FUNCTIONAL MAGNETIC RESONANCE IMAGING (fMRI)
The most widely distributed cognitive neuroimaging technique founded on the assumption that stimulated brain areas exhibit a change in BOLD-contrast from perturbations in neural computation  (i.e. pure insertion hypothesis). A typical sequence for the observation of fast changes in MR-image intensity is EPI, although in principle BOLD can be detected with any other MR-sequence (e.g. like FLASH MRI) sensitive to changes in T2*. An increasing development of the 20 year old technique is the investigation of resting state network activity and connectivity.
- ↑ Bandettini PA, Wong EC, Hinks RS, Tikofsky RS, Hyde JS Time Course EPI of Human Brain Function during Task Activation MRM Vol 25 pp390-397 (1992)
- ↑ Ogawa SJ, Tank DW, Menon R, Ellermann JM, Kim S-G, Merkle H, Ugurbil K Intrinsic signal changes accompanying sensory stimulation: Functional brain mapping with magnetic resonance imaging PNAS Vol 89 pp5951-5955 (1992)
- ↑ Kwong KK, Belliveau JW, Chesler DA, Goldberg IE, Weisskoff RM, Poncelet BP, Kennedy DN, Hoppel BE, Cohen MS, Turner R, Cheng HM, Brady TJ, Rosen BR Dynamic magnetic resonance imaging of human brain activity during primary sensory stimulation. PNAS Vol 89(12) pp5675-5679 (1992)