Advances in Contrast Agents
Organizers:  Silvio Aime, Ph.D., Robert Muller, Ph.D.
Skill Level: Intermediate


This one-day course will tackle the major recent achievements in the field of contrast agent science, including basic developments and the most relevant applications.  It will provide an overview of the innovation in the field starting from the improvements attained with the classical T1 and T2 agents, up to outstanding progress made with CEST (Chemical Exchange Saturation Transfer) and hyperpolarized agents. 

Educational Objectives 

Upon completion of this course, participants should be able to:
•  Describe the characteristics of the main classes of MRI Contrast Agents;
•  Select the best contrast agent for a given application;
•  Compare the advantages and disadvantages of a given class of contrast agents for a given application;
•  Demonstrate the feasibility of a new MRI application by using a suitable contrast agent;
•  Compare the relative sensitivity of the different classes of contrast agents;
•  Design cellular labeling experiments;  and
•  Predict the behavior of different contrast agents in perfusion, flow and vascular permeability investigations.

Audience Description 

This course is designed for chemists, biologists and physicians with a strong interest in basic science.  Both researchers interested in using contrast agents in preclinical investigations, and clinicians who want to understand the basis for the behavior of contrast agents (including agents whose development is still far from application in clinical settings) are the target candidates.

The final five minutes of each  presentation will be reserved for questions.  
Tuesday, 22 May  
07:00 T1 and T2 Relaxation Enhancement Probes:  The State of the Art Peter Caravan, Ph.D.
07:30 CEST Agents A. Dean Sherry, Ph.D.
08:00 Adjournment  
Wednesday, 23 May  
07:00 Responsive Agents Enzo Terreno, Ph.D.
07:30 MEMRI Annemie van der Linden, D.Sc.
08:00 Adjournment  
Thursday, 24 May  
07:00 Hyperpolarized Agents Klaes Golman, Ph.D.
07:30 Magnetic Cellular Labeling Sébastien Boutry, Ph.D.
08:00 Adjournment  
Friday, 25 May  
07:00 Clinical Applications of Iron Oxide Particles Claire Corot, Ph.D.
07:30 The Future of Paramagnetic Nanoparticles Gregory M. Lanza, M.D., Ph.D. 
08:00 Adjournment