MRS of Cancer Cell Extracts and Cultures

Hall 7     14:00 - 16:00         Chairs: Martin O. Leach and Sabrina M. Ronen


Prog #

14:00 121.

Detection of Metabolic Effects of Fatty Acid Synthase Inhibition by Magnetic Resonance Spectroscopy

James Ross1, William P. Tong1, Kumaralal Kaluarachchi1, Sabrina M. Ronen1

1The University of Texas MD Anderson Cancer Center, Houston, Texas, USA


14:10 122.

13C and 31P NMR Spectroscopy in Perfused Mouse Liver: A Novel Method for Investigating Effectors of Hepatic

Fatty Acid Metabolism

Corin O'Dell Miller1, Sheila M. Cohen1, Haiying Liu1, Robert W. Myers1

1Merck, Rahway, New Jersey, USA


14:20 123.

13C MRS Detection of Increased Choline Metabolism Following HDAC Inhibition

Madhuri Sankaranarayanapillai1, Kumaralal Kaluarachchi1, Sabrina M. Ronen1

1U.T. M.D. Anderson Cancer Center, Houston, Texas, USA


14:30 124.

Assessing Choline Kinase Activity in Cancer Cells Using a 31P NMR Enzymatic Assay

Cristina Gabellieri1, Thomas R. Eykyn1, Yann Jamin1, L. Elizabeth Jackson1, Nada M.S. Al-Saffar1, Mounia Beloueche-Babari1, Geoffrey S. Payne1, Martin O. Leach1

1The Institute of Cancer Research, Royal Marsden NHS Foundation Trust, Sutton, Surrey, UK


14:40 125.

PI3K Inhibition Using a Novel Inhibitor Deregulates Choline Kinase Resulting in PC Depletion Detected by MRS

Nada M.S. Al-Saffar1, Laura Elizabeth Jackson1, Florence Raynaud2, Ana Ramírez de Molina3, Juan Carlos Lacal3, Paul Workman2, Martin Osman Leach1

1The Institute of Cancer Research and The Royal Marsden NHS Foundation Trust, Sutton, Surrey, UK; 2The Institute of Cancer Research, Sutton, Surrey, UK; 3Instituto de Investigaciones Biomédicas, Madrid, Spain

14:50 126.

Lactate/Creatine Ratio Tracks with HIF-1 Alpha Accumulation in High-Grade Astrocytoma Cells

Rabia Siddiqi1, Maria Louisa Garcia-Martin2, Christopher Sundberg1, Samson Jarso1, Tracy Richmond McKnight1

1University of California, San Francisco, California, USA; 2IIB "Alberto Sols" CSIC-UAM, Madrid, Spain


15:00 127.

Quantification of Components of Bile Acids in Human Bile and Proton HR-MAS Spectroscopy of Gall Bladder

Tissue: A Route for Diagnosis of Gall Bladder Malignancy

Bagganahalli Siddaramaiah Somashekar1, Omkar Basavnappa Ijare1, Gowda Ajjapagowda Naganagowda1, Ajay Sharma2, Vinay K. Kapoor2, Raja Roy3, Chunni Lal Khetrapal1

1Sanjay Gandhi Postgraduate Institute of Medical Sciences campus, Lucknow, UP, India; 2Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, UP, India; 3Central Drug Reserach Institute, Lucknow, UP, India


15:10 128.

Discrimination of Malignant Ascites from Cirrhosis Associated Ascites in a Multivariate Analysis Model:

1H NMR Analysis of Ascitic Fluid

Lakshmi Bala1, Abhinav Sharma2, Radha Krishna Yellapu2, Raja Roy3, Gour Choudhuri2, Chunni Lal Khetrapal1

1Sanjay Gandhi Post-Graduate Institute of Medical Sciences Campus, Lucknow, Uttar Pradesh, India; 2Sanjay Gandhi Post-Graduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India; 3Central Drug Research Institute, Lucknow, Uttar Pradesh, India

15:20 129.

Biochemical Characterization of Lymphadenopathy in  Tuberculosis, Sarcoidosis and Metastasis Using in Vitro MRS

Uma Sharma1, S.M. Raashid Ali1, Arvind Kumar1, N R. Jagannathan1

1All India Institute of Medical Sciences, New Delhi, Delhi, India


15:30 130.

Broadband Proton-Decoupled Proton Spectroscopy of Cancer Cell Extract - not available

Andrew J. Pell1, Richard Anthony Edward Edden2, 3, Ulrich L. Günther4, James Keeler1

1University of Cambridge, Cambridge, UK; 2The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA; 3Kennedy Krieger Institute, Baltimore, Maryland, USA; 4University of Birmingham, Birmingham, UK


15:40 131.

Susceptibility-Matched Multiwell Plates for High-Throughput Screening by MR Imaging and Spectroscopy

Kenneth W. Fishbein1

1National Institutes of Health, Baltimore, Maryland, USA


15:50 132.

Simultaneous Optical and MR Imaging of Window Chambers

Arthur F. Gmitro1, Yuxiang Lin1, Dominique L. Jennings1, Robert Gatenby1

1University of Arizona, Tucson, Arizona, USA