Weekday Educational Course:
Imaging Biomarkers 1 & 2
Organizers: H. Cecil Charles, Ph.D., and Jeffrey L. Evelhoch, Ph.D.
Skill Level: Basic
Wednesday, 22 April and Thursday, 23 April 2009
13:30 - 15:30

This course will introduce biomarker principles, how imaging is used as a biomarker in general and how imaging biomarkers are used in several specific diseases. It is comprised of two, two hour sessions with four presentations (followed by short question and answer periods) by scientists and physicians actively involved in the use of MR biomarkers in each session. The first session will provide a broad introduction to biomarkers (both imaging and non-imaging), how they are used, how they are qualified to be fit for their intended use and what is needed to implement MR biomarkers in a multi-center clinical trial. The second session will present examples of how imaging biomarkers (including, but not limited to MR) are used in multiple sclerosis, oncology, cardiovascular diseases and neurodegenerative diseases.
Upon completion of this case based session, participants should be able to:
  • Describe what a biomarker is and how magnetic resonance can be used as a biomarker;
  • Explain how biomarkers are qualified to be fit for their intended purpose;
  • Review what is required to use MR biomarkers in both preclinical studies and clinical trials; and
  • Give examples of how imaging biomarkers are being used in at least two of the following areas: multiple sclerosis, oncology, cardiovascular diseases and neurodegenerative diseases.

Wednesday, 22 April 2009
  Introduction to Imaging Biomarkers  
13:30 What Imaging Biomarkers Are and How They Are Used John C. Waterton, Ph.D.
14:00 Non-Imaging Biomarkers and Regulatory Aspects of Imaging Biomarkers Jeffrey L. Evelhoch, Ph.D.
14:30 Preclinical Applications of Imaging Biomarkers Markus von Kienlin, Ph.D.
15:00 Imaging Biomarkers in Neurodegenerative Diseases Clifford R. Jack, Jr., M.D.
15:30 Adjournment  
Thursday 24 April 2009
  Imaging Biomarkers in Practice  
13:30 Quantitative MR in Multi-Center Clinical Trials Edward Ashton, Ph.D.
14:00 Imaging Biomarkers in Multiple Sclerosis Massimo Filippi, M.D.
14:30 Imaging Biomarkers in Oncology Daniel C. Sullivan, M.D.
15:00 Imaging Biomarkers in Cardiovascular Disease Chun Yuan, Ph.D.
15:30 Adjournment