Sunrise Course:
From Bench to Bedside to Bench: Translation of Animal Models to Clinical Practice & From Clinical Practice to Animal Models
Organizers: Pia C. Maly Sundgren, M.D., Ph.D., and Afonso C. Silva, Ph.D.
 
Skill Level: Intermediate
Tuesday - Friday, 4-7 May 2010
07:00 - 08:00

OVERVIEW
In this four-hour course, each session will focus on the translation of animal work to clinical practice and vice versa, and the use of MRI to diagnose, estimate or get a deeper insight in the outcome of the following pathologies:
  • Traumatic brain injury (TBI)
  • Polycystic kidney disease (PCKD)
  • Multiple sclerosis (MS)
  • Oncology Imaging (OI)
Experimental findings and clinical work will be discussed separately and combined in each session. The two speakers will fine tune their findings to provide a full picture of what is feasible and what is already translated to the clinical work-up, and also how the clinical practice might translate into animal models and improve insight into disease patho-physiology.
 
EDUCATIONAL OBJECTIVES
Upon completion of this course participants should be able to:
  • Describe the main MRI methods used in experimental studies to understand the underlying disease mechanisms;
  • Identify what is known about the underlying disease mechanisms, and which type of MRI investigations could be used for diagnosis and clinical investigation;
  • Describe the main MRI methods used in the clinical setting to diagnose the condition, and the rationale behind this; and
  • Make the translation from what is - and can be - done in experimental studies to what can be done clinically, and where animal models bring new insight to disease.

Tuesday Traumatic Brain Injury  
  Moderators: Pia C. Maly Sundgren, M.D., Ph.D., and Afonso C. Silva, Ph.D.
07:00 MRI Assessment of Cerebral Blood Flow & Macrophage Accumulation in Mouse Models for Traumatic Brain Injury Lesley May Foley, B.Sc.
07:30 Translation of Traumatic Brain Injury into Human & Clinical Practice Susan Durham, M.D.
08:00 Adjournment  
     
Wednesday Polycystic Kidney Disease  
  Moderators: Diana M. Gomez-Hassan, M.D., Ph.D., and Afonso C. Silva, Ph.D.
07:00 Mouse Models for Polycystic Kidney Disease Ralph Witzgall, Ph.D.
07:30 Polycystic Kidney Disease and MRI Arlene B. Chapman, M.D.
08:00 Adjournment  
     
Thursday Oncology Imaging  
  Moderators: Pia C. Maly Sundgren, M.D., Ph.D., and Afonso C. Silva, Ph.D.
07:00 Multimodality Radionuclide, Fluorescence, Bioluminescence Small-Animal Imaging Including Animal Models for DCE-MRI & DWI MRI - not available Jinha M. Park, M.D., Ph.D.
07:30 Multimodality In-Vivo Molecular & Advanced Oncologic Imaging: Human Metrics/Applications Where is the Animal Model Validation? Meng Law, M.D.,M.B.B.S., F.R.A.C.R.
08:00 Adjournment  
     
Friday Multiple Sclerosis  
  Moderators: Diana M. Gomez-Hassan, M.D., Ph.D., and Afonso C. Silva, Ph.D.
07:00 MRI Tracking of Stem Cells in Multiple Sclerosis Vincent Dousset, M.D.
07:30 Connectivity in MS Tarek Yousry, M.D.
08:00 Adjournment  
     

 

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