Coronary MRA & Vessel Wall

Room 701 B


Chairs: David A. Bluemke and Reza Nezafat


Prog #

13:30 313. Multi-Phase Fat-Suppressed 3D SSFP for Robust Coronary Artery Imaging: Improvements Over the Single Phase Technique

Maggie M. Fung1, Vincent B. Ho2, Maureen N. Hood2, Ehud J. Schmidt3

1GE Healthcare, Bethesda, Maryland, USA; 2National Naval Medical Center, Bethesda, Maryland, USA; 3GE Healthcare, Boston, Massachusetts, USA

The proper selection of the “quiet”, motion-less phase is a critical parameter in visualizing  sharp vessels in coronary artery imaging. We show that the use of a multi-phase fat-suppressed 3D SSFP technique, which produces images at 3-4 cardiac phases, eliminates the need for accurate trigger delay selection in coronary artery imaging, and consistently produces better image quality relative to a single-phase acquisition. Intermittent fat suppression with Kaiser ramp steady state preparation was used to maintain fat suppression across multiple phases. Leading and trailing navigator were used to suppress respiratory motion that might occur within the lengthened multi-phase acquisition window.

13:42 314. 128-Channel Highly-Accelerated Breath-Held 3D Coronary MR Imaging

Ajit Shankaranarayanan1, Maggie Fung2, Phil Beatty1, Dan Blezek3, Tom Foo3, Luca Marinelli3, Randy Giaquinto3, Robert Darrow3, Eric Fiveland3, Ehud Schmidt4, Chris J. Hardy3

1GE Healthcare, Menlo Park, California , USA; 2GE Healthcare, Bethesda, Maryland, USA; 3GE Healthcare, Niskayuna, New York, USA; 4GE Healthcare, Boston, Massachusetts, USA

3D whole heart imaging specifically targeted towards coronary artery imaging with a highly accelerated breath-hold acquisition on a 128-channel system has been demonstrated here.  Such a combination may enable high-resolution CAI with greater reliability due to the possibility of simultaneously reducing, both the window in the cardiac cycle, and the total acquisition time.

13:54 315.
 [Not Available]
Diagnostic Value of Contrast-Enhanced Whole-Heart Coronary MRA at 3.0Tesla

Qi Yang1, Debiao Li, Xiaoming Bi, Jing An, Qiang Zhang, Renate Jerecic, Kuncheng Li1

1Xuanwu Hospital,Capital Medical University, Beijing, People's Republic of China

Coronary MRI at 3 Tesla imaging is attractive because the SNR gain from 1.5 to 3 Tesla can be traded to improve the spatial resolution and/or decrease the imaging time.Our study aims at evaluating  a new imaging technique at 3T for high-resolution, high-contrast visualization of coronary arteries and for the accurate detection of significant coronary artery disease.

14:06 316. Improved Coronary MRA Using Wideband SSFP at 3 Tesla with Sub-Millimeter Resolution

Hsu-Lei Lee1, Ajit Shankaranarayanan2, Gerald M. Pohost1, Krishna S. Nayak1

1University of Southern California, Los Angeles, California , USA; 2GE, Waukesha, Wisconsin, USA

Coronary artery imaging using SSFP at 3 Tesla exhibits high SNR and CNR, however off-resonance effects limit the TR and hence the achievable spatial resolution. Wideband SSFP sequences utilize an oscillating steady state to suppress off-resonance artifacts and therefore improve spatial resolution. Coronary artery images were obtained at 3T using three-dimensional navigated GRE, SSFP, and wideband SSFP sequences, with an in-plane resolution of 0.68 mm in the frequency-encoding direction. Wideband SSFP successfully suppressed banding artifacts, and is a promising approach for obtaining non-contrast, high-resolution coronary artery images at 3T with reliable image quality.

14:18 317. Contrast-Enhanced Whole-Heart Coronary MRA with Self-Timing and Respiratory Self-Gating

Peng Lai1, Xiaoming Bi2, Himanshu Bhat1, Andrew C. Larson1, Renate Jerecic2, Debiao Li1

1Northwestern University, Chicago, Illinois, USA; 2Siemens Medical Solutions, Chicago, Illinois, USA

Whole-heart contrast-enhanced coronary MRA (CE-CMRA) has been proven to be effective at 3T. However, due to the subject-dependent contrast kinetics and variations in heart rates and breathing patterns, optimal timing of data acquisition is complicated. Also, accurate measurement of breathing-induced heart motion remains critical for respiratory gating. In this study, a new technique for whole-heart CE-CMRA with both self-timing and respiratory self-gating was developed. In comparison to the conventional approach, the proposed self-timing approach can improve both SNR and CNR. The RSG method with direct heart position measurement can potentially better suppress respiratory motion than NAV.

14:30 318. MRI Detects Increased Coronary Wall Thickness in Asymptomatic Individuals:  the Multi-Ethnic Study of Atherosclerosis (MESA)

Robson Macedo1, Shaoguang Chen1, Shenghan Lai2, Steven Shea3, Ashkan Malayeri1, Moyses Szklo4, Joao Lima1, Debiao Li5, Kiang Liu, David A. Bluemke6

1Johns Hopkins, Baltimore, Maryland, USA; 2Baltimore, Baltimore, Maryland, USA; 3Siemens Medical Systems, Baltimore, Maryland, USA; 4Johns Hopkins School of Public Health, Baltimore, Maryland, USA; 5Radiology, Chicago, Illinois, USA; 6Johns Hopkins University, Baltimore, Maryland, USA

Coronary wall magnetic resonance imaging (MRI) is a noninvasive method for evaluation of arterial wall remodeling associated with atherosclerosis.  Asymptomatic participants of the Multi-Ethnic Study of Atherosclerosis (MESA) study were studied using black blood MRI.  MRI assessed coronary wall thickness was compared to computed tomography calcium score, carotid intimal-medial thickness and risk factors for coronary artery disease.  Coronary artery wall MRI detects increased coronary wall thickness in asymptomatic individuals with subclinical markers of atherosclerotic disease and in individuals with zero calcium score.

14:42 319. MR Imaging of the Coronary Vessel Wall: Comparison of Vessel Wall Characteristics in Patients with Coronary Artery Disease and Age-Matched Healthy Controls

Suzanne C. Gerretsen1, 2, Marianne E. Kooi1, 2, René M. Botnar3, Marcus Katoh4, Rob J. van der Geest5, Johannes Waltenberger1, 2, Jos M.A. van Engelshoven1, 2, Tim Leiner1, 2

1Maastricht University Hospital, Maastricht, Netherlands; 2Maastricht University, Maastricht, Netherlands; 3Technical University Munich, Munich, Germany; 4Saarland University Hospital, Homburg/Saar, Germany; 5Leiden University Medical Center, Leiden, Netherlands

The purpose of this study was to investigate differences in vessel wall characteristics at longitudinal MR coronary vessel wall imaging in patients with angiographically proven coronary artery disease (CAD) and a control group of age-matched healthy volunteers. 22 patients and 26 healthy volunteers underwent coronary vessel wall imaging. MR imaging can be used to non-invasively visualize the coronary vessel wall and to detect the presence of (sub)clinical coronary atherosclerosis. This study showed a significantly higher SI as well as increased wall thickness in patients with CAD compared to age-matched healthy volunteers. The significance of this phenomenon remains to be determined.

14:54 320. Evaluating Coronary Atherosclerotic Plaque Enhancement by Contrast-Enhanced Navigator-Gated 3D-SSFP Sequence

Tao Li1, Hong Shao Zhao1, Quan Liu Cheng1, Long Zu Cai1, Li Yang1, Hai Xi Zhao1

1PLA General Hospital, Peking, People's Republic of China

The vulnerability of coronary atherosclerotic plaques often results in cardiovascular events. Various techniques have been used in evaluating the vulnerable plaque. Contrast-enhanced MRA bright blood technique using Gd-DTPA has the capacity of visualizing human coronary atherosclerotic plaques. Enhancement of plaques can also be detected on contrast-enhanced MRA. The plaques enhancement may indicate the vulnerability. This work is to evaluate plaque enhancement using contrast-enhanced navigator-gated 3D-SSFP sequence.

15:06 321. Molecular MRI of Vascular Remodeling in a Swine Model of Coronary Injury Using an Elastin-Binding Contrast Agent

Christian von Bary1, Anne Preissel1, Elmar Spuentrup2, Alexandra Keithahn1, Sylvia Schachoff1, Simon Robinson3, Joel Lazewatsky3, Markus Schwaiger1, Joerg Hausleiter1, Rene Michael Botnar4

1Klinikum rechts der Isar, Munich, Germany; 2University Hospital Köln, Cologne, Germany; 3Bristol-Myers Squibb, North Billerica, USA; 4King's College London, London, UK

We sought to demonstrate the feasibility of imaging vascular remodeling in a porcine model of coronary injury using BMS753951, a novel elastin-binding low molecular weight contrast agent.

15:18 322. Black-Blood T1 Mapping for Quantitative Molecular Coronary Vessel Wall Imaging Using Elastine-Binding Contrast Agents

Christian Stehning1, Christian von Bary2, Anne Preissel2, Simon Robinson3, Andreas Steingötter4, Hannes Dahnke1, René Michael Botnar4

1Philips Research, Hamburg, Germany; 2Technische Universität, München, Germany; 3Bristol-Myers Squibb Medical Imaging, North Billerica, Massachusetts, USA; 4Klinikum rechts der Isar, München, Germany

An ECG-triggered, navigator-gated black blood T1 mapping sequence is presented. It allows for the quantification of an elastin-targeted contrast agent in the coronary vessel wall.