Weekend Educational Course:
Probing Cancer I: Molecular Pathways to Experimental Models
Organizers: Carles Arús, Ph.D. and Markus Rudin, Ph.D.
Skill Level: Intermediate
Saturday, 18 April 2009
08:30 - 17:30

This one day course is designed to introduce attendees to aspects of carcinogenesis and cancer physiology that are addressable by imaging. Our scientist teachers will cover tumor biology, imaging strategies to probe tumor ‘hallmarks’ eg: proliferation, metabolism, apoptosis, angiogenesis, etc; and use of imaging tools to demonstrate therapy efficacy. The overall goal of the course is to familiarize attendees with state-of-the-art tumor imaging using MRI techniques.
Upon completion of this case based session, participants should be able to:
  • Describe basic pathophysiology of cancer with specific to processes that are imaginable;
  • Explain the hallmarks and pathways of cancer and how they can be measured non-invasively;
  • Describe relationship between hypoxia, pH and radiation;
  • Compare roles that different imaging modalities can play in the characterization of preclinical cancer models; and
  • Define how imaging biomarkers may impact the development of cancer drugs.

Saturday, 18 April 2009
08:30 Tumor Biology Robert J. Gillies, Ph.D.
  Imaging General Tumor Hallmarks  
08:55 Proliferation – Imaging DNA, Protein, Membrane Synthesis Ross J. Maxwell, Ph.D.
09:40 Tumor Metabolism: MRS Studies John R. Griffiths, D.Phil.
10:15 Break - Meet the Teachers  
10:35 Acidosis Natarajan Raghunand, Ph.D.
11:10 PET - FDG and FLT Jeffrey L. Evelhoch, Ph.D.
11:45 Angiogenesis – Activated Endothelium Michal Neeman, Ph.D.
12:20 Break - Meet the Teachers  
13:45 Apoptosis Kevin M. Brindle, D.Phil.
  Imaging Gene Expression/ Tumor (Surface) Antigens  
14:20 Surface Receptors – Her2/neu Dmitri Artemov, Ph.D.
14:55 Reporter Gene Expression Assaf A. Gilad, Ph.D.
15:30 Break - Meet the Teachers  
  Evaluation of Therapy/ Biomarker  
16:00 Therapy Evaluation in Preclinical Models Martin O. Leach, Ph.D.
16:35 Techniques of Biomedical Imaging in Drug Discovery and Development Nicholas van Bruggen, Ph.D.
17:10 Adjournment - Meet the Teachers