MR of Transgenic Mouse Models ("MR Omics")
E. Mark Henkelman, Ph.D., and Alan P. Koretsky, Ph.D., Organizers
Friday, 11 July 2003, 08:00 - 15:00

ast updated 05 May 2009

Course Description
The past twenty years have seen an explosion in our ability to manipulate the mouse genome to make an extraordinary variety of animal models to study physiopathology and disease.  In many cases simple changes in the mouse genome lead to complex changes in tissue function.  This complexity combined with the large number of interesting models being produced has led to a growing interest in efficient ways to phenotype and measure specific biological processes in the mouse.  Over the same time period there has been an explosion in the range of information that can be obtained by magnetic resonance (MR) techniques.  Due to the wide range of information available from MR and the large body of work applying MR to rodents, it has been a natural fit to apply MR to mouse models.  The purpose of this five-and-one-quarter hour course is to discuss the wide range of applications for the marriage of MR and mouse genomics and to illustrate the impact MR is having on understanding a wide variety of mouse models.

Educational Objectives:

The course will give an understanding of the following topics:
 Different ways in which molecular biologists are using mouse models to understand development and disease;
An overview of small animal imaging; applications of MR to mouse models of cancer, neurological and cardiac diseases;
How MR and mouse models are being used for drug discovery;
Different approaches being taken to get molecular information from small animal imaging techniques.
08:00 Mouse Models of Human Disease
Special guest lecture from outside the field.
Alexandra L. Joyner
08:45 Overview of Small Animal Imaging R. Mark Henkelman
09:30 MR of Mouse Models of Neurological Disorders Joseph A. Frank
10:15 Break
10:45 MR of Mouse Models of Cardiac Disease Robert G. Weiss
11:30 MR of Mouse Models of Cancer Robert J. Gillies
12:15 Break
13:30 MR of Mouse Models for Drug Discovery Nicholas van Bruggen
14:15 Molecular/Cellular Imaging of Small Animals Erik Shapiro
15:00 Adjournment