CNS Animal Models: Novel Imaging

Stage Hall     13:30 - 15:30         Chairs: Mathias Hoehn and Malcolm J. Avison


Prog #

13:30 308.

Association of Blood-Brain-Barrier Permeability with Future Development of Brain Atrophy:

A Longitudinal Voxel-Based Morphometry (VBM) Study in a Canine Aging Model

Min-Ying Su1, Kevin Head1, Long Vu1, Bruce A. Muggenburg2, Orhan Nalcioglu1, Elizabeth Head1

1University of California, Irvine, California, USA; 2Lovelace Respiratory Research Institute, Albuquerque, New Mexico, USA


13:40 309.

An Index of Blood-Brain Barrier Permeability Measured by Serial MRI in Experimental Stroke

Catherine A. Mallik1, Diana Cash1, Michel Bernanos1, Kim O'Toole1, Maria Ashioti1, John S. Beech2, Elaine Irving3, Steve R. Williams1

1Institute of Psychiatry, London, UK; 2University of Cambridge, Cambridge, UK; 3GlaxoSmithKline Research and Development Limited, Harlow, UK


13:50 310.

Assessment of Brain Microstructure in a Transgenic Mouse Model of β-Amyloid Deposition

Maria F. Falangola1, 2, Craig Branch1, Jens H. Jensen2, Caixia Hu2, Liang Xuan2, Karen Duff1, Randy Nixon1, 2, Joseph A. Helpern1, 2

1The Nathan S. Kline Institute for Psychiatric Research, Orangeburg, New York, USA; 2New York University School of Medicine, New York, New York, USA

14:00 311.

Correlating Longitudinal In Vivo Images of Beta-Amyloid Plaques with Morris Water Maze Test

Results in a Mouse Model of Alzheimer’s Disease

Jonathan D. Thiessen1, Kathryn A. Collister2, 3, Laryssa M. Kurjewicz1, 4, Carol Readhead5, Marc R. Del Bigio6, Benedict C. Albensi2, 3, Melanie Martin1, 2

1University of Winnipeg, Winnipeg, Manitoba, Canada; 2University of Manitoba, Winnipeg, Manitoba, Canada; 3St. Boniface Research Centre, Winnipeg, Manitoba, Canada; 4University of Western Ontario, London, Ontario, Canada; 5Caltech, Pasadena, California, USA; 6University of Manitoba, Winnipeg, Manitoba, Canada

14:10 312.

Evidence for Cortical Hypoperfusion by Quantitative Arterial Spin Labeling Perfusion MRI in a Mouse

Model of Alzheimer’s Disease

Nadine El Tannir El Tayara1, Frank Kober2, Patrick Cozzone2, Andreas Volk1, Marc Dhenain1, 3

1Institut Curie, Inserm U759, Orsay, France; 2CRMBM, UMR CNRS 6612, Marseille, France; 3CEA-CNRS URA  2210, Orasy, France

14:20 313.

Manganese-Enhanced MRI of Severe Hypoxic-Ischemic Injuries in Neonatal Rat Model

Jian Yang1, Da Ma1, Yanxin Wang2, Pek Lan Khong2, Ed Xuekui Wu1

1The University of Hong Kong, Pokfulam, Hong Kong; 2Queen Mary Hospital, University of Hong Kong, Pokfulam, Hong Kong

14:30 314.

Molecular Imaging of Endothelial Activation in Acute Stroke Using a Targeted Iron Oxide Nanoparticle

Contrast Agent

Albert Jin1, David Rushforth2, Rana Filfil3, Ursula Tuor2, Feng Ni3, Tadeusz Foniok2, David Kirk2, Kumud Deka2, Philip A. Barber1

1University of Calgary, Calgary, Alberta, Canada; 2Institute of Biodiagnostics (West), National Research Council of Canada, Calgary, Alberta, Canada; 3Biotechnology Research Institute, National Research Council of Canada, Montreal, Quebec, Canada


14:40 315.

Correlation of Changes in Venous Cerebral Blood Flow After Trauma in Rats Measured by

Susceptibility-Weighted Imaging and Fractional Anisotropy in Diffusion Tensor Imaging

Yimin Shen1, Zhifeng Kou1, Mark E. Haacke1, 2, Nisrine Zakaria3, Srinivasu Kallakuri3, John Cavanaugh3, Yingjian Yu1, Jiani Hu1

1Wayne State University School of Medicine, Detroit, Michigan, USA; 2MRI Institute of Biomedical Research, Detroit, Michigan, USA; 3Wayne State University, Detroit, Michigan, USA

14:50 316.

A MRI Investigation of Cerebral Perfusion Response to Hypothermia in Ischemic Rats with a

MR Compatible Regional Brain Temperature Manipulation System

Qingwei Liu1, Hongyu An1, Weili Lin1

                               1UNC-CH, Chapel Hill, North Carolina, USA


15:00 317.

QMT Estimated Pool Size Ratio and DTI Derived Radial Diffusivity Reflect the Integrity of Myelin

Sheath in Mice

Xiawei Ou1, Shu-Wei Sun2, Hsiao-Fang Liang2, Daniel Frank Gochberg1, Sheng-Kwei Song2

1Vanderbilt University, Nashville, Tennessee, USA; 2Washington University School of Medicine, St. Louis, Missouri, USA


15:10 318.

Hybrid Diffusion Imaging in a Brain Model of Dysmyelination

Yu-Chien Wu1, Andrew L. Alexander1, Ian D. Duncan1, Aaron S. Field1

1University of Wisconsin-Madison, Madison, Wisconsin, USA


15:20 319.

High Resolution Myelin Water Measurements in Rat Spinal Cord

Piotr Kozlowski1, Andrew C. Yung1

1UBC MRI Research Centre, Vancouver, BC, Canada