Neuroimaging: What can clinicians learn from the animal model work?

Organizers: Pia C. Maly Sundgren, M.D., Ph.D., Annemie van der Linden, D.Sc.
Skill Level: Intermediate

Tuesday 6 May, Wednesday 7 May and Thursday 8 May 2008


This course of three one-hour sessions will focus on the use of MRI to diagnose or estimate the outcome of the following pathologies:
            1) Amyotrophic Lateeral Sclerosis (ALS);
            2) Stroke; and
            3) Cerebral Amyloid Angiopathy (CAA).

In each session both experimental findings and clinical work will be discussed separately. The two speakers will fine tune their findings to provide a complete picture of what is already translated to the clinical work-up and what is feasible for the future. 

Educational Objectives:

Upon completion of this course, participants should be able to:

  • Describe the main MRI methods used in experimental studies to diagnose 1) Amyotrophic Lateral Sclerosis (ALS), 2) Stroke and 3) Cerebral Amyloid Angiopathy (CAA)., and the underlying rationale;
  • Explain what is known about the underlying mechanism in ASL, stroke and CAA and which type of MRI investigations could be used for (early) diagnosis of these diseases;
  • List the main MRI methods used in the clinical setting to diagnose these diseases, and the underlying principles behind them; and
  • Make the translation from what is - and can be - done in experimental studies on ALS, stroke and CAA to what can be done clinically.

    Audience Description:

    This course is designed for physicians, neuroscientists, and engineers who are working with advanced MRI methods and are interested in learning which are the relevant MRI tools to improve their diagnostic skills/ accuracy in cases of ALS, CAA and how to estimate prognosis and clinical outcome of stroke, both in experimental and clinical environments; and students in biomedicine/ medicine who are interested in learning how and when advanced MRI techniques may be used to answer clinical questions.

    7:00 Focusing on Amyotrophic Lateral Sclerosis (ALS):  Early Diagnosis through Experimental Work Greetje Vanhoutte, Ph.D.
    7:25 Focus on Amyotrophic Lateral Sclerosis (ALS): Early Diagnosis in the Clinic Stefan Sunaert, M.D., Ph.D.
    7:50 Discussion  
    8:00 Adjournment  
    7:00 Focus on Stroke: Determining the Outcome/Prognosis Through Experimental Work Tracy D. Farr, Ph.D.
    7:25 Focus on Stroke: Determining the Outcome/Prognosis in the Clinic Susanne Wegener, M.D.
    7:50 Discussion  
    8:00 Adjournment  
    7:00 Cerebral Amyloid Angiopathy: Diagnosis through Experimental Work Thomas Mueggler, Ph.D.
    7:25 Cerebral Amyloid Angiopathy: Diagnosis in the Clinic Steven M. Greenberg, M.D.
    7:50 Discussion  
    8:00 Adjournment