| Vessel Wall Imaging |
|
Thursday 23 April 2009 |
| Room 316BC |
10:30-12:30 |
Moderators: |
Jianming Cai and J. Kevin DeMarco |
|
|
| |
|
10:30 |
599. |
High-Resolution 3D Coronary
Vessel Wall Imaging Using Spiral Image Acquisition
at 3T |
|
|
|
Miriam Wilhelmina
Lagemaat1, Markus Henningsson2,
Matthias Stuber3, Andrea J. Wiethoff2,4,
Rene M. Botnar2
1Dep. of Biomedical Engineering, Eindhoven
University of Technology, Eindhoven, Netherlands;
2NIHR Biomedical Research Centre at Guy's
& St Thomas' Hospital and King's College London,
London, UK; 3Dep. of Radiology, Johns
Hopkins University, Baltimore, MD, USA; 4Philips
Healthcare, Reigate, UK |
|
|
|
A non-invasive approach
for coronary plaque imaging would be desirable in
addition to X-ray coronary angiography. MR coronary
vessel wall and plaque imaging techniques at 1.5T
have been reported previously and were successful in
imaging the RCA and LAD vessel walls. With the wider
spread availability of high field 3T clinical
scanners and the advent of commercially available
32-channel coils, higher resolution coronary vessel
wall imaging has become feasible. In this study we
sought to implement and optimize the local inversion
pre-pulse technique on a 3T system and to obtain
higher-resolution (0.5mm) 3D black blood
cross-sectional coronary vessel wall images. |
|
|
|
|
|
10:42 |
600. |
Increasing Lipid Core Size in
Carotid Plaque Is Predictive of Cardiovascular
Events in Elder Asymptomatic Individuals Using
Contrast-Enhanced High-Resolution MRI |
|
|
|
Jianming Cai1,
Qingjun Wang1, Lin Ma1,
Youquan Cai1, Qian Zhao1
1Radiology, Chinese PLA General Hospital,
Beijing, China |
|
|
|
By using
contrast-enhanced high-resolution MRI, we studied
prospectively whether increasing lipid core predicts
future new cardiovascular events in elder
asymptomatic individuals. Each subject in the
present study was given consecutive pre and post
contrast-enhanced MRI examinations every 6-9 months
and followed up for new cardiovascular events. Our
findings show that the increasing size of lipid core
is significantly associated with the risk of the new
vascular events. Being a noninvasive and accurate
measure tool for lipid core, contrast-enhanced
high-resolution MRI may be helpful to predict future
cardiovascular events and improve the effectiveness
of therapeutic strategies. |
|
|
|
|
|
10:54 |
601. |
Quantification of Arterial
Wall Inflammation in Patients with Arteriits Using
High Resolution DCE-MRI: A Correlation Study with
18F-FDG PET-CT |
|
|
|
Clemens C. Cyran1,
Tobias Saam1, Steven Soubron1,
José G. Raya1, Katja Bochmann1,
Markus Hacker2, Axel Rominger2,
Peter Bartenstein2, Thomas Pfefferkorn3,
Michael Dichgans3, Maximilian F. Reiser1,
Konstantin Nikolaou1
1Department of Clinical Radiology, University
Hospitals Munich - Grosshadern, Munich, Germany;
2Department of Nuclear Medicine,
University Hospitals Munich - Grosshadern, Munich,
Germany; 3Department of Neurology,
University Hospitals Munich - Grosshadern, Munich,
Germany |
|
|
|
DCE-MRI was compared to
the gold standard 18F-FDG-PET-CT for its
applicability in the non-invasive quantification and
measurement of arterial wall inflammation in
patients with arteriitis in carotid and vertebral
arteries. DCE-MRI of the carotid/vertebral arteries
of 12 patients with suspected arteriitis was
acquired at 3T (2D-SR-SGRE) using a dedicated
4-channel surface coil. Patients underwent
18F-FDG-PET-CT within one week of the MRI scan.
Results showed a good correlation of DCE-MRI with
18F-FDG-PET-CT. This method might be useful in the
diagnosis of arteriitis and in monitoring
anti-inflammatory therapy. |
|
|
|
|
|
11:06 |
602. |
Minimization of MR Contrast
Weightings for the Comprehensive Evaluation of
Carotid Atherosclerotic Disease |
| |
|
Xihai Zhao1,
Jianming Cai2, Hunter Underhill1,
Minako Oikawa1, Li Dong1,
Hideki Ota1, Thomas Hatsukami3,
Chun Yuan1
1Department of Radiology, University of
Washington, Seattle, WA, USA; 2Department
of Radiology, PLA General Hospital, Beijing, China;
3Department of Surgery, University of
Washington, Seattle, WA, USA |
|
|
|
Multi-sequence MR
imaging (TOF, T1W, PDW, and T2W) has been shown
noninvasively characterizing carotid
atherosclerosis. Although the use of these multiple
contrast weightings can evaluate a spectrum of
plaque features, each contrast weighting requires
additional scan time and adds to the time required
for image analysis. To minimize MR contrast
weightings for the comprehensive evaluation of
carotid atherosclerosis is potentially capable of
reduce the scan time and cost. This study compared
three MR contrast weighting combinations in
evaluating carotid plaque features. The results
showed that comprehensive carotid plaque
interpretation can be performed with T1W, CE-T1W,
and TOF sequences. |
|
|
|
|
|
11:18 |
603. |
Multi-Spectral MRI Shows
Unorganized Thrombus One Year After Endovascular
Abdominal Aortic Aneurysm Repair |
|
|
|
Sandra Adriana
Cornelissen1,2, Maarten J. van der Laan3,
Koen L. Vincken4, Frans L. Moll3,
Willem P. Mali1, Max A. Viergever2,
Lambertus W. Bartels2
1Radiology, UMC Utrecht, Utrecht, Netherlands;
2Image Sciences Institute, UMC Utrecht,
Utrecht, Netherlands; 3Vascular Surgery,
UMC Utrecht, Utrecht, Netherlands; 4Image
Sciences Institute, UMC Utrecht, Netherlands |
|
|
|
Not all aneurysms
without endoleak after endovascular abdominal aortic
aneurysm repair (EVAR) shrink. In such cases it is
unclear whether EVAR has been successful. Therefore
it is important to further investigate this
phenomenon. Apparently, more parameters are needed
to evaluate treatment success. We present the first
results of longitudinal monitoring of thrombus
organization in patients after EVAR using
multispectral MRI. Surprisingly, one year after EVAR
unorganized thrombus is still present in the
non-luminal aneurysm sac. Its etiology and
significance is currently investigated in a larger
population. |
|
|
|
|
|
11:30 |
604. |
Thrombus Development and
Fragmentation in Rats Using Non-Enhanced MRI |
|
|
|
Abdel Bidar1,
Frank Risse1, Anna Ravnefjord2,
Susanna Pehrsson2, Arno Nauerth3,
Margareta Elg2, Paul D. Hockings1
1DECS Imaging, AstraZeneca, Molndal, Sweden;
2BioScience, AstraZeneca, Molndal,
Sweden; 3Bruker BioSpin, Ettlingen,
Germany |
|
|
|
To our knowledge this is
the first study to show the time course of thrombus
formation over the first 4 days. Maximal average
thrombus size was obtained 50 minutes after thrombus
induction with no marked decrease over the following
4 days. Thrombus fragmentation was seen in several
rats which potentially explains some of the
variability seen in thrombosis models. An excellent
correlation was found for MRI volume measurement and
wet weight. MRI can follow thrombus formation,
growth, fragmentation and dissolution in the same
animal and thus drastically reduce the number of
animals needed. |
| |
|
|
|
11:42 |
605. |
Comparison Between Three
T1-Weighted Sequences for Detection and Area
Measurement of Intraplaque Hemorrhage in Carotid
Atherosclerotic Plaque Imaging at 3 Tesla |
| |
|
Hideki Ota1,
Vasily L. Yarnykh2, Marina S. Ferguson2,
Hunter R. Underhill2, J Kevin DeMarco1,
Minako Oikawa2, Li Dong2,
Xihai Zhao2, David C. Zhu1,
Thomas S. Hatsukami3, Chun Yuan2
1Department of Radiology, Michigan State
University, East Lansing, MI, USA; 2Department
of Radiology, University of Washington, Seattle, WA,
USA; 3Department of Surgery, University
of Washington, Seattle, WA, USA |
| |
|
In this study using a
3.0T scanner, the detection and area measurement of
carotid intraplaque hemorrhage were compared amongst
three T1W sequences: 2D-FSE, 3D-SPGR, and 3D-MPRAGE.
For each T1W sequence, an experienced radiologist
identified hemorrhage blinded to histology and the
images and results from the other sequences. A total
of 198 slices in 18 arteries were matched to
histology. MPRAGE demonstrated the highest agreement
for detection and quantification of hemorrhage with
histology and the highest %-contrast of hemorrhage
among 3 weightings. This study validates the use of
MPRAGE as a fast and reliable hemorrhage-specific
sequence for 3.0T carotid plaque MRI. |
| |
|
|
|
11:54 |
606. |
An Optimized 3D Spoiled
Gradient for Hemorrhage Assessment Using
INversion Recovery and Multiple Echoes
(3D SHINE) for Carotid Plaque Imaging |
| |
|
David C. Zhu1, Hideki Ota, Anthony T. Vu2,
J. Kevin DeMarco
1Psychology and Radiology, Michigan State
University, East Lansing, MI, USA; 2GE
Healthcare, Waukesha, WI, USA |
| |
|
Intraplaque hemorrhage
into the carotid atherosclerotic plaque has been
shown to create instability and progression. We have
developed an optimized 3D inversion recovery
prepared fast spoiled gradient recalled sequence
with multiple echoes, and is now characteristically
called an optimized 3D Spoiled Gradient for
Hemorrhage Assessment Using INversion
Recovery and Multiple Echoes (3D SHINE)
for carotid plaque imaging. The sequence has been
further optimized in scan time, coverage and
black-blood effect. Pilot patient data are
presented. The T2* values appear
to be promising in characterizing the hemorrhage
type. This hemorrhage type characterization may
provide additional information on plaque
vulnerability. |
| |
|
|
|
12:06 |
607. |
Black Blood Vessel Wall
Imaging of the Lower Extremities with T2prep
Inversion Recovery: A Feasibility Study |
| |
|
Thanh D. Nguyen1,
Ryan Brown1, Matthew D. Cham1,
Pascal Spincemaille1, Priscilla A.
Winchester1, Grace Choi1,
Martin R. Prince1, Yi Wang1
1Radiology, Weill Cornell Medical College, New
York, NY, USA |
| |
|
Black blood techniques
including double inversion recovery (DIR), spatial
presaturation, and motion-sensitizing magnetization
preparation perform well in elastic arteries with
fast blood flow, but are less effective in the lower
extremities where blood flow is substantially
slower. The aim of this study is to optimize T2prep
inversion recovery (T2IR) sequence, a novel
flow-insensitive black blood technique, and to
investigate the feasiblity of T2IR fast spin echo (FSE)
for lower extremity vessel wall imaging with DIR-FSE
as a reference. T2IR was found to provide improved
robustness against slow flow artifacts at the cost
of lower SNR. Vessel wall areas obtained with DIR-FSE
and T2IR-FSE were comparable in both femoral
(p=0.28) and popliteal (p=0.1) arteries. |
| |
|
|
|
12:18 |
608. |
Imaging the Vessel Wall in
Major Peripheral Arteries Using Susceptibility
Weighted Imaging: Visualizing Calcifications |
| |
|
Qi Yang1,
Jiangtao Liu1, Samuel Barnes2,
Zhen Wu3, Kuncheng Li1,
Jaladhar Neelavalli2, Jiani Hu2,
E. M. Haacke2
1Xuanwu hospital, Beijing, China; 2Wayne
State University; 3McMaster University |
| |
|
It is possible to image
the vessel wall and calcifications with
susceptibility weighted imaging (SWI) with no need
to suppress the signal from the blood. |
|
|
|
|
|