Experimental Methods in MR of Cancer 

Skill Level: Basic-Intermediate
Anwar R. Padhani, MRCP, FRCP, Martin O. Leach, Ph.D., Organizers 

Sunday, 20 May


This one-day course will provide an introduction to important clinical needs and experimental techniques that inform on molecular processes that contribute to the development of the cancer phenotype. Measurement methods (including instrumentation, associated laboratory or clinical assessments) that interrogate deranged molecular and physiological processes at different length scales will be explained. The approaches demonstrated will be relevant to diagnosis, for the assessment of tumor aggressiveness, therapy response and resistance and will be relevant to the development of novel anti-cancer therapeutics.

Educational Objectives

Upon completion of this course, participants should be able to:

Describe how MRS can demonstrate the regulation of important pathways in cell and xenograft models of cancer and how choline MRS is affected by the
  cancer phenotype and treatment;
Describe clinical applications of MR spectroscopy and barriers to full implementation;
Explain methodologies, clinical uses, research applications and translation challenges of MR angiogenesis imaging methods;
Describe mechanism for and importance of tumor hypoxia; discuss common methods of assessment including using MR & PET; and future hypoxia
  biomarker development steps;
Explain how diffusion measurements can provide information on cancer in experimental models and in patients, and how diffusion may change with treatment; and
Describe how MAS can be used to asses tumors; and
Identify likely MR detectable changes resulting from apoptosis

Audience Description

This course is designed for:
Attendees with degree level education in physical, biological or medical sciences, interest in cancer, drug development,
  biomarkers, and who are currently involved in research training, practice, or clinical training or practice.

Distorted Metabolism    
08:30 Evaluating pathways, inhibition and regulation Using MRS - not available Sabrina M. Ronen, Ph.D.
09:00 Choline metabolism: meaning and significance Hadassa Degani, Ph.D
09:30 Clinical applications of magnetic resonance spectroscopy Arend Heerschap, Ph.D.
10:00 Break - Meet the Teachers  
Tumor Microenvironment
10:30 Extracting physiological vascular Information using  Timothy P. Roberts, Ph.D.
contrast agents    
11:00 Clinical applications of MR methods that assess tumor  Masoom A. Haider, M.D.
vascular functionality  
11:30 Hypoxia and Its assessment - not available Simon P. Robinson, Ph.D.
12:00 Break    
12:00 - 12:15 - Meet the Teachers    
13:30 Comparing MRI with PET assessments of human tumor hypoxia Anwar Padhani, MRCP, FRCR
14:00 Diffusion MRI: principles & data analysis Thomas L. Chenevert, Ph.D.
14:30 Diffusion MRI: utility in cancer management Dow-Mu Koh, M.D.
15:00 Break - Meet the Teachers  
Molecular Alterations    
15:30 Associating MR Findings with MR Gene and Protein  King C.P. Li, M.D.
16:00 Diagnosis of Cancer Using MAS Ingrid S. Gribbestad, Ph.D
16:30 Apoptosis: MR Consequences Risto A. Kauppinen, M.D., Ph.D.
17:00 - 17:15 - Meet the Teachers