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Clinical DTI/PWI/fMRI
Alberto Bizzi, Soonmee Cha, Organizers

Each session of this four-hour course will focus on one topic: angiogenesis and permeability; white matter dysfunction; gray matter dysfunction; and cerebral hemodynamics. Current state of knowledge and topics of interest in clinical research fMRI, DT-MRI, tractography and perfusion MRI (bolus tracking and arterial spin labeling) will be illustrated in the context of depicting underlying pathophysiology of neoangiogenesis, axonal injury, demyelination and ischemia. Emphasis will be on how to perform studies in the clinical environment with the cooperation of patients. Limitations and Quality Assurance (QA) procedure will be described.

Educational Objectives:
Upon completion of this session, participants should be able to:

Describe the main applications and contributions of fMRI, DTI and tractography and bolus tracking and arterial spin labeling perfusion MR imaging in clinical neuroscience;
Describe the technical requirements necessary to implement robust, accurate and repeatable clinical advanced MR studies in patients with neurological diseases;
List the potential contribution of PWI, DTI and fMRI to formulate diagnosis, prognosis and evaluate different therapeutic strategies in the neurological diseases focus of this course;
  • Discuss the basic MR principles involved in the quantification of angiogenesis and permeability using perfusion MR imaging;
  • Implement new quantitative MR methods that may quantify cumulative brain damage that better correlate with the disability score;
Recognize challenges, limitations and pitfalls of performing advanced MR studies to answer clinical questions in neurological patients; and
  • Implement Quality Assurance (QA) procedures necessary to run a reliable and successful advanced MRI clinic.
Audience Description:
This course is designed for students in EE/BME/Physics/Medicine who are interested in learning when and how advanced MRI techniques may answer clinical questions; neuroscientists/engineers who are working with advanced MRI methods and are interested in learning which are the relevant clinical questions to address with fMRI/DTI/PWI in neuroscience; physicians/neuroscientists who are interested in learning about achievements and limitations of using advanced MRI techniques to answer clinical questions in neuroscience; and physicians/neuroscientists/engineers who are planning to perform state-of-the-art advanced MRI studies in their clinical practice.


Tuesday, 9 May
Angiogenesis and Permeability: Perfusion MRI
07:00 What Can Quantitative DCE T1-Weighted MR Imaging Tell Us? Paul S. Tofts, D.Phil.
07:30 Grading, Therapy Monitoring, and Predicting Outcome of Glioma Soonmee Cha, M.D.
Wednesday, 10 May
Measuring Extent of White Matter Disease: Diffusion MRI
07:00 Diffusion Tensor Imaging of Traumatic Brain Injury Pratik Mukherjee, M.D., Ph.D.
07:30 Clinical Output of DTI Measurements in Multiple Sclerosis Olga Ciccarelli, Ph.D.
Thursday, 11 May
Brain Function and Cortical Reorganization: Functional MRI
07:00 Functional Connectivity Mark J. Lowe, Ph.D.
07:30 Combining fMRI and DTI Applications Andrei I. Holodny, M.D.
Friday, 12 May
Advanced Imaging of the Pediatric Brain
Diffusion MRI in the Fetus and Newborn
Andrea Righini, M.D.
07:30 Measuring Brain Perfusion in the Pediatric Brain Michela Tosetti, Ph.D.