Neurodegenerative Disease: From Animal to Man

Hall 15.2/Stockholm     10:30 - 12:30         Chairs: Anne-Marie Van der Linden and Luis Marti-Bonmati


Prog #

10:30 928.

Diffusion Tensor Imaging Reveals Nigrostriatal Degeneration in the 6-Hydroxydopamine Rat Model for Parkinson’s Disease

Nadja Van Camp1, Ines Blockx1, Marleen Verhoye1, Veerle Baekelandt2, Jan Sijbers1, Annemie Van der Linden1

1University of Antwerp, Wilrijk, Antwerp, Belgium; 2University of Leuven, Leuven, Belgium


10:42 929.

Diffusion Tensor Imaging Measures Therapeutic Effects in a Mouse Model of Niemann-Pick Type C Disease

at 23 Days of Age

Silvia Lope-Piedrafita1, 2, Chad M. Hicks1, Robert J. Gillies1, Robert P. Erickson1, Theodore P. Trouard1

1University of Arizona, Tucson, Arizona, USA; 2Universidad Autónoma de Barcelona, Cerdanyola del Valles, Barcelona, Spain


10:54 930.

Neurochemical Changes in the Early Stage of Huntington’s Disease Progression Studied in Transgenic

Mice Using 1H and 31P NMR Spectroscopy

Ivan Tkac1, Pierre-Gilles Henry1, Janet M. Dubinsky1

1University of Minnesota, Minneapolis, Minnesota, USA


11:06 931.

Study of Brain Metabolite Change in Amyotrophic Lateral Sclerosis Using TE-Averaged PRESS

Jing Han1, Lin Ma2

1Huanhu Hospital, Tianjin, People’s Republic of China; 2PLA General Hospital, Beijing, People’s Republic of China


11:18 932.

Multimodality Voxel-Based MRI Study: Possible Tool for Disease Diagnosis and Monitoring in ALS

Don C. Bigler1, Byeong-Yeul Lee1, Helen E. Stephens1, Collin M. Torok1, J. Ryan Olson2, Jianli Wang1, Kevin R. Scott1, Qing X. Yang1, Zachary Simmons1, Michael B. Smith1

1Penn State Milton S. Hershey Medical Center, Hershey, Pennsylvania, USA; 2Memorial Hospital, York, Pennsylvania, USA

11:30 933.

Longitudinal Changes in Amyotrophic Lateral Sclerosis Detected by Diffusion Tensor Imaging and MR Spectroscopy

Sumei Wang1, Sanjeev Chawla1, John H. Woo1, Lauren B. Elman1, Leo F. McCluskey1, Harish Poptani1, Elias R. Melhem1

1University of Pennsylvania, Philadelphia, Pennsylvania, USA

11:42 934.

fMRI Reveals Altered Auditory Sensory Integration in Manifest and Premanifest Huntington’s Disease

Bettina Pfleiderer1, Anne Habbel1, Jürgen Audrich2, Walter Heindel1, Carsten Saft2

1University Hospital Münster, Münster, Germany; 2University Hospital Bochum, Germany

11:54 935.

Evaluation of Contrast Mechanisms in the Substantia Nigra, Red Nucleus and Adjacent Brain Stem Structures at 7T

Peter A. Wassenaar1, Georgeta Mihai1, Amir M. Abduljalil1, Donald W. Chakeres1, Michael V. Knopp1, Petra Schmalbrock1

1The Ohio State University, Columbus, Ohio, USA


12:06 936.

Brain Iron and Neuronal Integrity in Patients with Parkinson’s Disease Probed by Novel MRI Contrasts

Shalom Michaeli1, Gulin Oz1, Dennis J. Sorce1, Michael Garwood1, Kamil Ugurbil1, Stacy Majestic, Paul Tuite

1CMRR, University of Minnesota, Minneapolis, Minnesota, USA


12:18 937.

High Contrast Susceptibility Weighted Imaging: Reliable Unwrapping Susceptibility Technique (RUST SWI)

Improved Visualization of Midbrain Nuclei for Deep Brain Stimulation

Geoffrey S. Young1, Nan-kuei Chen2

1Brigham  and Womens Hospital, Boston, Massachusetts, USA; 2Brigham and Women's Hospital, Boston, Massachusetts, USA