Room 155 EF

10:30 - 12:30

Moderators:

Bobby Kalb, Dow-Mu Koh

Mihaela Rata¹, Nina Tunariu^1,2, Dow M. Koh¹, Johann S. de Bono², Martin O. Leach¹, David John Collins¹, and Matthew D. Blackledge^1
1CR-UK and EPSRC Cancer Imaging Centre, Institute of Cancer Research/ Royal Marsden Hospital, Sutton, Surrey, United Kingdom, ²Drug Development Unit, Institute of Cancer Research/ Royal Marsden Hospital, Sutton, Surrey, United Kingdom

Inter and intra-tumour heterogeneity in patients with metastatic disease poses an important challenge to anticancer therapy. A multi-parametric whole body (WB) MRI approach may combine excellent anatomic resolution with functional techniques. Our goals were: a) investigate a new methodology to assess WB tumour heterogeneity; b) validate this hypothesis on a paired pre/post treatment data. The new methodology successfully demonstrated pre and post-treatment tumour heterogeneity for two patients with different cancers. Such analysis allows observation of changes in the mean ADC and NE values after treatment for each tissue class independently and provides additional functional tumour response characterisation compared to using each method alone.

Himanshu Bhat¹, Juan Cevasco², Daniel Cornfeld³, Ralph Strecker⁴, Bruce S. Spottiswoode⁵, Frank H. Miller⁶, Charles Fasanati⁶, Stephen F. Cauley⁷, Kawin Setsompop⁷, and Keith A. Heberlein^8
1Siemens Medical Solutions, Charlestown, MA, United States, ²Centro de Diagnósticos Brasil (CDB), Sao Paulo, Brazil, ³Department of Diagnostic Radiology, Yale-New Haven Hospital, New Haven, CT, United States, ⁴Siemens Healthcare, Sao Paulo, Brazil, ⁵Siemens Medical Solutions USA Inc., Chicago, IL, United States, ⁶Department of Radiology, Northwestern University Feinberg School of Medicine, Chicago, IL, United States, ⁷A. A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, MA, United States, ⁸Siemens Healthcare USA, Charlestown, MA, United States

This study shows feasibility of using the blipped CAIPIRINHA technique with a slice acceleration factor of 2 for DWI in the liver. Comparable quantitative and qualitative results can be acquired with this technique in half the scan time compared with a conventional non slice accelerated sequence.

K Downey¹, M. Jafar¹, S Hazell², A D. Attygalle², Veronica A. Morgan¹, M Schmidt¹, T. E. Ind³, D. P. Barton³, J. H. Shepherd³, and Nandita M. deSouza^1
1Magnetic Resonance Imaging, Institute of Cancer Research, Surrey, United Kingdom, ²Histopathology, The Royal Marsden Hospital, London, United Kingdom, ³Gynecological Surgery, The Royal Marsden Hospital, London, United Kingdom

Presentation of cervix carcinoma is often with small volume disease offering potential for fertility-sparing trachelectomy. Accurate preoperative depiction of tumor margins is crucial. The use of an endovaginal receiver coil has previously shown improvement in the detection of small tumors. At 3T EPI-DWI suffers disabling artefact and distortion with endovaginal coils. An alternative is Zoom-EPI (reduces distortion and improves resolution by reducing FOV). Purpose of study: Determine the sensitivity/specificity of T2-W + Zoom-DW imaging using an endovaginal coil at 3T for detecting cervical cancer, compare tumor:stromal contrast (T2-W vs. DWI) and document impact of the technique on surgical management.

Ronald Borra¹, Shanaugh McDermott², Onofrio Catalano³, Ciprian Catana⁴, Bruce R. Rosen¹, and Alexander R. Guimaraes^1,2
1Radiology; Massachusetts General Hospital, Martinos Center for Biomedical Imaging, Charlestown, MA, United States, ²Radiology, Massachusetts General Hospital; Division of Abdominal Imaging and Interventional Radiology, Boston, MA, United States, ³Radioloy, Naples General Hospital, Naples, Naples, Italy, ⁴Radiology; Massachusetts General Hospital, Massachusetts General Hospital, Charlestown, MA, United States

This study uses simultaneous PET-MRI acquisition to compare in patients with cancer FDG SUV to DWI ADC.

Keyanoosh Hosseinzadeh¹, Amir A. Borhani¹, Sushil Beriwal², and Peyman Kabolizadeh^2
1Radiology, University of Pittsburgh Medical Center, Pittsburgh, PA, United States, ²Radiation Oncology, University of Pittsburgh Medical Center, Pittsburgh, PA, United States

Purpose: evaluate the utility of gadexotate-enhanced MRI for detecting HCC in patient with liver cirrhosis who have T1-weighted hyperintense lesions. Method: 31 nodules were evaluated. Diagnostic performance of dynamic vs. dynamic and HB phase, Cohen statistics for interobserver agreement, bootstrap resampling technique for comparing lesion size, and fisher exact test for correlation between HB phase and histology were performed. Conclusion: the addition of HB phase did not improve diagnostic performance; however, our data shows that nodules demonstrating both precontrast T1 hyperintensity and HB phase hypointensity are malignant and there is a statistically significant size difference between benign and malignant lesions.

Valentina Taviani¹, Diego Hernando², and Scott B. Reeder^1,3
1Radiology, University of Wisconsin, Madison, WI, United States, ²Radiology, University of Wisconsin-Madison, Madison, WI, United States, ³Medical Physics, University of Wisconsin, Madison, WI, United States

Apparent diffusion coefficient (ADC) measurements are confounded by the presence of fat. This has important clinical implications as many organs such as the breast, liver and bone marrow contain fat. We developed a single-voxel diffusion-weighted (DW) spectroscopic sequence that allows ADC measurements corrected for the confounding effect of fat. Phantom experiments and in vivo measurements in the spinal bone marrow, breast and liver were performed. ADCs were compared to corresponding values obtained from conventional DW echo-planar imaging (DW-EPI). The two techniques were in agreement when the fat content was low but DW-EPI substantially underestimated ADC for higher fat fractions.

Peter E. Thelwall^1,2, John Skamarauskas^1,2, Daniel Vidler^2,3, Michael Dunn^2,3, Fiona Oakley², and Michael P. Gamcsik^4
1Newcastle Magnetic Resonance Centre, Newcastle University, Newcastle upon Tyne, Tyne and Wear, United Kingdom, ²Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, Tyne and Wear, United Kingdom, ³Medical Toxicology Centre, Newcastle University, Newcastle upon Tyne, Tyne and Wear, United Kingdom, ⁴Joint Department of Biomedical Engineering, University of North Carolina, Raleigh, North Carolina, United States

Glutathione is an endogenous antioxidant that forms a component of cellular defences against oxidative stress. Oxidative stress plays a key role in the progression of liver disease. We postulated that in vivo measurements of glutathione synthesis rate and concentration could provide a non-invasive biomarker of hepatic oxidative stress defences sensitive to the progression of liver disease. We employed MR spectroscopy to measure the metabolic incorporation of infused ¹³C-labelled glycine into glutathione into acute and chronic models of liver oxidative stress. Concentration of labelled glutathione was higher in the acute model, and lower in chronic models, compared to controls.

Robin A. de Graaf¹, Peter R. Luijten², Dennis W. J. Klomp², and Vincent Oltman Boer^3
1Yale University, MRRC, New Haven, CT, United States, ²UMC Utrecht, Utrecht, Netherlands, ³University Medical Center Utrecht, Utrecht, Netherlands

Abundant water-lipid susceptibility boundaries in the human breast can cause severe magnetic field inhomogeneity, thereby preventing the quantification and characterization of lipid signals. Intramolecular zero-quantum-coherences (ZQCs) are intrinsically insensitive towards magnetic field inhomogeneity. A novel 2D ZQC method is presented for the unambiguous characterization of the human breast lipid profile. The combination of cardiac/respiratory triggering and post-acquisition navigator echo correction provides high-quality 2D NMR spectra. Despite the presence of severe magnetic field inhomogeneity, the ZQC-based lipid profile can be reliably determined even in the human breast at 7T and expressed as fractions poly and mono-unsaturated and saturated fatty acids.

Yong Chen¹, Gregory R. Lee¹, Katherine L. Wright², Mark A. Griswold^1,2, Nicole Seiberlich², and Vikas Gulani^1,2
1Department of Radiology, University Hospitals of Cleveland, Cleveland, OH, United States, ²Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH, United States

Fast and accurate measurement of T1 relaxation times over the entire abdomen is challenging due to the large volume to be covered and respiratory motion. Here we present a high resolution 3D abdominal T1 mapping technique using the Look-Locker method, a stack-of-spirals trajectory and through-time non-Cartesian GRAPPA acceleration. This proposed technique allows fast T1 mapping of the whole abdomen in one breath-hold without the need for B1 mapping or image registration.

Yong Chen¹, Gregory R. Lee¹, Katherine L. Wright², Mark A. Griswold^1,2, Nicole Seiberlich², and Vikas Gulani^1,2
1Department of Radiology, University Hospitals of Cleveland, Cleveland, OH, United States, ²Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH, United States

Quantitative DCE-MRI in the liver is challenging due to the needs for high spatiotemporal resolution coverage over a large moving volume, and good data fidelity for model fitting. In this work, we developed an ultra-fast 3D imaging technique using a combination of a stack-of-spirals trajectory and through-time non-Cartesian GRAPPA acceleration. This technique allows fast imaging of the whole liver at high spatial resolution during free breathing. A dual-input, single compartment model was applied and quantitative liver perfusion maps were obtained, with parameter values that are in good agreement with the literature.