Overview

The 4th workshop of the ISMRM White Matter Study Group will address MRI-detectable changes in the aging brain pertaining both to successful aging and age-related pathological states, with particular emphasis on the cerebral white matter.  Age-related pathological conditions of the brain include a large group of diseases that pose challenges in terms of diagnosis and interpretation, and that are increasingly making use of MRI as a source of surrogate markers of disease progression.  Age-related pathologies discussed in this workshop will specifically include neurodegenerative and neuroinflammatory conditions impacting cognition and motor performance in the elderly.  This disease group encompasses Alzheimer's Disease, cerebrovascular diseases, and other pathologies that are severely disabling to older patients and of enormous socio-economic impact, given the shift in the population's age structure towards higher life expectancy.  The varied pathogenic mechanisms involved offer a unique framework to improve our understanding of how histopathological alterations determine physical MR properties.

The relevance of both conventional and advanced MR techniques, as well as image analysis will be emphasized in two special technology workshop sessions including case studies.  Poster sessions, including poster presentations over lunch, will be targeted to enhance the exposure and participation of younger scientists and students.