MRS of GABA, Glutamate and Glutathione: Detection Methods, Sensitivity Enhancement and Brain Mapping

Room 613 - 614         11:00 - 13:00                 Chairs: Ralph E. Hurd and Melissa J. Terpstra


Prog #

11:00 484.

Rapid Brain Glutamate Mapping in Central and Peripheral Gray Matter at 3 and 4 Tesla Using Short TE Proton-Echo

Planar-Spectroscopic Imaging (PEPSI)

Stefan Posse1, 2, Ricardo Otazo1, 3, Arvind Caprihan1, 4, Juan Bustillo2, Hongji Chen2, Chun Zuo5, Perry Renshaw5, Vincent

Magnotta6, Bryon Mueller7, Kelvin O. Lim7, Kamil Ugurbil7, Paul Mullins1, Charles Gasparovic1,

Jeffry R. Alger8

1The MIND Institute, Albuquerque, New Mexico, USA; 2University of New Mexico School of Medicine, Albuquerque, New Mexico, USA; 3University of New Mexico, Albuquerque, New Mexico, USA; 4New Mexico Resonance, Albuquerque, New Mexico, USA; 5Harvard University, Boston, Massachusetts, USA; 6University of Iowa, Iowa City, Iowa, USA; 7University of Minnesota, Minneapolis, Minnesota, USA; 8University of California in Los Angeles, Los Angeles, California, USA
11:12 485.

Glutamate Levels in Normal Appearing White and Gray Matter in Multiple Sclerosis Using TE-Averaged MRSI at 3T

Radhika Srinivasan1, Sarah Nelson1, Stephen Hauser1, Daniel Pelletier1

1University of California, San Francisco, California, USA
11:24 486.

Gender, Age and Regional Differences of Brain Glutamate Concentration in Healthy Subjects

Napapon Sailasuta1, Thomas Ernst1, Linda Chang1

1John A, Burns School of Medicine, University of Hawaii, Honolulu, Hawaii, USA
11:36 487.

Measurement of Heterogeneous Distribution of GABA in Gray and White Matters in the Human Brain Using Selective

Multiple Quantum Chemical Shift Imaging of GABA

In-Young Choi1, 2, Sang-Pil Lee1, 2, Hellmut Merkle3, Jun Shen3

1University of Kansas Medical Center, Kansas City, Kansas, USA; 2The Nathan Kline Institute, Orangeburg, New York, USA; 3NIH, Bethesda, Maryland, USA
11:48 488.

Evaluation of GABA Detection Sensitivity Gains Achieved with an 8-Channel Phased-Array Head Coil at 3.0 T in the Human

Dorsolateral Prefrontal Cortex Using the J-Editing Technique

Dikoma C. Shungu1, Xiangling Mao1, Lawrence S. Kegeles2

1Weill Medical College of Cornell University, New York, New York, USA; 2College of Physicians and Surgeons of Columbia University, New York, New York, USA
12:00 489.

Test-Retest Reliability of Dorsolateral Prefrontal Cortical GABA Measurement Using an 8-Channel Phased-Array Head Coil

with the J Editing Technique at 3T

Lawrence S. Kegeles1, Xiangling Mao2, Jonathan Dyke2, Robyn Gonzales1, Tacara N. Soones1, Dikoma C. Shungu, 12

1Columbia University, New York, New York, USA; 2Weill Medical College of Cornell University, New York, New York, USA

12:12 490.

Residual Water as a Navigator in GABA Editing Spectroscopy

Jan Willem W.C. van der Veen1, Jun Shen1

1NIH, NIMH, Bethesda, Maryland, USA

12:24 491.

In Vivo Evaluation of the Concentration of Macromolecule Species Involved in GABA Editing

Changho Choi1, Nicholas J. Coupland1, Paramjit P. Bhardwaj1, Nikolai Malykhin1, Dan Gheorghiu1, Peter S. Allen1

1University of Alberta, Edmonton, Alberta, Canada
12:36 492.

Simultaneous Detection of Unobstructed Glutamate and Glutamine Using Standard STEAM with Optimized Sequence

Parameters at 3, 4, 4.7, 7, and 9.4 Tesla - A Simulation Study

Shaolin Yang1, Jiani Hu2, Elliot A. Stein1, Yihong Yang1

1National Institute on Drug Abuse, NIH, Baltimore, Maryland, USA; 2Wayne State University, Detroit, Michigan, USA
12:48 493.

Double Edited NMR Spectroscoy for Detection of an Antioxidant Profile in the Human Brain In Vivo

Melissa Terpstra1, Rolf Gruetter1

1University of MN, Minneapolis, Minnesota, USA