WEEKEND EDUCATIONAL COURSE
MR Physics for Physicists
Organizer: Michael H. Buonocore, M.D., Ph.D.
Skill level: Intermediate  Advanced
Saturday, 3 May 2008
Overview:This oneday course will explore the physical methods
and mathematical models that underlie nearly all research and development in MRI
and MR spectroscopy. Specific topics include:
Quantum mechanical and semiclassical models of the proton dynamics;
Spin density and equations for coupled spin systems;
Intra and intermolecular multiple quantum coherence;
Physical mechanisms of hyperpolarization;
Quantummechanical description of the spinRF coil interaction;
RF field equations and reciprocity laws at all field strengths;
Quantum mechanical and classical descriptions of T1,
T2 and
other contrast mechanisms;
Mathematical models for susceptibility contrast;
Tissue models to explain MRI contrast;
Chemical and physical principles of contrast agent design;
Mathematical description of dynamic equilibrium magnetization in fast sequences;
Description of echo formation and contrast using spin phase diagrams;
Principles of manipulation of magnetization phase for applications; and
Models and equations for RF pulse design.
Educational Objectives:
Upon completion of this course, participants should be able to:
Starting from first principles in quantum mechanics, describe and derive the
equations for spin and magnetization dynamics, and explain the semiclassical
limits of the quantum mechanical model;
Describe the spin density formalism used to model the dynamics of coupled spin
systems, and the application of this formalism to understand experiments in MR
spectroscopy, as well as experiments that reveal residual intra and
intermolecular dipolar interactions of water in tissues;
Describe the quantum mechanical and semiclassical theory of relaxation, and the
mechanisms of relaxation of protons that can result in generation of image
contrast;
Describe the physical tissue models needed to understand image contrast from
relaxation parameters, magnetization phase, microscopic susceptibility, the
action of contrast agents, and generally from cellular structure on the
miscroscopic (< 100 nanometers) and mesoscopic (1100 micron) scale; and
Describe the mathematical models used in deriving new pulse sequences and RF
pulse modulation. Specifically, describe how spin phase diagrams are used to
understand dynamic equilibrium in short tr sequences, and how these diagrams are
used for developing new sequences with new contrast dependencies. Describe the
different mathematical models used for RF pulse design, and their relative
advantages and disadvantages.Audience Description:
The course is designed for Ph.D. candidates and recent graduates in physics,
chemistry, applied mathematics, and engineering. It is also well suited to
established MR scientists who seeks a more quantitative understanding of the
physics and mathematical foundations of MRI. The individual who will benefit
most will have a graduate education MR physics, chemistry, applied mathematics,
or engineering. An individual with several years of direct MRI experience, but
without prior formal physics and mathematics training will also benefit.




Spin Physics 

8:30 
Quantum
Mechanical and SemiClassical Models of the Proton and Spin Dynamics. 
Robert W. Brown, Ph.D. 
9:00 
Spin
Density Equations for Coupled Spin Systems 
Peter S. Allen, Ph.D. 
9:30 
Understanding
Intra and
Intermolecular Multiple Quantum Coherences 
Jiahui Zhong, Ph.D. 
10:00 
Physical
Mechanisms of Hyperpolarization 
Jim M. Wild, Ph.D. 
10:30 
Break 

10:30  10:45 
Meet the
Teachers 





Signal Detection 

11:00 
Quantum
Mechanical Models of
the SpinRF Coil Interaction 
James Tropp, Ph.D. 
11:30 
Understanding RF
Field
Equations and Reciprocity Laws at All Field Strengths 
Frank Seifert, Ph.D. 
12:00 
Break 

12:00  12:15 
Meet the
Teachers 





Generation of Contrast 

13:30 
QM and
SemiClassical Models
for T1, T2, and Other Contrast Mechanisms 
Joseph J.H. Ackerman, Ph.D. 
14:00 
Mathematical
Models for Susceptibility Contrast 
E. Mark Haacke, Ph.D. 
14:30 
Tissue
Models and Their Application to Predicting MRI Contrast 
Dmitriy Yablonskiy, Ph.D. 
15:00 
Chemical and
Physical Principles of Contrast Agent Design 
Jeff W.M. Bulte, Ph.D. 
15:30 
Break 

15:30  15:45 
Meet the
Teachers 





Imaging Physics 

16:00 
Mathematical
Description of
Dynamic Equilibrium Magnetization in Fast Sequences 
Carl Ganter, Ph.D. 
16:30 
Understanding
Echo Formation
and Contrast Through Spin Phase Diagrams 
Yuval Zur, Ph.D. 
17:00 
Principles of
Manipulating
Magnetization Phase for Applications 
Michael Markl, Ph.D. 
17:30 
Models and
Equations for RF Pulse Design 
Charles L. Epstein, Ph.D. 
18:00 
Adjournment 

18:00  18:15 
Meet the
Teachers 






