Weekend Educational Course:
Advanced Neuroimaging I & II
Clinical Intensive Education Option
Organizers: Nicola de Stefano, M.D., Ph.D., Patricia Ellen Grant, M.D., M.Sc., Micheal D. Phillips, M.D., Stefan Sunaert, M.D., Ph.D., and Mark A. Van Buchem, M.D., Ph.D.
Skill Level: Basic - Intermediate
Saturday, 1 May and Sunday, 2 May 2010

This two-day course aims to give the participant a better understanding of advanced neuro imaging techniques and their application in both clinical and research settings. Speakers will be Ph.D. researchers and clinician scientists. The course will be taught in a didactic format with time for discussion after each talk and ample time provided between sessions to meet the teachers and ask questions. Day 1 will be directed at specific techniques and their applications, including perfusion, diffusion, functional MRI, susceptibility weighted imaging and MR-based morphometry. Day 2 will focus on application of these techniques to specific neuronal processes and disease states, including brain development, brain tumors, cerebrovascular disease and Parkinson's disease. The overall goal of the course is to provide an in-depth understanding of state-of-the-art advanced neuro imaging techniques which serve as tools both in the research setting as well as everyday clinical practice.
Upon completion of this course participants should be able to:
  • Describe multiple methods for obtaining perfusion information from MR images and evaluate their relative value to answer specific clinical or research questions;
  • Explain current thinking regarding the relationship between diffusion measurements and underlying brain physiology;
  • Explain current thinking and controversies regarding the relationship between electrophysiology and BOLD signal on fMRI as well as potential issues in fMRI related to neurovascular coupling;
  • Describe the underlying principles involved in susceptibility weighted imaging as well as potential applications in specific disease processes;
  • Evaluate different methods of performing MR morphometry as well as their potential application and validity in the clinical setting;
  • Explain and contrast utility of currently available techniques for the evaluation of changes in the developing brain;
  • Explain and implement state-of-the-art imaging techniques for the diagnosis and evaluation of brain tumors;
  • Describe current thinking regarding the relationship between MR imaging changes and underlying cerebral vascular disease; and
  • Describe current imaging methods for diagnosis, monitoring, and image-guided therapy for Parkinson's disease.

Saturday, May 1
Advanced Neuroimaging I
09:00 Perfusion Imaging: How Does It Work & What Should I Use Joseph A. Maldjian, M.D.
09:30 Perfusion & BBB: Blessing or Curse? Meng Law, M.D., M.B.B.S., F.R.A.C.R.
10:00 Perfusion Imaging: What Are We Seeing? Marco Essig, M.D., Ph.D.
10:30 Break  
  10:30 - 10:45 Meet the Teachers  
11:00 Diffusion : A Window on Histology & Physiology? Jeffrey J. Neil, M.D., Ph.D.
11:30 Do We Need Tractography in the Clinic? Marco Catani, M.D.
12:00 Tips, Tricks and Pitfalls Stephen E. Jones, M.D.
12:30 Break  
  12:30 - 12:45 Meet the Teachers  
14:00 What Do We Known About Brain Function Today: Relationship of Electrophysiology to BOLD David A. Leopold, Ph.D.
14:30 Neurovascular Coupling & Uncoupling Alberto Bizzi, M.D.
15:00 Clinical Brain Mapping: How fMRI & DTI Play Together - not available John L. Ulmer, M.D.
15:30 Break  
  15:30 - 15:45 Meet the Teachers  
16:00 SWI and Phase Imaging: Astronomy of Black Holes? Kathryn E. Hammond Rosenbluth, Ph.D.
16:30 Is Black Bad? About Tips, Tricks & Artifacts Bejoy Thomas, M.D.
17:00 Volumetry & VBM Measurements Stephen M. Smith, D.Phil.
17:20 Clinical Use of Volumetry Nicola de Stefano, M.D., Ph.D.
17:40 Clinical Use of VBM Maria A. Rocca, M.D.
18:00 Adjournment  
  18:00 - 18:15 Meet the Teachers  
Sunday, 2 May
Advanced Neuroimaging II
  Brain Development  
08:15 The Brain in the Belly: What & How of Fetal Neuro-Imaging Nadine J. Girard, M.D.
08:45 The Nascent Brain: Patterns & Mechanism of Brain Injury At Birth Patricia Ellen Grant, M.D., M.Sc.
09:15 Neural Plasticity- Queen & Servant of Cognitive Neuroscience Stephanie Clarke, Ph.D.
09:45 Break  
  09:45 - 10:00 Meet the Teachers  
10:15 A Tumor on T2! What Now & Next?  Elias R. Melhem, M.D., Ph.D.
10:45 Preoperative Assessment: What the Surgeon Needs To Know? Andreas Bartsch, M.D.
11:15 Tensor What? Everything You Were Afraid to Ask Pratik Mukherjee, M.D., Ph.D.
11:45 Radiation Necrosis: What Do We Have to Make a Confident Diagnosis? Pia C. Maly Sundgren, M.D., Ph.D.
12:15 Break  
  12:15 - 12:30 Meet the Teachers  
  Cerebrovascular Disease  
13:30 Large Vessels, Major Improvements Aad van der Lugt, M.D., Ph.D.
14:00 Small Vessels, Big Problems Mark A. Van Buchem, M.D., Ph.D.
14:30 Age Related White Matter Hyperintensities: Age Spots Revisited Howard A. Rowley, M.D.
15:00 Break  
  15:00 - 15:15 Meet the Teachers  
  Parkinson's Disease  
15:30 Functional Anatomy of Movement Benjamin L. Walter, M.D.
16:00 Imaging Non-Motor Symptoms Stephane Lehéricy, M.D., Ph.D.
16:30 Movement Disorders: Role of Imaging in Diagnosis Mario Mascalchi, M.D. 
17:00 Movement Disorders: Role of Imaging in Treatment: Individualized Treatment Micheal D. Phillips, M.D.
17:30 Adjournment  
  17:30 - 17:45 Meet the Teachers  

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