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PRELIMINARY PROGRAM |
Educational Objectives:
Upon completion of this workshop, participants should be able to:
- Describe and explain normal
brain development as seen by MR imaging;
- Apply and interpret MR
spectroscopy to probe metabolic changes in CWMD;
- Design an appropriate MR imaging
protocol to routinely detect CWMD;
- Apply advanced MR techniques to
differentiate CWMD;
- Recognize CWMD and interpret MR
images to provide a (differential) diagnosis;
- Select and evaluate techniques
to monitor evolutionand treatment of CWMD.
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| Wednesday, 11 September
2002 |
| NORMAL WHITE MATTER IN NEONATES, INFANTS AND
CHILDREN |
| 08.00-09.00 |
REGISTRATION |
| 09.00 |
Opening
and Welcome
Frederick Barkhof, M.D., Ph.D., , Amsterdam, The Netherlands |
| 09.00-09.30 |
From
unmyelinated to myelinated white matter
- structural changes
- functional changes
- triggers for myelination
Bernard Zalc, M.D., Ph.D., Hôpital de la Salpêtrière, Paris, France |
| 09.30-10.00 |
Biochemical
changes associated with myelination
- changes in composition of white matter
- myelin maturation
Marie T. Vanier, M.D., Ph.D., Laboratoire Fondation Gillet-Merieux, Centre
Hospitalier Lyon-Sud, Pierre Benite, France |
| 10.00-10.30 |
Overview
of conventional MRI in myelination
Charles A. Raybaud, M.D., Ph.D., Neuroradiologie, CHU Timone, Marseille,
France |
| 10.30-11.00 |
x------------------------------------------Break------------------------------------------x |
| 11.00-11.30 |
Diffusion
imaging and brain maturation
Volker Engelbrecht, M.D., Ph.D., Heinrich-Heine-University, Department of
Diagnostic Radiology, Dusseldorf, Germany |
| 11.30-12.00 |
Magnetization
transfer and brain maturation
Joseph C. McGowan, Ph.D., United States Naval Academy, Electrical Engineering,
Annapolis, Maryland, USA |
| 12.00-12.30 |
MRS and
brain maturation
- metabolites
- different regions
Petra Pouwels, Ph.D., VU Medical Centre, Department of Clinical Physics,
Amsterdam, The Netherlands |
| 12.30-14.00 |
x------------------------------------------Break------------------------------------------x |
| 14.00-14.30 |
fMRI and
brain maturation
Ernst Martin, M.D., University Children's Hospital, Neuroradiology &
Magnetic Resonance, Zürich, Switzerland |
| 14.30-15.00 |
New
developments in MR
Peter Van Zijl, Ph.D., Johns Hopkins University Medical School, Department of
Radiology, Baltimore, Maryland, USA |
| 15.00-15.30 |
x------------------------------------------Break------------------------------------------x |
| 15.30-17.00 |
Parallel
Workshops (tutorials) |
|
1. Basic principles of magnetization transfer
Joseph C. McGowan, Ph.D.,
United States Naval Academy, Electrical Engineering, Annapolis, Maryland, USA |
|
2. Basic principles of DWI
Peter Van Zijl, Ph.D., Johns
Hopkins University Medical School, Department of Radiology, Baltimore, Maryland, USA |
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3. Paradigms of fMRI in children
Ernst Martin, M.D.,
University Children's Hospital, Neuroradiology & Magnetic Resonance, Zürich,
Switzerland |
| Thursday,
12 September 2002 |
INFLAMMATORY WHITE MATTER
DISORDERS IN CHILDREN
|
| 09.00-09.30 |
ADEM/MS
Folker Hanefeld, M.D., Georg-August-Universität, Kinderklinik &
Poliklinik, Göttingen, Germany |
| 09.30-10.00 |
Encephalitis
- AIDS
- viruses
- parasites
Charles A. Raybaud, M.D., Ph.D., Neuroradiologie, CHU Timone, Marseille,
France |
| 10.00-10.20 |
Congenital
CMV
Marjo S. van der Knaap, M.D., Ph.D., VU Medical Centre, Department of Child
Neurology, Amsterdam, The Netherlands |
| 10.20-10.40 |
Vasculitis
Lishya Liauw, M.D., Leiden University Medical Center, Department of Radiology,
Leiden, The Netherlands |
| 10.40-11.00 |
x------------------------------------------Break------------------------------------------x |
| 11.00-11.30 |
Lesson
from MS research
David H. Miller, M.D., Institute of Neurology, NMR Research Unit, London,
England, UK |
| HYPOXIC-ISCHEMIC WHITE MATTER DAMAGE |
| 11.30-12.00 |
Concepts
of regional vulnerability in neonates
Jane E. McGowan, M.D., Johns Hopkins School of Medicine, Division of
Neonatology, Baltimore, Maryland, USA |
| 12.00-12.30 |
Early and
late MRI features of periventricular leukomalacia
Frederik Barkhof, M.D., Ph.D., VU Medical Centre, Amsterdam, The Netherlands |
| 12.30-13.00 |
Contribution
of MRS to the understanding of energy failure in the neonatal brain
Klaas Nicolay, Ph.D., Eindhoven University of Technology, Department of
Biomedical Engineering, Eindhoven, The Netherlands |
| 13.00-14.00 |
x------------------------------------------Break------------------------------------------x |
| 14.00-15.30 |
Proffered
papers (10 minute presentation + 5 minute discussion each):
|
| 15.30-16.00 |
x------------------------------------------Break------------------------------------------x |
| 16.00-17.15 |
Proffered
papers (10 minute presentation + 5 minute discussion each):
|
| Friday,
13 September 2002 |
| HEREDITARY CHILDHOOD LEUKOENCEPHALOPATHIES |
| 09.00-09.30 |
Different
types of pathology underlying leukoencephalopathies on MRI
Jean-Jacques Martin, M.D., Ph.D., Universitaire Instelling Antwerpen, Antwerp,
Belgium |
| 09.30-10.00 |
Biochemical changes
- specific -- associated with a particular basic defect
- general -- associated with particular type of tissue damage
Marie T.
Vanier, M.D., Ph.D., Laboratoire Fondation Gillet-Merieux, Centre Hospitalier Lyon-Sud,
Pierre Benite, France |
| 10.00-10.30 |
Role of
MRI in the diagnosis – pattern recognition
Jacob Valk, M.D., Ph.D., VU Medical Centre, Department of Radiology,
Amsterdam, The Netherlands |
| 10.30-11.00 |
x------------------------------------------Break------------------------------------------x |
| 11.00-11.30 |
MR in the
definition of new white matter disorders
Marjo S. van der Knaap, M.D., Ph.D., VU Medical Centre, Department of Child
Neurology, Amsterdam, The Netherlands |
| 11.30-12.00 |
Post
mortem MRI compared to histopathology
Patrick Van der Voorn, M.D., VU Medical Centre, Department of Pathology,
Amsterdam, The Netherlands |
| 12.00-12.30 |
MRS
monitoring of leukoencephalopathies
Douglas L. Arnold, M.D., Montreal Neurological Institute, Montreal, Quebec, Canada |
| 12.30-14.00 |
x------------------------------------------Break------------------------------------------x |
| Monitoring
of Advanced Treatment Strategies with MR Techniques |
| 14.00-14.30 |
Bone
marrow transplantation in X-linked adrenoleukodystrophy (MRI, MRS, DTI)
Ali Fatemi, M.D., Neurogenetics Research Center, Kennedy Krieger Institute,
Johns Hopkins Medical School, Baltimore, Maryland, USA |
| 14.30-15.00 |
Monitoring
of labeled transplanted oligodendrocytes in Pelizaeus Merzbacher disease
Jeff W. M. Bulte, Ph.D., Johns Hopkins University, Department of Radiology,
Baltimore, Maryland, USA |
| 15.00-15.30 |
x------------------------------------------Break------------------------------------------x |
| 15.30-17.00 |
Plenary
Workshop (Three presentations of 20 minutes each and a 30 minute plenary discussion) |
|
1. Diffusion imaging in childhood leukoencephalopathies
Volker Engelbrecht, M.D., Ph.D., Heinrich-Heine-University, Department of Diagnostic
Radiology, Dusseldorf, Germany |
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2. Magnetization transfer applications in leukoencephalopathies
Massimo Filippi, M.D., Scientific Institute HSR, Department of Neuroscience, Milan, Italy |
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3. MRS in diagnosis and monitoring of leukoencephalopathies
Petra Pouwels, Ph.D., VU Medical Centre, Department of Clinical Physics, Amsterdam, The
Netherlands |
| Posters (on display Wednesday and Thursday in the coffee
and lunch areas) |
| D.
Ben Bashat |
Study
of white matter maturation from birth through adulthood using high b value diffusion
weighted imaging |
| R.
Carper |
Increased
white matter and gray matter volumes in young children with autism |
| F.
Cowan |
White
matter disease in perinatal asphyxia in the term infant -- what is the pattern of outcome? |
| H.
D'Arceuil |
Diffusion
Tensor MRI of neonatal cerebral development after hypoxia-ischema |
| C.
Fonda |
1H-MRS in a case of mitochondrial
Neuro-Gastro-Intestinal Encephalomyopathy (MNGIE) |
| E.
Jurkiewicz |
A
case of extensive changes in CNS due to viral infections |
| E.
Jurkiewicz |
Can proton magnetic resonance
spectroscopy be of any value in detection of early brain changes in healty.......of
patients with x-linked adrenoleukodystrophy. Report of a familiar X-ALD case. |
| M.
Lequin |
Neuroimaging
of an uncommon cause of bacterial encephalitis in the neonatal period |
| T.
Loenneker-Lammers |
MT
compatible incubator for imaging pre- and term neonates |
| C.
Majoie |
Diffusion-weighted
and DTI in children with metabolic disorders |
| H. J.
Mentzel |
Pediatric
brain MRI in neurofibramatosis type 1 disorder |
| D.
Mul |
Bilateral
renal agenesis, cerebral angiodysplasia and esophageal atresia |
| B.
Ter Rahe |
DTI
in young infants with peroxismal disorders |
| R.
Vermeulen |
Diffusion-weighted
MRI in severe neonatal hypoxic: "The White Cerebrum" |
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