Weekend Educational Course:
MR Physics for Physicists
Organizers: Michael H. Buonocore, M.D., Ph.D., Michael Markl, Ph.D. and Lawrence L. Wald, M.D., Ph.D.
 
Skill Level: Intermediate Advanced
 
Saturday, 18 April 2009
08:30 - 18:00

OVERVIEW
This one day course will explore the physical methods and mathematical models that underlie nearly all research and development in MRI and MR spectroscopy. Lectures will cover the general topics of spin physics, signal detection, generation of contrast, and imaging physics.
 
Specific topics include:
  • Quantum mechanical and semi-classical equations for describing spin dynamics;
  • The density matrix formalism and its applications in MRS;
  • Physical mechanisms of hyper polarization;
  • Radiofrequency field equations and reciprocity laws for signal detection;
  • Sources of noise and limits to SNR;
  • Tissue microstructure and molecular factors that govern image contrast;
  • Physical mechanism of exogenous and endogenous contrast agents;
  • Methods and models to describe magnetization exchange;
  • Physics and mathematics for susceptibility weighted imaging;
  • Mathematical description of dynamic equilibrium in fast sequences;
  • Calculation of effective relaxation times in fast sequences;
  • Applications of advanced electromagnetic theory in imaging;
  • Use of magnetization phase in applications;
  • Methods for quantitative parameter mapping, and;
  • Mathematical formalisms for RF pulse design.
 
EDUCATIONAL OBJECTIVES     
Upon completion of this course, participants should be able to:
  • Describe and derive equations for spin and magnetization dynamics, and list their main applications;
  • List physical mechanisms of spin relaxation and polarization;
  • Explain tissue microstructure responsible for relaxation differences;
  • Describe mathematical models used for understanding image contrast generation and parameter mapping; and
  • Describe mathematical models used for RF pulse design.
 

Saturday, 18 April 2009
     
  SPIN PHYSICS  
08:30 Quantum Mechanical and Semi-Classical Equations for Spin Dynamics Valerij G. Kiselev, Ph.D.
09:00  The Density Matrix Formalism and its Applications in MRS Thomas Ernst, Ph.D.
09:30 Physical Mechanisms for Hyperpolarization J.H. Ardenkjaier-Larsen, Ph.D.
     
  SIGNAL DETECTION  
10:00 Theory of RF Reciprocity Greig C. Scott, Ph.D.
10:30 Break - Meet the Teachers  
10:50 Sources of Noise and Limits of SNR Klaas Pruessmann, Ph.D.
     
  GENERATION OF CONTRAST  
11:20 Tissue Microstructure and Molecular Factors that Govern MRI Contrast Christopher C. Quarles, Ph.D.
11:50 Physical Mechanisms of Contrast Agents Peter M. Jakob, Ph.D.
12:20 Break - Meet the Teachers  
     
13:40 Physical Models for Magnetization Exchange (Magnetization Transfer) Vasily L. Yarnykh, Ph.D.
14:10 Physics and Mathematics Challenges in Susceptibility Weighted Imaging Jurgen R. Reichenbach, Ph.D.
     
  IMAGING PHYSICS  
14:40 Mathematical Description for Dynamic Equilibrium in Fast Sequences Oliver Bieri, Ph.D.
15:10 Calculation of Effective Relaxation Times and Weighting in Fast Sequences Matthias Weigel, Ph.D.
15:40 Break - Meet the Teachers  
     
16:00 Applications of Advanced Electromagnetic Theory Richard W. Bowtell, Ph.D.
16:30 Use of Magnetization Phase in Applications Oliver Wieben, Ph.D.
17:00 Methods for Quantitative Relaxation Parameter Mapping Paul S. Tofts, Ph.D.
17:30 Mathematical Formalisms for RF Pulse Design Adam B. Kerr, Ph.D.
18:00 Adjournment - Meet the Teachers