fMRI Experimental Methods
R. Todd Constable, Ph.D., and Mathias Hoehn, Ph.D., Organizers

Last updated 05 May 2009

Course Description:
This four-hour course will provide a comprehensive overview of the latest findings with respect to technical aspects of fMRI.  Topics covered will include the relationship of the MR signal change to the underlying brain activity, experimental design considerations, acquisition and analysis methodology.  The course attendee will be able to design, run, analyze, and interpret a state-of-the-art fMRI study following this course.

Educational Objectives:
Upon completion of this session, participants should be able to:

Explain the latest developments in fMRI with respect to understanding the underlying physiology leading to the BOLD response and its relationship to neuronal activity, and the influence of pharmacological substances on activation;
Describe the factors influencing paradigm design and the optimum acquisition strategy for event-related versus block designs;
Recognize which analysis approach is most appropriate for a particular experimental design;
Describe the spatial limits of fMRI and factors influencing resolution.

Sunday, 13 July

Physiological Changes

07:00 Mechanisms of fMRI Richard B. Buxton
07:30 fMRI in Birds Annemie van der Linden

Monday, 14 July

Experimental Design (Paradigms/Acquisition Strategies)

07:00 Paradigm Design Issues: Event-related vs. Block Design Rasmus M. Birn
07:30 Acquisition Strategies/Pulse Sequences Xiaoping P. Hu

Tuesday, 15 July

Data Analysis

07:00 Model-Driven Analysis Keith J. Worlsey
07:30 Exploratory Data Analysis James J. Pekar

Wednesday, 16 July

Spatial Temporal Resolution Limitations

07:00 Pharmacological Modulations of fMRI Mathias Hoehn
07:30 Spatial Resolution Issues R. Todd Constable