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MR of Transgenic Mouse Models (MR Omics)
Daniel H. Turnbull, Ph.D., Organizer
Sunday, 16 May 2004, 08:00 - 16:30

ast updated 05 May 2009

Course Description
The past twenty years have seen an explosion in our ability to manipulate the mouse genome to make an extraordinary variety of animal models to study physiopathology and disease.  In many cases simple changes in the mouse genome lead to complex changes in tissue function.  This complexity combined with the large number of interesting models being produced has led to a growing interest in efficient ways to phenotype and measure specific biological processes in the mouse.  Over the same time period there has been an explosion in the range of information that can be obtained by magnetic resonance (MR) techniques.  Due to the wide range of information available from MR and the large body of work applying MR to rodents, it has been a natural fit to apply MR to mouse models.  The purpose of this course is to discuss the wide range of applications for the marriage of MR and mouse genomics and to illustrate the impact MR is having on understanding a wide variety of mouse models.
Audience Description:
MR of Transgenic Mouse Models is designed to impact investigators and students from almost all areas and thus it is anticipated that this course will attract a diverse audience.  The course is designed for people who are interested in modeling human disease with mouse models; assessing mouse models of human disease with MR; using mouse models to aid development of novel MR techniques to assess tissue structure and function; molecular imaging; drug development; multi-modality imaging of the mouse; molecular genetics of the mouse.
Educational Objectives:
The course will give an understanding of the following topics:
 Different ways in which molecular biologists are using mouse models to understand development and disease;
Small animal imaging
Applications of MR to mouse models of cancer, neurological and cardiac diseases;
Use of MR and mouse models for drug discovery; different approaches being taken to obtain functional and molecular information from mouse imaging techniques.


08:00 Mouse Models of Human Disease Alexandra L. Joyner
08:45 Overview of Mouse Imaging Methods R. Mark Henkelman
09:30 Break
10:00 MR of Mouse Models of Neurological Disease Daniel H. Turnbull
10:45 MR of Mouse Models of Cancer Zaver M. Bhujwalla
11:30 Break
13:00 MR of Mouse Models of Cardiac Disease Axel Haase
13:45 MR of Mouse Models for Drug Discovery Nicolau Beckmann
14:30 Break  
15:00 Functional MR Imaging and Spectroscopy in Mice Mathias Hoehn
15:45 Cellular/Molecular MR Imaging in Mice Jeff W.M. Bulte
16:30 Adjournment