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Spectroscopy: The Brain and Beyond
Peter S. Allen, Ph.D., John R. Griffiths, M.B.B.S., D.Phil., and Rolf Gruetter, Ph.D., Organizers

Last updated 05 May 2009

Course Description
Day 1: Introduction, covering technical issues related to metabolite quantification from in-vivo spectroscopy.  Day 2: The application of spectroscopy to the diagnosis and management of cancer patients, e.g., prostate and brain.  Day 3: Methods of spectral enhancement giving rise to superior quantification through water signal control and macromolecular background accommodation.  Day 4: Techniques and application of spectroscopy in the measurement of glycogen and lipids in skeletal muscle.
Audience Description:
This course is designed for MR Physics graduate students and above, and clinicians interested in non-invasive biochemical analysis.  Most will have had some practical experience of MRS.  It will be suitable for basic and clinical scientists with an interest in metabolism.

Educational Objectives:
Upon completion of this session, participants should be able to:

Describe the principles of spectral analysis through LC modeling;
Outline the mechanisms for intra-sequence signal loss when target metabolites have coupled spins;
List the key metabolites facilitating the spectroscopic recognition of tumor development in the prostate and the brain;
Outline how water can be used as an internal concentration standard with minimal associated spectral artifacts;
Explain how macromolecular contamination of spectra can be recognized and mitigated;
Explain how MRS can be used to reflect metabolic processes in muscle using glycogen or lipids.


Tuesday, 18 May
07:00 The LC Modeling Approach Pierre-Gilles Henry
07:20 Discussion
07:30 Coupled-Spin-Metabolite Signal Yield Peter S. Allen
07:50 Discussion
Wednesday, 19 May
07:00 MRS in Cancer of the Prostate Daniel Vigneron
07:20 Discussion
07:30 MRS and Brain Cancer Martin O. Leach
07:50 Discussion
Thursday, 20 May
07:00 Using Water as an Internal Standard Wolfgang Dreher
07:20 Discussion
07:30 Dealing with Macromolecular Signals Douglas L. Rothman
07:50 Discussion
Friday, 21 May
07:00 In Vivo Measurement of Muscle and Liver Glycogen Peter G. Morris
07:20 Discussion
07:30 Myo-cellular Lipid Measurements Chris Boesch
07:50 Discussion