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Molecular Imaging
Markus Rudin, Klaas Nicolay, Organizers

Saturday, 6 May 2006, 11:00 - 13:00
Last updated 19 February 2009

The first part of this one-day course will focus on technological aspects of molecular imaging. The physical principles and technical issues associated with each of the imaging modalities will be explained. The comparison of the strengths and weaknesses should reveal the complementarity of the various techniques and illustrate the importance of fusion approaches. Probe design will be discussed in two contributions: The first part deals with the physical principle of the reporter systems, while the second contribution describes issues encountered in probe design: sensitivity, specificity, bioavailability, safety, and translatability to the clinics. Various molecular imaging applications (studies of gene expression, protein function, cell migration) will be discussed in the third part.
Educational Objectives:
Upon completion of this session, participants should be able to:
• Explain basic concepts and the potential of molecular imaging as a basic research tool, for diagnostics and for monitoring therapeutic interventions: role of molecular versus structural and physiological readouts;
• Recognize relevance of multi-modality imaging strategy (MRI might not be the optimal method to tackle a specific problem): select optimal imaging strategy for a specific problem;
• Explain ‘contrast’ principles of the various reporter moieties (paramagnetic &, superparamagnetic compounds, fluorescent dyes and proteins, positron emitters, gamma ray emitters): recognize strengths and weaknesses of each reporter; and
• Evaluate molecular probe concepts (e.g. direct versus indirect reporter systems, basic research concept versus clinically applicable probes, etc.)
Audience Description:
This course is designed for physicists, chemists/molecular biologists, biochemists, biologists, pharmacologists and physicians with interest in imaging technologies/fusion of MRI with other modalities; design of molecular imaging probes; application for (early) diagnostics, staging, evaluation of therapy; and responses (proof of therapeutic principle). This is a basic education course, and no special experience is required, although some experience in exposure to imaging technologies, basic knowledge in chemistry and biology would be helpful.


Saturday, 6 May 08:00 - 17:50
08:00 Introduction Markus Rudin, Ph.D.
08:35 Imaging Technologies I: Physical Principles, Technical Issues Allan Johnson, Ph.D
09:10 Imaging Technologies II: Comparison of Techniques, Strengths/Weaknesses, Fusion Umar Mahmood, M.D., Ph.D.
09:45 Combined Technologies: MRI/PET, PET/CT, MRI/Optical Instrumental Aspects Arion Chatziioannou, Ph.D.
10:20 Break - Meet the Teachers
Probe Design
10:40 Concepts of Probe Design I: Physical Principles of Reporter Moieties Silvio Aime, Ph.D.
11:15 Concepts of Probe Design II. Design of Target-Specific Probes Klaas Nicolay, Ph.D.
11:50 Combined Technologies: Multimodal Probes Natarajan Raghunand, Ph.D.
12:25 Break - Meet the Teachers
Biomedical Applications: General
13:45 Non-Invasive Imaging of Cell Signaling Alnawaz Rehemtulla, Ph.D., M.S.C.
14:20 Imaging the Function of Gene Products Gary Luker, M.D.
14:55 Monitoring Cell Migration Jeff W .M. Bulte, Ph.D.
15:30 Break - Meet the Teachers  
Biomedical Applications: Specific
15:50 Molecular Imaging in Drug Research Nick Van Bruggen, Ph.D.
Molecular Imaging and Atherosclerosis
Zahi A. Fayad, Ph.D.
17:00 Molecular Imaging in Experimental Therapeutics of Cancer Brian D. Ross, Ph.D.
  17:35 - 17:50 - Meet the Teachers