Vessel Wall Imaging
Thursday 23 April 2009
Room 316BC 10:30-12:30


Jianming Cai and J. Kevin DeMarco

10:30 599. High-Resolution 3D Coronary Vessel Wall Imaging Using Spiral Image Acquisition at 3T
    Miriam Wilhelmina Lagemaat1, Markus Henningsson2, Matthias Stuber3, Andrea J. Wiethoff2,4, Rene M. Botnar2
Dep. of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, Netherlands; 2NIHR Biomedical Research Centre at Guy's & St Thomas' Hospital and King's College London, London, UK; 3Dep. of Radiology, Johns Hopkins University, Baltimore, MD, USA; 4Philips Healthcare, Reigate, UK
    A non-invasive approach for coronary plaque imaging would be desirable in addition to X-ray coronary angiography. MR coronary vessel wall and plaque imaging techniques at 1.5T have been reported previously and were successful in imaging the RCA and LAD vessel walls. With the wider spread availability of high field 3T clinical scanners and the advent of commercially available 32-channel coils, higher resolution coronary vessel wall imaging has become feasible. In this study we sought to implement and optimize the local inversion pre-pulse technique on a 3T system and to obtain higher-resolution (0.5mm) 3D black blood cross-sectional coronary vessel wall images.
10:42 600. Increasing Lipid Core Size in Carotid Plaque Is Predictive of Cardiovascular Events in Elder Asymptomatic Individuals Using Contrast-Enhanced High-Resolution MRI
    Jianming Cai1, Qingjun Wang1, Lin Ma1, Youquan Cai1, Qian Zhao1
Radiology, Chinese PLA General Hospital, Beijing, China
    By using contrast-enhanced high-resolution MRI, we studied prospectively whether increasing lipid core predicts future new cardiovascular events in elder asymptomatic individuals. Each subject in the present study was given consecutive pre and post contrast-enhanced MRI examinations every 6-9 months and followed up for new cardiovascular events. Our findings show that the increasing size of lipid core is significantly associated with the risk of the new vascular events. Being a noninvasive and accurate measure tool for lipid core, contrast-enhanced high-resolution MRI may be helpful to predict future cardiovascular events and improve the effectiveness of therapeutic strategies.
10:54 601. Quantification of Arterial Wall Inflammation in Patients with Arteriits Using High Resolution DCE-MRI: A Correlation Study with 18F-FDG PET-CT
    Clemens C. Cyran1, Tobias Saam1, Steven Soubron1, Josť G. Raya1, Katja Bochmann1, Markus Hacker2, Axel Rominger2, Peter Bartenstein2, Thomas Pfefferkorn3, Michael Dichgans3, Maximilian F. Reiser1, Konstantin Nikolaou1
Department of Clinical Radiology, University Hospitals Munich - Grosshadern, Munich, Germany; 2Department of Nuclear Medicine, University Hospitals Munich - Grosshadern, Munich, Germany; 3Department of Neurology, University Hospitals Munich - Grosshadern, Munich, Germany
    DCE-MRI was compared to the gold standard 18F-FDG-PET-CT for its applicability in the non-invasive quantification and measurement of arterial wall inflammation in patients with arteriitis in carotid and vertebral arteries. DCE-MRI of the carotid/vertebral arteries of 12 patients with suspected arteriitis was acquired at 3T (2D-SR-SGRE) using a dedicated 4-channel surface coil. Patients underwent 18F-FDG-PET-CT within one week of the MRI scan. Results showed a good correlation of DCE-MRI with 18F-FDG-PET-CT. This method might be useful in the diagnosis of arteriitis and in monitoring anti-inflammatory therapy.
11:06 602. Minimization of MR Contrast Weightings for the Comprehensive Evaluation of Carotid Atherosclerotic Disease
    Xihai Zhao1, Jianming Cai2, Hunter Underhill1, Minako Oikawa1, Li Dong1, Hideki Ota1, Thomas Hatsukami3, Chun Yuan1
Department of Radiology, University of Washington, Seattle, WA, USA; 2Department of Radiology, PLA General Hospital, Beijing, China; 3Department of Surgery, University of Washington, Seattle, WA, USA
    Multi-sequence MR imaging (TOF, T1W, PDW, and T2W) has been shown noninvasively characterizing carotid atherosclerosis. Although the use of these multiple contrast weightings can evaluate a spectrum of plaque features, each contrast weighting requires additional scan time and adds to the time required for image analysis. To minimize MR contrast weightings for the comprehensive evaluation of carotid atherosclerosis is potentially capable of reduce the scan time and cost. This study compared three MR contrast weighting combinations in evaluating carotid plaque features. The results showed that comprehensive carotid plaque interpretation can be performed with T1W, CE-T1W, and TOF sequences.
11:18 603. Multi-Spectral MRI Shows Unorganized Thrombus One Year After Endovascular Abdominal Aortic Aneurysm Repair
    Sandra Adriana Cornelissen1,2, Maarten J. van der Laan3, Koen L. Vincken4, Frans L. Moll3, Willem P. Mali1, Max A. Viergever2, Lambertus W. Bartels2
Radiology, UMC Utrecht, Utrecht, Netherlands; 2Image Sciences Institute, UMC Utrecht, Utrecht, Netherlands; 3Vascular Surgery, UMC Utrecht, Utrecht, Netherlands; 4Image Sciences Institute, UMC Utrecht, Netherlands
    Not all aneurysms without endoleak after endovascular abdominal aortic aneurysm repair (EVAR) shrink. In such cases it is unclear whether EVAR has been successful. Therefore it is important to further investigate this phenomenon. Apparently, more parameters are needed to evaluate treatment success. We present the first results of longitudinal monitoring of thrombus organization in patients after EVAR using multispectral MRI. Surprisingly, one year after EVAR unorganized thrombus is still present in the non-luminal aneurysm sac. Its etiology and significance is currently investigated in a larger population.
11:30 604. Thrombus Development and Fragmentation in Rats Using Non-Enhanced MRI
    Abdel Bidar1, Frank Risse1, Anna Ravnefjord2, Susanna Pehrsson2, Arno Nauerth3, Margareta Elg2, Paul D. Hockings1
DECS Imaging, AstraZeneca, Molndal, Sweden; 2BioScience, AstraZeneca, Molndal, Sweden; 3Bruker BioSpin, Ettlingen, Germany
    To our knowledge this is the first study to show the time course of thrombus formation over the first 4 days. Maximal average thrombus size was obtained 50 minutes after thrombus induction with no marked decrease over the following 4 days. Thrombus fragmentation was seen in several rats which potentially explains some of the variability seen in thrombosis models. An excellent correlation was found for MRI volume measurement and wet weight. MRI can follow thrombus formation, growth, fragmentation and dissolution in the same animal and thus drastically reduce the number of animals needed.
11:42 605. Comparison Between Three T1-Weighted Sequences for Detection and Area Measurement of Intraplaque Hemorrhage in Carotid Atherosclerotic Plaque Imaging at 3 Tesla
    Hideki Ota1, Vasily L. Yarnykh2, Marina S. Ferguson2, Hunter R. Underhill2, J Kevin DeMarco1, Minako Oikawa2, Li Dong2, Xihai Zhao2, David C. Zhu1, Thomas S. Hatsukami3, Chun Yuan2
Department of Radiology, Michigan State University, East Lansing, MI, USA; 2Department of Radiology, University of Washington, Seattle, WA, USA; 3Department of Surgery, University of Washington, Seattle, WA, USA
    In this study using a 3.0T scanner, the detection and area measurement of carotid intraplaque hemorrhage were compared amongst three T1W sequences: 2D-FSE, 3D-SPGR, and 3D-MPRAGE. For each T1W sequence, an experienced radiologist identified hemorrhage blinded to histology and the images and results from the other sequences. A total of 198 slices in 18 arteries were matched to histology. MPRAGE demonstrated the highest agreement for detection and quantification of hemorrhage with histology and the highest %-contrast of hemorrhage among 3 weightings. This study validates the use of MPRAGE as a fast and reliable hemorrhage-specific sequence for 3.0T carotid plaque MRI.
11:54 606. An Optimized 3D Spoiled Gradient for Hemorrhage Assessment Using INversion Recovery and Multiple Echoes (3D SHINE) for Carotid Plaque Imaging

David C. Zhu1, Hideki Ota, Anthony T. Vu2, J. Kevin DeMarco
1Psychology and Radiology, Michigan State University, East Lansing, MI, USA; 2GE Healthcare, Waukesha, WI, USA

    Intraplaque hemorrhage into the carotid atherosclerotic plaque has been shown to create instability and progression. We have developed an optimized 3D inversion recovery prepared fast spoiled gradient recalled sequence with multiple echoes, and is now characteristically called an optimized 3D Spoiled Gradient for Hemorrhage Assessment Using INversion Recovery and Multiple Echoes (3D SHINE) for carotid plaque imaging. The sequence has been further optimized in scan time, coverage and black-blood effect. Pilot patient data are presented. The T2* values appear to be promising in characterizing the hemorrhage type. This hemorrhage type characterization may provide additional information on plaque vulnerability.
12:06 607. Black Blood Vessel Wall Imaging of the Lower Extremities with T2prep Inversion Recovery: A Feasibility Study
    Thanh D. Nguyen1, Ryan Brown1, Matthew D. Cham1, Pascal Spincemaille1, Priscilla A. Winchester1, Grace Choi1, Martin R. Prince1, Yi Wang1
Radiology, Weill Cornell Medical College, New York, NY, USA
    Black blood techniques including double inversion recovery (DIR), spatial presaturation, and motion-sensitizing magnetization preparation perform well in elastic arteries with fast blood flow, but are less effective in the lower extremities where blood flow is substantially slower. The aim of this study is to optimize T2prep inversion recovery (T2IR) sequence, a novel flow-insensitive black blood technique, and to investigate the feasiblity of T2IR fast spin echo (FSE) for lower extremity vessel wall imaging with DIR-FSE as a reference. T2IR was found to provide improved robustness against slow flow artifacts at the cost of lower SNR. Vessel wall areas obtained with DIR-FSE and T2IR-FSE were comparable in both femoral (p=0.28) and popliteal (p=0.1) arteries.
12:18 608. Imaging the Vessel Wall in Major Peripheral Arteries Using Susceptibility Weighted Imaging: Visualizing Calcifications
    Qi Yang1, Jiangtao Liu1, Samuel Barnes2, Zhen Wu3, Kuncheng Li1, Jaladhar Neelavalli2, Jiani Hu2, E. M. Haacke2
Xuanwu hospital, Beijing, China; 2Wayne State University; 3McMaster University
    It is possible to image the vessel wall and calcifications with susceptibility weighted imaging (SWI) with no need to suppress the signal from the blood.