Peter S. Allen, Ph.D., John R.
Griffiths, M.B.B.S., D.Phil., Rolf Gruetter, Ph.D., and Stephen R. Williams, D.Phil.,
updated 05 May 2009
Course Description: This four-hour course will cover the following subjects:
Day 1: Introduction, including biological relevance and an overview of techniques.
Day 2: Methods for data processing to extract quantitative information.
Day 3: Applications at 1.5 Tesla of 1H and 13C and use of 15N
to follow metabolite fluxes.
Day 4: Specialized methods and applications in the use of 13C at high field.
Educational Objectives: Upon completion of this session, participants should be able to:
major metabolites in addition to NAA, Crn, Cho that can be detected in vivo in
the brain by MRS; Describe the biological and
clinical importance of these metabolites; List the key factors to achieve
good spectra; Describe the principles of data
analysis in both frequency and time domain; Explain how MRS can be used to
measure metabolic fluxes as well as steady state concentrations; List the advantages and
disadvantages of 13C/15N with respect to 1H.
Sunday, 13 July
Stephen R. Williams
Glutahtione and GABA by 1H
and 13C NMR