Weekend Educational Course:

MR Physics for Physicists 
Organizers: Michael H.
Buonocore, M.D., Ph.D., Michael Markl, Ph.D. and Lawrence L.
Wald, M.D., Ph.D. 

Skill Level:
Intermediate – Advanced 

Saturday, 18 April 2009 
08:30  18:00 

OVERVIEW 
This one day course will
explore the physical methods and mathematical models
that underlie nearly all research and development in MRI
and MR spectroscopy. Lectures will cover the general
topics of spin physics, signal detection, generation of
contrast, and imaging physics. 

Specific topics include:
 Quantum mechanical and semiclassical equations
for describing spin dynamics;
 The density matrix formalism and its
applications in MRS;
 Physical mechanisms of hyper polarization;
 Radiofrequency field equations and reciprocity
laws for signal detection;
 Sources of noise and limits to SNR;
 Tissue microstructure and molecular factors that
govern image contrast;
 Physical mechanism of exogenous and endogenous
contrast agents;
 Methods and models to describe magnetization
exchange;
 Physics and mathematics for susceptibility
weighted imaging;
 Mathematical description of dynamic equilibrium
in fast sequences;
 Calculation of effective relaxation times in
fast sequences;
 Applications of advanced electromagnetic theory
in imaging;
 Use of magnetization phase in applications;
 Methods for quantitative parameter mapping, and;
 Mathematical formalisms for RF pulse design.


EDUCATIONAL OBJECTIVES

Upon completion of this
course, participants should be able to:
 Describe and derive equations for spin and
magnetization dynamics, and list their main
applications;
 List physical mechanisms of spin relaxation and
polarization;
 Explain tissue microstructure responsible for
relaxation differences;
 Describe mathematical models used for
understanding image contrast generation and
parameter mapping; and
 Describe mathematical models used for RF pulse
design.



Saturday, 18 April 2009 




SPIN PHYSICS


08:30 
Quantum Mechanical
and SemiClassical Equations for Spin Dynamics 
Valerij
G. Kiselev, Ph.D. 
09:00 
The Density Matrix
Formalism and its Applications in MRS 
Thomas
Ernst, Ph.D. 
09:30 
Physical Mechanisms
for Hyperpolarization 
J.H.
ArdenkjaierLarsen, Ph.D. 




SIGNAL DETECTION


10:00 
Theory of RF
Reciprocity 
Greig C.
Scott, Ph.D. 
10:30 
Break  Meet the
Teachers 

10:50 
Sources of Noise and
Limits of SNR 
Klaas
Pruessmann, Ph.D. 




GENERATION OF
CONTRAST 

11:20 
Tissue
Microstructure and Molecular Factors that Govern MRI
Contrast 
Christopher C. Quarles, Ph.D. 
11:50 
Physical Mechanisms
of Contrast Agents 
Peter M.
Jakob, Ph.D. 
12:20 
Break  Meet the
Teachers 




13:40 
Physical Models for
Magnetization Exchange (Magnetization Transfer) 
Vasily
L. Yarnykh, Ph.D. 
14:10 
Physics and
Mathematics Challenges in Susceptibility Weighted
Imaging 
Jurgen
R. Reichenbach, Ph.D. 




IMAGING PHYSICS


14:40 
Mathematical
Description for Dynamic Equilibrium in Fast
Sequences 
Oliver
Bieri, Ph.D. 
15:10 
Calculation of
Effective Relaxation Times and Weighting in Fast
Sequences 
Matthias
Weigel, Ph.D. 
15:40 
Break  Meet the
Teachers 




16:00 
Applications of
Advanced Electromagnetic Theory 
Richard
W. Bowtell, Ph.D. 
16:30 
Use of Magnetization
Phase in Applications 
Oliver
Wieben, Ph.D. 
17:00 
Methods for
Quantitative Relaxation Parameter Mapping 
Paul S.
Tofts, Ph.D. 
17:30 
Mathematical
Formalisms for RF Pulse Design 
Adam B.
Kerr, Ph.D. 
18:00 
Adjournment  Meet
the Teachers 






