Weekend Educational Course:
Cancer Magnetic Resonance Spectroscopy: Clinical and Research Applications
Organizers: N.R. Jagannathan, Ph.D. and Daniel B. Vigneron, Ph.D.
Skill Level: Intermediate
Sunday, 19 April 2009
08:30 - 17:30

This one day course focuses on cancer and MRS. It is designed for physicians (radiologists and oncologists) and for research scientists who wish to be updated on the current state-of-the-art in MRS techniques and clinical applications. The first part of the course will describe how MRS is used to evaluate cancers that occur in various body systems, and will also cover current efforts using MRS for cancer therapy planning and outcome assessment. The focus will be on clinical studies in human patients. This part of the course will introduce the basic technological underpinnings of MRS and discuss the biochemistry and metabolic features associated with signals that are detected with MRS. The second part will describe how MRS is used for the study of cancer-related animal models and tumor samples, and is intended to prepare participants for new cancer-related MRS applications that may emerge in the next few years.
Upon completion of this case based session, participants should be able to:
  • Discuss the basic MRS technology that is used in human cancer patients, animal models of cancer and tumor tissue samples;
  • Explain the specific biomarkers of cancer that can be measured with MRS;
  • Describe how MRS biomarkers of cancer are used for diagnosis of cancer, for therapy planning and for therapeutic outcome assessment; and
  • Describe how other imaging techniques relate to MRS biomarker assessment in cancer.

Sunday, 19 April 2009
  Part 1: Clinical MRS Applications  
08:30 Cancer Biology and Metabolism of Choline Compounds Franca Podo, D.Sc.
09:00 Introduction to MRS Techniques Jeffry R. Alger, Ph.D.
09:30 Evaluation of Brain Cancer with MRS Franklyn A. Howe, Ph.D.
10:00 Break - Meet the Teachers  
10:30 Evaluation of Prostate Cancer with MRS Tom W.J. Scheenen, Ph.D.
11:00 Evaluation of Breast Cancer with MRS N. R. Jagannathan, Ph.D.
11:30 MRS in Therapy Planning and Assessment of Therapy Response Sarah J. Nelson, Ph.D.
12:00 Break - Meet the Teachers  
  Part 2: Lipid Metabolism and Recent Advances  
13:30 MRS in the Study of Lipid Metabolism Chris Boesch, M.D., Ph.D.
14:00  Recent Advances in High-Field MRS and Other Techniques M. Albert Thomas, Ph.D.
  Part 3: MRS in Cancer Research  
14:30 Multinuclear MRS in Animal Models Zaver M. Bhujwalla, Ph.D.
15:00 Metabolic Studies of Cancer with Hyperpolarized Carbon-13 Daniel B. Vigneron, Ph.D.
15:30 Break - Meet the Teachers  
16:00 Evaluation of Tissue Samples by MRS Ingrid S. Gribbestad, Ph.D.
16:30 Metabolic Biomarkers in Cancer Cell Models Sabrina M. Ronen, Ph.D.
17:00 Metabolomics of Cancer by MRS John R. Griffiths, D. Phil.
17:30 Adjournment - Meet the Teachers