Pre-Clinical Assessment of Vascular Function

Room 618 - 620         11:00 - 13:00                 Chairs: Natarajan Raghunand and Simon P. Robinson


Prog #

11:00 464.

Vascular Tortuosity is Culprit to Abnormal Perfusion in 9L Gliosarcoma Tumor

Moses Morakortoi Darpolor1, Robert C. Molthen2, Francisca C. Wu3, Kathleen M. Schmainda3

1Marquette University, Milwaukee, Wisconsin, USA; 2Dept. of Veterans Affair, Zablocki VAMC, Milwaukee, Wisconsin, USA; 3Medical College of Wisconsin, Milwaukee, Wisconsin, USA
11:12 465.

Assessment of Mouse Glioma Vasculature Using SPIO and Small Molecule Contrast Agents: Sequential Implementation of

Alternate Perfusion MRI Methodologies

Martin Mugar Pike1, Catherine P. Langford1, Cristine D. Neumann1, L Burt Nabors1, G Yancey Gillespie1

1University of Alabama at Birmingham, Birmingham, Alabama, USA
11:24 466.

The Role of VEGF in Growth of Brain Metastases from Single Cells as Visualized by Contrast Enhanced MRI

Kirsten Tracy1, Juan Juan Yin1, Jeeva Munasinghe1, Erik Shaprio1, Alan Koretsky1, Kathleen Kelly1

1National Institutes of Health, Bethesda, Maryland, USA
11:36 467.

The Role of Platelet-Derived Growth Factor on Tumour Vascular Function and Morphology In Vivo Assessed by

Susceptibility Magnetic Resonance Imaging

Simon P. Robinson1, Christian Ludwig2, Janna Paulsson3, John R. Griffiths1, Arne Ostman3

1St. George's, University of London, London, UK; 2University of Birmingham, Birmingham, UK; 3Karolinska Institute, Stockholm, Sweden
11:48 468.

Vascular Targeting Photodynamic Therapy (VTP): Correlations Between Hemodynamic and Photosensitized fMRI

Response Parameters in the Mouse Ear Tumor Model

Noa Madar1, Catherine Brami1, Vyacheslav Kalchenko1, Avigdor Scherz1, Michal Neeman1, Yoram Salomon1

1The Weizmann Institute of Sciences, Rehovot, Israel
12:00 469.

Assessment of Spin Echo BOLD FMR Imaging as a Prognostic Tool for Determining Chemotherapeutic Efficacy

Arup Bhattacharya1, Richard Mazurchuk1, Joseph A. Spernyak1, Shousong Cao1, Farukh A. Durrani1,

Youcef M. Rustum1

1Roswell Park Cancer Institute, Buffalo, New York, USA
12:12 470.

Characterizing Hypoxia-Induced Alterations in ECM Integrity of Solid Tumors In Vivo Using MRI and Fluorescent


Arvind P. Pathak1, Venu Raman1, Dmitri Artemov1, Zaver M. Bhujwalla1

1Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
12:24 471.

Molecular Imaging and Targeted Anti-Angiogenic Therapy in Cancer with Alphanubeta3-Targeted Nanoparticles

Patrick M. Winter1, Shelton D. Caruthers1, 2, Todd A. Williams1, John S. Allen1, Thomas D. Harris3,

Samuel A. Wickline1, Gregory M. Lanza1

1Washington University, St. Louis, Missouri, USA; 22Philips Medical Systems, Cleveland, Ohio, USA; 3Bristol-Myers Squibb Medical Imaging, Billerica, Massachusetts, USA
12:36 472.

Multi Parameter High-Resolution Magnetic Resonance Imaging and Spectroscopy of Tumors

Philipp Moerchel1, Gerd Melkus1, Volker Christian Behr1, Markus Kotas1, Peter Jakob1, Michael Flentje1

1University of Würzburg, Würzburg, Germany
12:48 473.

HRMAS 1H Spectroscopy of the Novel VEGF-RTK Inhibitor AG013736 in a Breast Cancer Model

Lisa J. Wilmes1, Samson Jarso1, Maria G. Pallavicini2, David R. Shalinsky3, John Kurhanewicz1, Nola M. Hylton1

1University of California San Francisco, San Francisco, California, USA; 2University of California Merced, Merced, California, USA; 3Pfizer Global Research and Development, La Jolla, California, USA