Spectroscopy Beyond NAA
Peter S. Allen, Ph.D., John R. Griffiths, M.B.B.S., D.Phil., Rolf Gruetter, Ph.D., and Stephen R. Williams, D.Phil., Organizers

Last updated 05 May 2009

Course Description:
This four-hour course will cover the following subjects:
Day 1: Introduction, including biological relevance and an overview of techniques.
Day 2: Methods for data processing to extract quantitative information.
Day 3: Applications at 1.5 Tesla of 1H and 13C and use of 15N to follow metabolite fluxes.
Day 4: Specialized methods and applications in the use of 13C at high field.

Educational Objectives:
Upon completion of this session, participants should be able to:

List the major metabolites in addition to NAA, Crn, Cho that can be detected in vivo in the brain by MRS;
Describe the biological and clinical importance of these metabolites;
List the key factors to achieve good spectra;
Describe the principles of data analysis in both frequency and time domain;
Explain how MRS can be used to measure metabolic fluxes as well as steady state concentrations;
List the advantages and disadvantages of 13C/15N with respect to 1H.

Sunday, 13 July

07:00 Introduction Stephen R. Williams
07:30 Glucose, Glycogen, Glutahtione and GABA by 1H and 13C NMR Rolf Gruetter

Monday, 14 July

07:00 Time-Domain Based Analysis Danielle Graveron-Demilly
07:30 LCModel Applications at High Field Ivan Tkac

Tuesday, 15 July

07:00 1H MRS at 1.5/2 T Petra Pouwels
07:30 Potential and Promise for 15N NMR Keiko Kanamori
07:45 13C MRS at 1.5 T Stefan Bluml

Wednesday, 16 July

07:00 13C NMR: Past and Present Peter G. Morris
07:30 Indirect Detection of 13C Label/Editing at 3 T Vincent P. Lebon