CLINICAL SCIENCE FOCUS SESSION: Alzheimer's and Other Degenerative Diseases

Room 4C - 3,4         13:30 - 15:30                 Chairs: John D. Port and Nicola De Stefano


Prog #

13:30 719.

Greater Blood Flow Reduction in Mild Diffuse Lewy Body Disease Than in Mild Alzheimer's Disease

Tamara Fong1, Daniel Press1, David Charles Alsop1

1Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA
13:40 720.

Combining CASL with Uni- And Multi-Variate Methods for Early Detection of Alzheimer's Disease

Iris Asllani1, Christian Habeck1, Ajna Borogovac1, Yaakov Stern1, Truman Brown1

1Columbia University, New York, New York, USA
13:50 721.

Regional Degradation of White Matter Ultrastructure in Mild Cognitive Impairment and Alzheimer’s Disease by Diffusion

Tensor Imaging

Yu Zhang1, Norbert Schuff1, G-H Jahng1, Whitney Bayne1, Susumu Mori2, L Schad3, Susanne Mueller1, Joel Kramer, Kristine Yaffe

Hellen Chang Chui4, William J. Jagust5, Bruce L. Miller, Michael W. Weiner1

1VA Medical Center and UC San Francisco, San Francisco, California, USA; 2Johns Hopkins University, Baltimore, Maryland, USA; 3German Cancer Research Institute, Heidelberg, Germany; 4University of Southern California, Los Angeles, California, USA; 5Lawrence Berkeley National, Laboratory and UC Berkeley, Berkeley, California, USA
14:00 722.

Thin Slice Magnetic Resonance Histological Imaging and Co-Regisitration of Beta-Amyloid Plaques

Mark David Meadowcroft1, Shutong Zhang2, James R. Connor1, Michael B. Smith1, Qing X. Yang1

1Pennsylvania State University - College of Medicine, Hershey, Pennsylvania, USA; 2The University of Pennsylvania, Philadelphia, Pennsylvania, USA
14:10 723.

Alterations in Cerebral Microstructual Integrity in Normal Aging and in Alzheimer’s Disease: A Multi-Contrast Diffusion MRI


Hanzhang Lu1, Jens H. Jensen1, Cathy Hu1, Maria F. Falangola1, Anita Ramani1, Steven Ferris1, Joseph A. Helpern1

1New York University, New York, USA
14:20 724.

DTI Measures Predict the Performance on Cognitive Tests in Elderly and Patients with Early Alzheimer's Disease

Hongyan Ni1, Jianhui Zhong1, Voyko Kavcic2

1University of Rochester, Rochester, New York, USA; 2University of rochester, Rochester, New York, USA
14:30 725.

Towards an Early Prognosis of Alzheimer’s Disease: Probing the Diffusion Characteristics of the Entorhinal Cortex and

Perforant Pathway with Turboprop-DTI

Minzhi Gui1, Ana Solodkin2, James A. Mastrianni2, Konstantinos Arfanakis1

1Illinois Institute of Technology, Chicago, Illinois, USA; 2University of Chicago, Chicago, Illinois, USA
14:40 726.

Asymptomatic Members with SOD1 Mutation in a Large Kindred with Familial Amyotrophic Lateral Sclerosis Have

Abnormal Water Diffusion Characterisitcs

Man Cheuk Ng1, Jenny T. Ho2, S. L. Ho1, Raymond Lee2, Geng Li3, Y. Q. Song1, K. H. Chan1, T. S. Cheng1,

Edward S. Yang1, L. Y. Leong2

1The University of Hong Kong, Pokfulam, N/A, Hong Kong, People’s Republic of China; 2Queen Mary Hospital, N/A, Hong Kong, People’s Republic of China; 3The Jockey Club MRI Centre, The University of Hong Kong, Pokfulam, N/A, Hong Kong, People’s Republic of China
14:50 727.

Robust Assessment of Cortical Thinning in Brain MRI by Generalized Complexity Measures

Karl Young1, 2, Norbert Schuff1, 2

1University of California San Francisco, San Francisco, California, USA; 2Veterans Affairs Medical Center, San Francisco, California, USA
15:00 728.

Gray Matter Thinning Demonstrated in ALS Using Novel Thickness Maps

Don C. Bigler1, Kevin R. Scott1, Mark D. Meadowcroft1, Jianli X. Wang1, Helen E. Stephens1, Zachary Simmons1,

Qing X. Yang1, Michael B. Smith1

1Penn State College of Medicine, Hershey, Pennsylvania, USA
15:10 729.

Thalamic Involvement Following Mild Brain Injury: In Vivo Occult Pathology Demonstrated by Diffusion Kurtosis Imaging

Yulin Ge1, Hanzhang Lu1, Jens H. Jensen1, Joseph A. Helpern1, Joseph Reaume1, Robert I. Grossman1

1New York University School of Medicine, New York City, New York, USA
15:20 730.

Brain Morphometry in Methamphetamine Users in Relation to Cumulative Drug Exposure

Renat Yakupov1, Linda Chang1, Dan Alicata1, Darlene Ramones1, Christine Cloak1, Thomas Ernst1

1University of Hawaii, John A. Burns School of Medicine, Honolulu, Hawaii, USA