Molecular Imaging in Atherosclerosis

Room 6E         16:30 - 18:30                 Chairs: Zahi A. Fayad and Patrick M. Winter


Prog #

16:30 554.

Multimodality Validation and Mechanistic Explanation of Functional Restoration of Murine Model of Myocardial Infarction

by Mouse Embryonic Stem Cells

Phillip C. Yang1, Shoko Ikeda1, Brett Fenster1, Stephen Hendry1, Sally Zhang1, Micha Drukker1, Irv Weissman1,

Philip Tsao1, Robert C. Robbins1

1Stanford University, Stanford, California, USA

16:42 555.

MRI Tracking of the Regional Persistence of Feridex-Labeled Mesenchymal Stem Cells in a Canine Myocardial Infarction


Ana Victoria Soto1, Wesley D. Gilson1, Dorota Kedziorek1, Adit Tal1, Danielle Crawford1, Parag Karmarker1,

Randell G. Young2, Mark F. Pittenger3, Jeff W. M. Bulte1, Dara L. Kraitchman1

1Johns Hopkins University, Baltimore, Maryland, USA; 2Osiris Therapeutics, Inc, Baltimore, Maryland, USA; 3Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
16:54 556.

Tracking of Intra-Coronary Delivered Mesenchymal Stem Cells Using MRI in a Porcine Model of Myocardial Infarction

John J. Graham1, Warren D. Foltz2, Yeusong Yang1, Jay S. Detsky3, Graham A. Wright1, 3, Alexander J. Dick1

1Sunnybrook and Women's College Health Sciences Centre, Toronto, ON, Canada; 2St Michael's Hospital, Toronto, ON, Canada; 3University of Toronto, Toronto, ON, Canada
17:06 557.

Relationship Between Macrophage Content and MRI Signal Intensity of Atherosclerosis Using Gadolinium-Containing

Immunomicelles Targeted to Macrophage Scavenger Receptor

Smbat Amirbekian1, Vardan Amirbekian2, Juan Gilberto S. Aguinaldo, Juan Carlos Frias, Venkatesh Mani,

Karen C. Briley-Saebo, Esad Vucic, Marc Sirol, Zahi Adel Fayad

1Emory University School of Medicine - Mount Sinai School of Medicine, New York, USA; 2Johns Hopkins University School of Medicine - Mount Sinai School of Medicine, New York, USA
17:18 558.

Method for Specific Detection of Plaque Angiogenesis in the Cholesterol-Fed Apolipoprotein-E Deficient Mouse with MR

Fluorine Spectroscopy of Integrin-Targeted Perfluorocarbon Nanoparticles at 11.7T

Emily A. Waters1, 2, John Stacy Allen2, Huiying Zhang2, Gregory M. Lanza2, Samuel A. Wickline, 12, Junjie Chen2

1Washington University in St. Louis, St. Louis, Missouri, USA; 2Washington University School of Medicine, St. Louis, Missouri, USA
17:30 559.

Imaging of Atherosclerosis In Vivo Using a Magnetic Resonance Contrast Probe Molecularly Targeted to Matrix

Metalloproteinases (MMPs)

Smbat Amirbekian1, Juan Gilberto S. Aguinaldo, Vardan Amirbekian2, Marc Sirol, Fabien Hyafil, Esad Vucic, Venkatesh Mani, Eric

Lancelot3, Claire

Corot3, Zahi Adel Fayad

1Emory University School of Medicine - Mount Sinai School of Medicine, New York, USA; 2Johns Hopkins University School of Medicine - Mount Sinai School of Medicine, New York, USA; 3Guerbet, Paris, France
17:42 560.

Visualizing the Uptake of Combidex (Ferumoxtran-10) in a Rat Model of AAA Using Positive and Negative Contrast


Joan M. Greve1, Eiketsu Sho2, Maureen Tedesco1, Masahiro Terashima1, Michael V. McConnell1, Ronald L. Dalman1, Maj Hedehus3,

Charles H. Cunningham1, Steven M. Conolly4, Charles A. Taylor1

1Stanford University, Stanford, California, USA; 2KAI Pharmaceuticals, Inc., South San Francisco, California, USA; 3Varian, Inc., Palo Alto, California, USA; 4University of California Berkeley, Berkeley, California, USA
17:54 561.

In Vivo MR Imaging of Bone Marrow Cell Trafficking to Atherosclerotic Plaques

Bensheng Qiu1, Fabao Gao1, Piotr Walczak1, Jiangyang Zhang1, Sourav Kar1, Jeff WM Bulte1, Xiaoming Yang1

1Johns Hopkins Univ School of Medicine, Baltimore, Maryland, USA
18:06 562.

Molecular Imaging of Angiogenic Therapy in Peripheral Vascular Disease with Alphanubeta3-Targeted Nanoparticles

Patrick M. Winter1, Shelton D. Caruthers1, 2, John S. Allen1, Todd A. Williams1, Thomas D. Harris3,

Samuel A. Wickline1, Gregory M. Lanza1

1Washington University, St. Louis, Missouri, USA; 2Philips Medical Systems, Cleveland, Ohio, USA; 3Bristol-Myers Squibb Medical Imaging, Billerica, Massachusetts, USA
18:18 563.

Positive Contrast MR Imaging of In Vivo Atherosclerosis in a Rabbit Model Using Ultrasmall Iron Oxide Particles

Karen C. Briley-Saebo1, Venkatesh Mani1, Fabien Hyafil1, Zahi A. Fayad1

1Mount Sinai School of Medicine, New York, New York, USA