| Weekend Educational Course:
|
| Probing Cancer I:
Molecular Pathways to Experimental Models |
| Organizers:
Carles Arús, Ph.D. and Markus Rudin, Ph.D. |
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| Skill Level:
Intermediate |
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| Saturday, 18 April 2009 |
| 08:30 - 17:30 |
|
| OVERVIEW |
|
This one day course is
designed to introduce attendees to aspects of
carcinogenesis and cancer physiology that are
addressable by imaging. Our scientist teachers will
cover tumor biology, imaging strategies to probe tumor
‘hallmarks’ eg: proliferation, metabolism, apoptosis,
angiogenesis, etc; and use of imaging tools to
demonstrate therapy efficacy. The overall goal of the
course is to familiarize attendees with state-of-the-art
tumor imaging using MRI techniques. |
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| EDUCATIONAL OBJECTIVES
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Upon completion of this
case based session, participants should be able to:
- Describe basic pathophysiology of cancer with
specific to processes that are imaginable;
- Explain the hallmarks and pathways of cancer and
how they can be measured non-invasively;
- Describe relationship between hypoxia, pH and
radiation;
- Compare roles that different imaging modalities
can play in the characterization of preclinical
cancer models; and
- Define how imaging biomarkers may impact the
development of cancer drugs.
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|
| Saturday, 18 April 2009 |
| |
|
|
| 08:30
|
Tumor Biology
|
Robert
J. Gillies, Ph.D. |
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Imaging General
Tumor Hallmarks |
|
| 08:55
|
Proliferation –
Imaging DNA, Protein, Membrane Synthesis |
Ross J.
Maxwell, Ph.D. |
| 09:40
|
Tumor Metabolism:
MRS Studies |
John R.
Griffiths, D.Phil. |
| 10:15 |
Break - Meet the
Teachers |
|
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|
|
| 10:35
|
Acidosis
|
Natarajan Raghunand, Ph.D. |
| 11:10
|
PET - FDG and FLT
|
Jeffrey
L. Evelhoch, Ph.D. |
| 11:45 |
Angiogenesis –
Activated Endothelium |
Michal
Neeman, Ph.D. |
| 12:20
|
Break - Meet the
Teachers |
|
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|
|
13:45 |
Apoptosis |
Kevin M. Brindle,
D.Phil. |
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Imaging Gene
Expression/ Tumor (Surface) Antigens |
|
|
14:20 |
Surface Receptors –
Her2/neu |
Dmitri
Artemov, Ph.D. |
| 14:55 |
Reporter Gene
Expression |
Assaf A.
Gilad, Ph.D. |
| 15:30 |
Break - Meet the
Teachers |
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Evaluation of Therapy/ Biomarker |
|
|
16:00 |
Therapy
Evaluation in Preclinical Models |
Martin O. Leach, Ph.D. |
|
16:35 |
Techniques of Biomedical Imaging in Drug Discovery
and Development |
Nicholas van Bruggen,
Ph.D. |
| 17:10 |
Adjournment - Meet the Teachers |
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