MRS Studies on Animal Models of Non-Oncological Disease

Dachgarten     10:30 - 12:30         Chairs: Hoby P. Hetherington and Christoph Segebarth


Prog #

10:30 711.

Single-Voxel 1H MRS of the Rat Brain: Effect of Anesthesia

Isabelle Iltis1, Dee M. Koski1, Kamil Ugurbil1, Pierre-Gilles Henry1

1University of Minnesota, Minneapolis, Minnesota, USA


10:42 712.

Neurochemical Changes in the Rat Brain with STZ-Induced Diabetes Using In Vivo 1H MR Spectroscopy at 9.4 T

Wen-Tung Wang1, Sang-Pil Lee1, Irina V. Smirnova1, In-Young Choi1

1University of Kansas Medical Center, Kansas City, Kansas, USA


10:54 713.

Short-Term Metabolic Changes in Rat Brain After Intravenous CDP-Choline Administration Studied by Means

of Localised 31P and 1H MR Spectroscopy In Vivo

Piotr Kulinowski1, 2, Marzena Labak1, Katarzyna Majcher1, Magdalena Herbik3, Pawel Grieb3, Andrzej Jasinski1, 2

1Institute of Nuclear Physics PAS, Kraków, Poland; 2Pedagogical University, Kraków, Poland; 3Medical Research Centre PAS, Warszawa, Poland


11:06 714.

Combination of 18FDG-PET, 13C MRS and 31P MRS Provides a Highly Consistent Picture of Brain Energy

Metabolism, from Glucose Breakdown Up to ATP Synthesis

Myriam Chaumeil1, Julien Valette1, Martine Guillermier1, Anne Sophie Herard1, Gilles Bloch1, Philippe Hantraye1, Vincent Lebon1, 2

1CEA-CNRS, Orsay, France; 2CEA-Neurospin, Gif-sur-Yvette, France

11:18 715.

Towards a Clinically Feasible Measurement of TCA Cycle Rates: A Novel Approach for Mathematical Modeling

Kai Uffmann1, Rolf Gruetter1, 2

1Ecole Polytechnique Fédéral de Lausanne (EPFL), Lausanne, Switzerland; 2Universities of Lausanne and Geneva, Switzerland


11:30 716.

Effects of PCP on the Prefrontal Cortex Metabolism in Intact, Anesthetized Rats

Isabelle Iltis1, Dee M. Koski1, Lynn Eberly1, Dinesh Kumar Deelchand1, Julien Valette1, Kelvin O. Lim1, Kamil Ugurbil1, Pierre-Gilles Henry1

1University of Minnesota, Minneapolis, Minnesota, USA


11:42 717.

Acetate Utilization Is Rate-Limited in the Rat Brain

Dinesh K. Deelchand1, D. M. Koski1, Alexander Shestov1, K. Ugurbil1, P-G. Henry1

1Center for Magnetic Resonance Research, Minneapolis, Minnesota, USA

11:54 718.

Short-Echo-Time 1H MRS of the Mouse Lacking Brain-Specific Glutamate-Dehydrogenase

Vladimir Mlynarik1, Ingrid Kohler1, Francesca Frigerio2, Pierre Maechler2, Rolf Gruetter1, 3

                               1Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland; 2University Medical Center,
                        Geneva, Switzerland; 3Universities of Lausanne and Geneva, Switzerland


12:06 719.

Effects of Fetal Nicotine, Dexamethasone Exposure and Caloric Restriction on the Neurochemical Profile

of the Postnatal Rat

Nicolas Kunz1, Emily Jane Camm2, Ingrid Kohler3, Stéphane V. Sizonenko2, Michel L. Aubert2, Rolf Gruetter1, 4, Petra S. Hüppi2

1Laboratory of functional and metabolic imaging, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland; 2Division of Child Growth & Development, Dept. of Pediatrics, University of Geneva, Geneva, Switzerland; 33Department of Radiology, University Lausanne, Lausanne, Lausanne, Switzerland; 4Departments of Radiology, Universities of Lausanne and Geneva, Switzerland


12:18 720.

Effects of Acute Serotonin Elevation on Brain Glucose and Neurotransmitter Metabolism:

A 13C MRS Study in Rats of Citalopram Administration

Steve Ross Williams1, Grzegorz Juszczak2, Carmen De-Groote1, Artur H. Swiergiel2, Bill Deakin1

1The University of Manchester, Manchester, UK; 2Polish Academy of Sciences, Wolka Kosowska, Poland