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Overview
Molecular and cellular imaging is a fast developing field involving different
imaging modalities such as PET/SPECT, optical imaging and MRI.
Although MRI
is currently not the only key player in this field, it provides (1) the highest
spatial resolution and (2) multiple contrast features within the same study
providing both anatomical and physiological detailed information. These superior
imaging characteristics in combination with the current efforts in
targeted/smart contrast agents, reporter genes, and cellular imaging should
foster further progress in the field,
Molecular
MRI requires a multidisciplinary approach; molecular biologists, MR physicists,
chemists, image processors and clinicians should intensively interact and
determine where the field is going. It is the goal of this workshop to expand
the attendance from exclusively MRI researchers to other researchers involved
with all aspects of molecular imaging. The workshop will therefore
(1)
especially focus on bringing together scientists and clinicians from different
disciplines to provide an exceptional opportunity to interact, and
(2) provide
education on other imaging modalities and illustrate what MRI could do better or
differently.
Contributions by MRSI specialists on the advantages of integrating current
molecular and cellular imaging with MRSI approaches will also be encouraged.
Consistent
with our past study group meeting, the workshop will feature invited
presentations by young scientists, providing a combination of established and
well-recognized experts with younger speakers who will have a unique opportunity
to present their work. In addition to invited scientific presentations, the
program will include educational and plenary lectures, presentations of
proffered papers, and poster sessions
Educational
Objectives
At the conclusion of the workshop, attendees should be able to:
• list the characteristics of specific imaging probes, biophysical properties,
body distribution, ways to chemically attach linkers and targeted groups;
• explain methods to internalize compounds in cells and in ti issues and
understand the potential impact of introducing foreign imaging markers into
cells;
• describe how reporter genes work and the potential impact of overexpressing
genes in cells. How can they report on cell function? How is expression of
the gene detected?;
• explain how Manganese can be used as an imaging agent and what are its
applications;
• describe how CEST contrast agents work and where they can be used;
• assess the current status of targeted MRI contrast agents and molecular
imaging in the clinic; and
• identify the limitations of MRI and evaluate what the competitive optical and
nuclear techniques can do better in certain areas.
Audience
Description
This workshop is designed not only for exclusively MRI researchers, but also for
other researchers involved with all facets of molecular imaging. We would like
to especially welcome all imagers (MRI, PET, SPECT, CT, optical, etc.) and
molecular biologists interested in animal and cell manipulations and chemists
interested in contrast development with the long-term goal of bridging the gap
between imagers and non-imagers. Meeting this goal is a crucial step in
translational research.
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