Measuring Vascular Function in Cancer

Room 618 - 620 16:00 - 18:00 Chairs: David L. Buckley and Jeffrey L. Evelhoch


Prog #

16:00 382.

Use of a High Temporal Resolution Population-Averaged Arterial Input Function to Improve DCE-MRI Reproducibility in

Phase I Clinical Trial Settings

Geoff James Martin Parker1, Caleb Roberts1, Andrew Macdonald1, Sue Cheung1, Giovanni A, Buonaccorsi1,

David L. Buckley1, Alan Jackson1, Yvonne Watson1, Karen Davies1, Gordon C. Jayson2

1University of Manchester, Manchester, UK; 2Christie Hospital, Manchester, UK
16:12 383.

Blood Plasma Gd-DTPA Concentration Derived from Skeletal Muscle is Comparable with a Direct Measurement from the


Simon Walker-Samuel1, Benjamin R. Knowles1, James A. d'Arcy1, Neil J. Smith2, Chris Parker3, Gina Brown3,

Martin O. Leach1, David J. Collins1

1Institute of Cancer Research, Sutton, Surrey, UK; 2Mayday University Hospital, Thornton Heath, Surrey, UK; 3Royal Marsden and NHS Foundation Trust, Sutton, Surrey, UK
16:24 384.

Tumor Arterial Input Function (AIF) Estimation in DCE-MRI Studies Using a Multiple Reference Tissue Method

Cheng Yang1, Walter M. Stadler1, Milica Medved1, Gregory S. Karczmar1

1University of Chicago, Chicago, Illinois, USA
16:36 385.

T1 Measurement of Flowing Blood and Arterial Input Function Determination for Quantitative 3D T1 –weighted DCE-MRI

Hai-Ling Margaret Cheng1, 2

1The University of Toronto, Toronto, Ontario, Canada; 2The Hospital for Sick Children, Toronto, Ontario, Canada
16:48 386.

Towards the Absolute Quantitation of DCE-MRI Pharmacokinetic Parameters:  Addressing the Assumption of Constant

Contrast Reagent Relaxivity and Its Effect on Ktrans

Greg Metzger1, 2, David Thomasson3, Marcelino Bernardo4, 5, Peter Choyke5

1Philips Medical Systems, Bethesda, Maryland, USA; 2University of Minnesota, Minneapolis, Minnesota, USA; 3Clinical Center, Bethesda, Maryland, USA; 4SAIC, Frederick, Maryland, USA; 5National Cancer Institute, Bethesda, Maryland, USA
17:00 387.

Quantification of Proton Exchange by Histological Verification of Fractional Blood Volume Determined by an Intravascular

T1 Contrast Agent at Prostate Tissue and Prostate Tumor

Lutz Lüdemann1, Ole Gemeinhardt1, Guido Correia Carreira1, Hagen Rehbein1, Carsten Warmuth1, Matthias Taupitz1, Dirk


1Charité, Berlin, Germany
17:12 388.

Simultaneous Determination of Perfusion and Microvascular Permeability: Measurement Precision with T1-Weighted DCE


Lucy Elizabeth Kershaw1, David L. Buckley1

1University of Manchester, Manchester, UK
17:24 389.

Effect of Transcytolemmal Water Exchange in DCE-MRI Data Analysis of Human Head and Neck Cancer

Sungheon Kim1, Harry Quon1, Laurie A. Loevner1, Mark Rosen1, Alex M. Kilger1, Jerry D. Glickson1, Harish Poptani1

1University of Pennsylvania, Philadelphia, Pennsylvania, USA
17:36 390.

Incorporating the Effects of Transcytolemmal Water Exchange in the Reference Region Model for DCE-MRI Analysis

Thomas Yankeelov1, Laura M. DeBusk1, P. Charles Lin1, John C. Gore1

1Vanderbilt University, Nashville, Tennessee, USA
17:48 391.

Error Propagation in Vessel Size Index Imaging

Emmanuel L. Barbier1, 2, Samuel Valable1, 2, Cédric Lucatelli1, 2, Irène Troprès, 23, Christoph Segebarth1, 2 Chantal Rémy1, 2

1U594, Grenoble, F-38043, France; 2Univ Grenoble 1, Grenoble, F-38043, France; 3IFR1, Grenoble, F-38043, France