Basics of Brain Function - Day 1
Peter Jezzard, Ph.D., Douglas C. Noll, Ph.D., and Steve C.R. Williams, Ph.D., Organizers
Thursday, 10 July 2003, 09:00 - 17:50

Last updated 05 May 2009

Course Description
This eleven-and-three-quarter hour course will provide an introduction to all aspects of MRI of human brain function.  The course starts with an overview of regional functional specialization of the brain, and the way in which cortical areas inter-communicate.  This is followed by a discussion of the metabolic and hemodynamic response of the brain to activation.  The pulse sequences used to map brain function are then introduced, along with an overview of the artifacts that should be anticipated.   The second day of the course details the principles of fMR paradigm design, and introduces the statistical methods used to analyze the data.  After describing emerging (non BOLD) methods for assessing brain function/communication, the course concludes with a series of talks providing examples of fMRI applications.

Educational Objectives:

Upon completion of this course, participants should be able to
Identify the principle areas of the brain used in sensory perception, motor activity, language, and cognition;
Describe the way in which these cortical areas inter-communicate, both at the electrical and chemical level;
Describe the associated hemodynamic responses of the brain that accompany electrical and metabolic activity;
Define and compare the various MRI pulse sequences that can be used to map human brain function;
Identify the sources of artifacts that are inherent in many fMRI procedures and describe methods to minimize these artifacts;
Design a simple fMRI paradigm, and describe the principles used in data analysis;
Explain the principles of perfusion-based fMRI and the methods used to construct maps of white matter tracts;
Identify the areas of application of fMRI in neurology, psychiatry and basic neuroscience
09:00 Introduction Course Chairs
Session I: Functional Anatomy and Connectivity
09:10 Grey Matter Functional Specialization Arno Villringer
09:45 Introduction to Neuronal Anatomy and Electrical Activity Mark S. Cohen
10:25 Break
Session II: Neurochemistry and Metabolic Response
10:45 Neurochemistry and Neurotransmitter Systems Kelvin O. Lim
11:20 Neuronal Metabolism Graeme F. Mason
11:55 Hemodynamic Responses to Neuronal Activity Arno Villringer
12:30 Break
Session III: The BOLD Signal
14:00 Sources of BOLD Signal/Field Strength Issues Charles S. Springer
14:35 Temporal BOLD Characteristics and Non-Linearity Douglas C. Noll
15:10 Spatial Resolution Limits Ravi S. Menon
15:45 Break
Session IV: fMRI Pulse Sequences and Artifacts
16:05 BOLD fMRI Sequences Peter Jezzard
16:40 Susceptibility Artifacts Lawrence L. Wald
17:15 Physiological Noise in fMRI and Strategies for Correction Gunnar Kruger
17:50 Adjournment