Experimental Methods in MR of Cancer
Martin O. Leach, Anwar Padhani, Organizers

Sunday 7 May, 08:30 - 17:15

This one-day course aims to provide an introduction to and outline of developing MR techniques for non-invasively, experimentally or clinically assessing the effects of molecular processes contributing to or controlling the development of cancer. MR measurement methods will be described and explained in the context of these molecular processes, together with associated laboratory or clinical methods for directly evaluating or inhibiting cellular processes or genotype. These approaches are relevant to diagnosis, assessment of tumor grade, and likelihood of metastatic spread, and to the pre-clinical and clinical assessment of novel anti-cancer therapies.

Educational Objectives:
Upon completion of this session participants should be able to:
• Describe how MRS can demonstrate upregulation or inhibition of important pathways in cancer, in cell and xenograft models;
• Explain the role of choline in cellular metabolism, what MRS shows and how it may be affected by the cancer phenotype and treatment;
• List clinical applications of MR spectroscopy;
• Describe how contrast agents can be used to evaluate vascular function, and how physiological and other modelling parameters can be derived by the use of models;
• Explain the use of intrinsic contrast mechanisms to evaluate vascular function;
• Describe hypoxia in the context of cancer, identifying methods of assessing hypoxia using MR;
• Describe clinical applications relating to tumor vascular support;
• Describe how MAS can be used to assess tumors;
• Identify the likely MR changes resulting from apoptosis; and
• Describe how diffusion measurements can provide information on cancer in experimental models and in patients, and how diffusion may change with treatment.

Audience Description:
This course is designed for those with degree level education in physical, biological or medical sciences, an interest in cancer, and whose current work may be in research training, practice, or clinical training or practice. No special experience is required.

I Cellular Pathways and Processes as Cancer Targets    
8:30 Evaluating Pathways, Inhibition and Regulation Using MRS Sabrina M. Ronen, Ph.D.
9:00 Choline Metabolism: Meaning and Significance Hadassa Degani, Ph.D.
9:30 Clinical applications of magnetic resonance spectroscopy Arend Heerschap, Ph.D.
10:00 Break - Meet the Teachers    
II Tumor Vasculature in Development and Treatment    
10:30 Measuring Vascular Properties Using Contrast Agents Martin O. Leach, Ph.D.
11:00 Tracer Kinetic Models: Extracting Physiological Vascular David L. Buckley, Ph.D.
11:30 Measuring Vascular Properties Using Intrinsic Contrast Gregory S. Karczmar, Ph.D.
Mechanisms (inc BOLD)    
12:00 Break    
12:00 - 12:15 - Meet the Teachers    
13:30 Hypoxia and Its Assessment Ralph P. Mason, Ph.D.
14:00 Clinical applications of MR methods that assess  Anwar Padhani, M.R.C.P., F.R.C.R.
tumor vascular functionality    
III New Methods for Diagnosis and Evaluation    
14:30 Associating MR Findings with MR Gene and Protein Samira Guccione, Ph.D.
15:00 Break - Meet the Teachers    
15:30 Diagnosis of Cancer Using MAS Ingrid S. Gribbestad, Ph.D
16:00 Apoptosis: MR Consequences Risto A. Kauppinen, M.D., Ph.D.
16:30 Diffusion MRI:  A biomarker for cancer treatment response Brian D. Ross, Ph.D.
17:00 Adjournment     
17:00 - 17:15 - Meet the Teachers