Ph.D. |
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| Skill Level: Advanced |
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| Tuesday, 21 April 2009 -
Friday, 24 April 2009 |
| 07:00 - 08:00 |
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| OVERVIEW |
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This course of four one hour sessions will consist of 2 or 3
lectures each morning followed by a discussion. Most
speakers will be from the NMR field with expertise in
detection and interpretation of the NMR visible mobile lipid
(ML) region of the 1H NMR spectrum, in humans and in cell
and animal models of human disease. Additional speakers will
be drawn from the field of lipid metabolism and lipid
droplet dynamics. The topics will range from the biochemical
and subcellular origin of ML, the dynamics of ML inside
cells, their NMR measurable biophysical parameters, in model
systems, cells, biopsies and in vivo, and finally the
correlation between their MRS observable changes in vivo and
disease detection and diagnosis (cancer, diabetes, liver
disease). |
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| EDUCATIONAL OBJECTIVES
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Upon completion of this
case based session, participants should be able to:
- Recognize the various ML resonances detectable
in the 1H NMR spectral
pattern of a tissue or organ;
- Select optimal acquisition conditions to detect ML
resonances and appreciate
their possible variation in biological samples;
- Describe the possible biochemical origins of ML;
- List possible causes for qualitative and quantitative
changes in the ML pattern;
- Interpret qualitative and quantitative changes in the ML
pattern of cells and
tissues; and
- List possible clinical applications of in vivo ML
detection for disease diagnosis,
staging and response to therapy.
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| Tuesday, 21 April 2009 |
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Mobile Lipids (ML) from the
Cellular Point of View |
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| 07:00 |
MRS Resonances as
Indicators of Altered Phospholipid and
Neutral Lipid Metabolism in Living Cells |
Franca Podo, D.Sc. |
| 07:20 |
Mobile Lipids and
Apoptosis |
Kevin M.
Brindle, D.Phil. |
| 07:40 |
Dynamics of NMR Visible Mobile
Lipids in Cultured Cells |
Carles Arús, Ph.D. |
| 08:00 |
Adjournment |
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| Wednesday, 22 April
2009 |
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ML Compartment
Studies in Model Systems, Cells and in vivo
by NMR and Other Methods |
| 07:00 |
Mobile Lipid
Accumulation as Stress Response |
Edward
J. Delikatny, Ph.D. |
| 07:20 |
ML in Model Systems
and Plasma/Serum: Micelles, Lipoproteins |
Alkystis
Phinikaridou, M.S. |
| 07:40 |
Relaxation and
Diffusion Measurements in vitro, ex vivo and
in vivo |
Chantal Rémy, Ph.D. |
| 08:00 |
Adjournment |
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Thursday, 23 April 2009 |
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Cancer,
Brain, and Other |
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| 07:00 |
Animal
Studies |
Risto A.
Kauppinen, M.D., Ph.D. |
| 07:30 |
Clinical Studies
|
Martin O. Leach, Ph.D. |
| 08:00 |
Adjournment |
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| Friday, 24 April
2009 |
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Muscle (IMCL and EMCL),
Heart, Liver, Diabetes |
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| 07:00 |
Muscle. IMCL, EMCL
and Muscle Metabolism in vivo |
Chris Boesch, M.D., Ph.D. |
| 07:20 |
Lipotoxicity, Diabetes, Steatosis, Steatohepatitis
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Preclinical Animal Models |
Rheal Antoine Towner, Ph.D. |
| 07:40 |
Clinical. Heart,
Liver, Diabetes |
Linda S. Szczepaniak,
Ph.D. |
| 08:00 |
Adjournment |
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