| Coronaries & Aorta: Lumen & All |
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Monday 20 April 2009 |
| Room 313A |
11:00-13:00 |
Moderators: |
Matthias Stuber and Qi Yang |
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11:00 |
22. |
3T
Contrast-Enhanced Whole Heart Coronary MRA Using
32-Channel Cardiac Coils for the Detection of
Coronary Artery Disease |
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Qi Yang11,
Kuncheng Li1, Xiaoming Bi2,
Jing An3, Feng Huang4, Renate
Jerecic2, Debiao Li5
1Radiology,
Xuanwu Hospital, Beijing, China; 2Siemens
Medical Solutions; 3Siemens Mindit
Magnetic Resonance Ltd; 4Invivo
Corporation; 5Northwestern University |
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Higher study success rate
achieved by 32-channel coils substantially improved
overall accuracy of 3T coronary MRA in detecting
coronary artery disease when using the intention to
diagnose method. |
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11:12 |
23. |
In
Vivo Human Coronary Magnetic Resonance
Angiography at 7 Tesla
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Saskia Gerdina Cornelia van
Elderen1, Andrew G. Webb1,
Maarten J. Versluis1, Jos J.M. Westenberg1,
Joost Doornbos11, Nadine B. Smith1,
Albert de Roos1, Matthias Stuber2
1Radiology,
Leiden University Medical Centre, Leiden,
Netherlands; 22Radiology, Johns Hopkins
University Medical School, Baltimore, USA |
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Coronary MRA has been
implemented on a 7 tesla human system and tested on
eleven volunteers. Adaptations from protocols at
lower field strengths include the optimization of
navigators, fat suppression and vector ECG
placement, as well as volume selective power
optimization using a transmit/receive surface coil
due to the absence of available body coils at 7
tesla. MRA’s were successfully obtained from all
subjects, allowing quantitative measurements of RCA
diameter and length, as well as vessel sharpness. |
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11:24 |
24. |
3.0T
Whole Heart Coronary MR Angiography Performed as a
Part of Comprehensive Contrast Enhanced CMR Study. |
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Motonori Nagata1,
Hajime Sakuma1, Nanaka Ishida1,
Shingo Kato1, Hiroshi Nakajima2,
Masaki Ishida1, Katsuya Onishi2,
Masaaki Ito2, Kan Takeda1
1Radiology,
Mie University Hospital, Tsu, Mie, Japan; 2Cardiology,
Mie University Hospital, Tsu, Mie, Japan |
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Whole heart coronary MRA at
3T was acquired in 52 patients with suspected CAD as
apart of comprehensive CMR study. After acquiring
perfusion MRI and late gadolinium enhanced MRI,
navigator-echo gated, 3D-TFE images were obtained
with a patient-specific narrow acquisition window
(57.9ms}26.8). Acquisition of MRA was successfully
completed in all 52 patients, with averaged imaging
time of 11.4 } 4.5 minutes. On a vessel based
analysis, the sensitivity, specificity and NPV were
88%, 97% and 97%, respectively. 3.0 T coronary MRA
performed as a part of comprehensive cardiac MR
study is useful for ruling out significant CAD. |
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11:36 |
25. |
Contrast-Enhanced Whole-Heart Coronary MRA at 1.5T
in Less Than 5 Minutes Using Gradient Echo
Interleaved EPI and Double Dose of Gd-DTPA
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Himanshu Bhat1,
Sven Zuehlsdorff2, Xiaoming Bi2,
Xin Liu1, Renate Jerecic2,
Debiao Li1
1Radiology
and Biomedical Engineering, Northwestern University,
Chicago, IL, USA; 2Siemens Medical
Solutions, Chicago, IL, USA |
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A gradient echo interleaved
EPI (GRE-EPI) sequence was optimized for
contrast-enhanced whole-heart coronary MRA at 1.5T
in a scan time less than 5 minutes. This is
approximately a factor of 2 reduction in scan time
compared to current whole-heart TrueFISP protocols.
The reduced scan time made it feasible to acquire
images with a more commonly used contrast agent
Gd-DTPA instead of high relaxivity contrast agent
Gd-BOPTA. |
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11:48 |
26. |
Are We
Reconstructing the Best Images Using Navigator-Gated
3D Coronary MRA? Multiple-Image Reconstruction
Using CLAWS
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Permi Jhooti1,
Jennifer Keegan2, Klaus Scheffler1,
David Firmin2
1Radiological
Physics, University Hospital Basel, Basel,
Switzerland; 2CMR Unit, Royal Brompton
Hospital, London, UK |
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A technique is presented
which acquires a 3D-whole heart scan in the quickest
time possible for any respiratory trace (p=ns) and
enables 3 images to be reconstructed: the
most-frequent 5mm navigator window, an
end-expiratory image and an end-inspiratory image.
Previous techniques require manual window selections
which may not be optimal for scan efficiency or
image quality. This modified CLAWS approach enables
multiple-image reconstruction in the same
acquisition time as for a single image. It is not
possible to predict which image will be best. A
multi-image technique is therefore optimal,
particularly as there is no scan time loss. |
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12:00 |
27. |
Association of Coronary Calcification and Carotid
Artery Morphology: A High Resolution Magnetic
Resonance Imaging Study |
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qian zhao1, Xihai
Zhao2, Feiyu Li2, Qingjun Wang1,
Zulong Cai1, Chun Yuan2,
Jianming Cai1
1Department
of radiology, PLA General Hospital, Beijing, China;
2Department of radiology, University of
Washington, Seattle, WA, USA |
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Atherosclerosis has been
shown a systematic disease which often involves
multiple arterial vascular beds. Recently, a number
of studies demonstrated a significant correlation
between coronary and carotid atherosclerosis. This
study sought to evaluate the association between
coronary calcification and carotid artery
morphology. The results showed moderate to strong
correlation between coronary calcium score detected
by CT and carotid morphological measurements by MRI.
It indicates that patients with high coronary
calcium score may have big plaque burden in carotid
arteries. Coronary calcium score as a marker of
coronary disease is potentially capable of
predicting carotid atherosclerosis. |
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12:12 |
28. |
Multi-Slice Breathhold Phase-Sensitive Coronary
Vessel Wall Imaging at 3T
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Khaled Z. Abd-Elmoniem1,
Matthias Stuber1
1Department
of Radiology, Johns Hopkins University, Baltimore,
MD, USA |
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Black-blood coronary vessel
wall imaging is a powerful non-invasive tool for the
quantitative assessment of atherosclerotic positive
arterial remodeling. Although
dual-inversion-recovery (DIR) is the current
standard for black-blood coronary vessel wall
imaging, optimization of lumen-vessel wall contrast
is associated with competing requirements related to
TI* (blood signal nulling time), TD (period of
minimal myocardial motion), and heart rate. Because
of these constraints, the collection of multi slice
data during the same cardiac cycle is not easily
possible. For these reasons, we have exploited
phase-sensitive dual-inversion recovery (PS-DIR) and
combined it with a multi-slice spiral signal readout
for black-blood coronary vessel wall imaging.
Phantom and in vivo data are discussed. |
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12:24 |
29. |
Diagnostic Impact of Aortic MRI at 3Tesla in Acute
Stroke Patients |
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Andreas Harloff1,
Stefanie Brendecke1, Jan Simon1,
Wolf Wallis1, Dawit Assefa2,
Thomas Helbing2, Alex Frydrychowicz3,
Johannes Weber4, Cornelius Weiller1,
Jürgen Hennig3, Michael Markl3
1Neurology,
University Hospital Freiburg, Freiburg, Germany;
2Cardiology and Angiology, University
Hospital Freiburg, Freiburg, Germany; 3Diagnostic
Radiology, MR Physics, University Hospital Freiburg,
Freiburg, Germany; 4Neuroradiology,
University Hospital Freiburg, Freiburg, Germany |
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The purpose of this study
was to evaluate a dedicated multi-contrast 3D MRI
protocol for the reliable detection of aortic
high-risk plaques in the entire thoracic aorta of
acute stroke patients. Findings were compared with
transesophageal echocardiography (TEE). |
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12:36 |
30. |
In
Vivo Volumetric MRI in Drug Discovery: A
Preclinical Study of the Ezetimibe Therapeutic
Efficacy on Atherosclerotic Plaque Burden in the
Thoracic Ascending Arterial Tree in ApoE-/- Mice |
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Haiying Tang1,
Ching H. Chang2, Donna Suresch1,
Lesley A. Mcnamara2, Christopher Tong3,
Bernd Misselwitz4, Dan Zhou1,
Brett M. Connolly1, Jing Xu5,
Xun Chen2, Xiaolan Shen6,
Chunlian Zhang1, Eric L. Rickes2,
Michelle Mariano6, Karim Azer5,
Jun Wang2, Cyrille Sur1,
Donald S. Williams1, Michael Klimas1,
Andrew S. Plump1, Richard Hargreaves1,
Haiying Liu1
1Imaging,
Merck Research Laboratories, Rahway, NJ, USA; 2Cadiovascular
Disease, Merck Research Laboratories, Rahway, NJ,
USA; 3Biometrics, Merck Research
Laboratories, Rahway, NJ, USA; 4TRG
Diagnostic Imaging, Bayer Schering Pharma AG.,
Berlin, Germany; 5Applied Computer
Science & Math, Merck Research Laboratories, Rahway,
NJ, USA; 6LAR, Merck Research
Laboratories, Rahway, NJ, USA |
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Volumetric MRI of
atherosclerotic plaque in the thoracic ascending
arterial tree may provide valuable insight into
disease progression and therapeutic responses. In
this study, in vivo MRI was validated to
demonstrate the effectiveness of a potent
cholesterol absorption inhibitor, ezetimibe, on the
inhibition of the progression of atherosclerosis.
Atherosclerotic plaque burden changes in apoE-/-
mouse were monitored by longitudinal MRI using a
plaque targeting contrast agent Gadofluorine-M. MRI
plaque burden quantitation and therapeutic responses
were validated by biological approaches. The
volumetric data were evaluated to determine the most
sensitive biomarker through univariate analysis of
plaque volume, area, and thickness measurements. |
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12:48 |
31. |
Complex
Plaques in the Descending Aorta as a Potential
Source of Stroke – Visualization of Potential
Retrograde Flow Into the Supra-Aortic Arteries Using
Multi-Directional 4D Velocity Mapping at 3 Tesla |
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Andreas Harloff1,
Jan Simon1, stefanie Brendecke1,
Wolf Wallis1, Dawit Assefa2,
Alex Frydrychowicz3, Johannes Weber4,
Jürgen Hennig3, Cornelius Weiller1,
Michael Markl3
1Neurology,
University Hospital Freiburg, Freiburg, Germany;
2Cardiology and Angiology, University
Hospital Freiburg, Freiburg, Germany; 3Diagnostic
Radiology, MR Physics, University Hospital Freiburg,
Freiburg, Germany; 4Neuroradiology,
University Hospital Freiburg, Freiburg, Germany |
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Detection of the precise
localization of plaques in the descending aorta
using 3D MRI in combination with multi-directional
4D velocity mapping was used to systematically
analyze retrograde embolic pathways within the aorta
of acute stroke patients. Similar distribution of
descending aortic plaque distance and extent of
retrograde flow indicate the potential for
retrograde embolization in these patients.
Particularly, we assessed how frequently the
brachiocephalic trunk, the left common carotid
and/or subclavian artery were reached by individual
flow channels originating directly at the atheroma
in the descending aorta. |
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