Pre-Clinical Evaluation of Tumor Response

Dachgarten     10:30 - 12:30         Chairs: Simon P. Robinson and Nada Al-Saffar


Prog #

10:30 463.

Evaluating Carboxypeptidase G2 (CPG2) Based Gene-Directed Enzyme Prodrug Therapy Using19F Magnetic

Resonance Spectroscopy: 3,5-Difluorobenzoyl-Glutamic Acid as a Potential In Vivo reporter of CPG2 Activity

Yann Jamin1, Thomas R. Eykyn1, Simon P. Robinson1, Caroline J. Springer2, Martin O. Leach1, Geoffrey S. Payne1

1The Institute of Cancer Research and Royal Marsden NHS Trust, Sutton, Surrey, UK; 2The Institute of Cancer Research, Sutton, Surrey, UK

10:42 464.

Evaluation of Vector Mediated Gene Therapy of Experimental Gliomas Using Multi-Modal Imaging Techniques

Uwe Himmelreich1, Hrvoje Miletic2, Yannic Waerzeggers1, Martina Deckert2, Alexandra Winkeler1, Mathias Hoehn1, Andreas Jacobs1

1Max-Planck-Institute for Neurological Research, Cologne, Germany; 2University of Cologne, Cologne, Germany

10:54 465.

Molecular Imaging of Lentiviral-Mediated Silencing of Choline Kinase as Gene Therapy in a Human

Breast Cancer Xenograft

Kristine Glunde1, Balaji Krishnamachary1, Flonne Wildes1, Venu Raman1, Zaver M. Bhujwalla1

1The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA

11:06 466.

Correlation Between Single Quantum and Triple-Quantum-Filtered 23Na MRI Signal Intensities, Water ADC

and Histology Changes in Control and 5-Fluorouracil Treated RIF-1 Tumors

A Babsky1, H Zhang1, SK K. Hekmatyar1, N Bansal1

1Indiana University, Indianapolis, Indiana, USA

11:18 467.

MRI Evaluation of Tumor Physiological Response to Combretastatin A4 Phosphate: Correlation with a

Combined Radiation Response

Dawen Zhao1, Lan Jiang1, Ralph P. Mason1

1University of Texas Southwestern Medical Center, Dallas, Texas, USA

11:30 468.

Validation of EPSI Angiography by Image Co-Registration

Chad R. Haney1, Charles A. Pelizzari1, Sean Foxley1, Marta Zamora1, Devkumar Mustafi1, Maria Tretiakova1, Terry S. Li1, Xiaobing Fan1, Gregory S. Karczmar1

1University of Chicago, Chicago, Illinois, USA

11:42 469.

Treatment with the Novel PI3K Inhibitor PX-866 Results in 1H  MRS Detectable Changes in a Glioma Model In Vivo

Sabrina M. Ronen1, Jim Banskon1, Dimpy Koul1, Madhuri Sankaranarayanapillai1, Douglas Webb1, Charles Kingsley1, Jorge Delacerda1, Jennifer Edge1, Alfred Yung1, Garth Powis2

1U.T. M.D. Anderson Cancer Center, Houston, Texas, USA; 2U.T. M.D. Anderson Cancer, Houston, Texas, USA

11:54 470.

Imaging Immune Response In Vivo: Cytolytic Action of Genetically Altered T-Cells Directed to Glioblastoma Multiforme

Jelena Lazovic1, Evette Ferkassian2, Brenda Aguilar2, Michael C. Jensen2, Andrew Raubitschek2, Russell E. Jacobs1

1California Institute of Technology, Pasadena, California, USA; 2City of Hope National Medical Center, Duarte, California, USA

12:06 471.

Metabolite Profiling Using 1H-HRMAS NMR Spectroscopy of the Response to Methionine Stress in a

Malignant Melanoma Model

Samuel Guénin1, Aicha Demidem1, Jean Claude Claude Madelmont1, Daniel Morvan1, 2

1Inserm 484, Clermont-Ferrand, France; 2Centre Jean Perrin, Clermont-Ferrand, France

12:18 472.

Disorders in Methylated Species in Response to Nitrosourea in a Melanoma Tumor Model: Demonstration

Using  1H-13C HRMAS NMR Spectroscopy and L-[methyl-13C]methionine

Aicha Demidem1, Samuel Guénin1, Jean-Claude Madelmont1, Daniel Morvan1, 2

1Inserm 484, Clermont-Ferrand, France; 2Centre Jean Perrin, Clermont-Ferrand, France