MR
of Transgenic Mouse Models ("MR Omics") E. Mark Henkelman, Ph.D., and
Alan P. Koretsky, Ph.D., Organizers
Friday, 11 July 2003, 08:00 - 15:00
Last
updated 05 May 2009
Course
Description The past twenty years have seen an explosion in our ability to manipulate the
mouse genome to make an extraordinary variety of animal models to study physiopathology
and disease. In many cases simple changes in the mouse genome lead to complex
changes in tissue function. This complexity combined with the large number of
interesting models being produced has led to a growing interest in efficient ways to
phenotype and measure specific biological processes in the mouse. Over the same time
period there has been an explosion in the range of information that can be obtained by
magnetic resonance (MR) techniques. Due to the wide range of information available
from MR and the large body of work applying MR to rodents, it has been a natural fit to
apply MR to mouse models. The purpose of this five-and-one-quarter hour course is to
discuss the wide range of applications for the marriage of MR and mouse genomics and to
illustrate the impact MR is having on understanding a wide variety of mouse models.
Educational
Objectives:
The course will give an
understanding of the following topics: Different ways in which molecular biologists are
using mouse models to understand development and disease; An overview of small animal imaging; applications of MR
to mouse models of cancer, neurological and cardiac diseases; How MR and mouse models are being used for drug
discovery; Different approaches being taken to get molecular
information from small animal imaging techniques.
08:00
Mouse Models of Human Disease Special guest lecture from outside the field.
Different ways in which molecular biologists are
using mouse models to understand development and disease;