Diffusion and Perfusion Methodology
Xavier G. Golay, Derek K. Jones, Organizers

Saturday, 6 May, 08:30 - 18:15


This one-day course covers basic to advanced topics in both perfusion and diffusion MRI (including diffusion tensor imaging), starting with the underlying theory and biophysical underpinnings, through to clinical/clinical research applications. En route, techniques for encoding and acquiring MR data suitable for perfusion and diffusion quantification will be discussed, together with comparisons/critiques of methods for subsequent post-acquisition analysis. Pitfalls and artifacts will be covered, and emerging research areas/cutting edge techniques highlighted.

Educational Objectives:
Upon completion of this course, participants should be able to:
• Explain the theoretical basis and biophysical underpinnings of perfusion- and diffusion-based MR techniques;
• Compare and contrast the different approaches to encoding and acquiring MR data for quantification of diffusion and perfusion in vivo;
• Select the appropriate imaging sequence for a diffusion- and/or perfusion-based imaging study;
• Recognize the influence of exchange on diffusion and perfusion measurements;
• List the types of artifacts found in diffusion and perfusion image data and recognize limitations of perfusion and diffusion imaging   techniques; and
• Identify the role of diffusion and perfusion imaging techniques in clinical and clinical research applications.

Audience Description:
This course is designed for anyone who wants to develop a solid understanding of perfusion and diffusion MR imaging techniques. It is especially designed for Ph.D. candidates, postdoctoral students, and residents who have a working knowledge of MR physics, that includes basic concepts such as phase, susceptibility etc., and who are facile with basic calculus. It would also benefit researchers who have expertise in one of the two areas (perfusion or diffusion) and wish to expand their knowledge base to include complementary techniques.

08:30 Theory of Diffusion Peter J. Basser, Ph.D.
09:05 Biophysical Underpinnings of Diffusion Christian Beaulieu, Ph.D.
09:40 Tensor Encoding / Decoding Derek K. Jones, Ph.D.
10:15 Break - Meet the Teachers    
10:40 Sequences for Diffusion MRI James G. Pipe, Ph.D.
11:15 Artifacts and Pitfalls in Diffusion MRI Carlo Pierpaoli, M.D.
12:00 DSI/ Qball/ GDTI and Tractography Andrew L. Alexander, Ph.D.
12:40 Break    
12:40 - 13:00 - Meet the Teachers    
13:55 Theory of Perfusion Measurements Leif Østergaard, M.D., Ph.D.
14:30 DSC Perfusion (with Pitfalls) Fernando Calamante, Ph.D.
15:05 ASL Perfusion - Pulsed/Cont. Afonso C. Silva, Ph.D.
15:40 Break - Meet the Teachers     
16:15 New Ideas in Perfusion Xavier G. Golay, Ph.D.
16:50 Exchange Greg J. Stanisz, Ph.D.
17:25 Clinical Applications of Diffusion/Perfusion MRI: A Review Jeffry R. Alger, Ph.D.
18:00 - 18:15 - Meet the Teachers