Perfusion Imaging

Skill Level: Intermediate
Fernando Calamante, Ph.D., Glyn Johnson, Ph.D., Leif Østergaard, M.D., Ph.D., Organizers

Sunday, 20th May


This half day course covers basic to advanced topics in arterial spin labeling (ASL) and dynamic susceptibility contrast (DSC) based perfusion MRI , starting with the underlying theory and biophysical underpinnings, through to clinical/clinical research applications. En route, techniques for acquiring MR data suitable for perfusion quantification will be discussed, together with comparisons/critiques of methods for subsequent post-acquisition analysis. Pitfalls and artifacts will be covered, and emerging research
areas/cutting edge techniques highlighted.

Educational Objectives

Upon completion of this course, participants should be able to:
Explain the theoretical basis and biophysical underpinnings of perfusion-based MR techniques;
Compare and contrast the different approaches to acquiring MR data for quantification of perfusion in vivo;
Recognize and Select the appropriate imaging sequence for perfusion-based imaging study;
Recognize the influence of signal non-linearities and arterial input choice on DSC perfusion measurements;
List the types of artifacts found in perfusion image data and recognize limitations of perfusion imaging techniques; and
Identify the role of perfusion imaging techniques in clinical and clinical research applications.

Audience Description

This course is designed for:
• Anyone who wants to develop a solid understanding of perfusion MR imaging techniques. It is especially aimed at Ph.D. candidates,
  postdoctoral students, and residents who have a working knowledge of MR physics, that includes basic concepts such as phase,
  susceptibility etc., and who are facile with basic calculus.
• It would also benefit researchers who have expertise in the area and who wish to expand their knowledge base to include complementary
08:30 DSC Perfusion: Techniques and their shortcomings  - not available Ona Wu, Ph.D.
09:00 The Issues I: From Signal to Concentration  Matthias J. P. Van Osch, Ph.D.
09:25 The Issues II: Which Arterial Input?  Kim Mouridsen, M.Sc.
09:50 Vessel Size imaging and Permeability - not available  Kathleen M. Schmainda, Ph.D.
10:15 Break - Meet the teachers    
10:35 ASL Perfusion: Techniques - not available Matthias Guenther Ph.D.
11:00 Velocity selective ASL, Perfusion Territory Mapping   Eric C. Wong, M.D., Ph.D.
11:25 Latest ASL advances in fMRI P  Hanzhang Lu, Ph.D.
11:50 ASL: Latest advances in data acquisition  Sardha Lalith Talagala, Ph.D.
12:15 Clinical Applications and ASL/DSC comparisons  David Alsop, Ph.D.
12:50 Adjournment    
  12:50 - 13:05 Meet the teachers