Weekend Educational Course:
Molecular & Cellular Imaging
Organizers: Jeffrey W. M. Bulte, Ph.D., and Anna V. Moore, Ph.D.
Skill Level: Intermediate - Advanced
Sunday, 2 May 2010

This one-day course is designed for graduate students, postdoctoral scientists, and physicians (radiologists) who are either new to this field or wish to be updated on the current state of the art in molecular and cellular imaging applications. The first part of the course will describe how contrast agents can be used to endow cells with MR-visible properties, and then how this enables tracking of stem cells and immune cells in various disease models. Different molecular probes will be described, of which some can provide contrast with other modalities. We will also cover combining these probes with therapeutic drugs in targeting of surface receptors, and issues with translating molecular imaging from small rodents to large animal models. Finally, the regulatory issues and current pitfalls that exist with clinical translation will be outlined in detail.
Upon completion of this course participants should be able to:
  • Describe the historical milestones that have lead to the current status of the field;
  • Describe several drawbacks for each class of MR contrast agents;
  • Describe pharmacokinetic profiles of targeted contrast agents;
  • Explain pitfalls associated with the quantification of molecular and cellular targets;
  • List clinical MRI cell tracking trials; and
  • Identify the factors that are important for the safety and clinical approval of molecular imaging.

08:30 History of Molecular Imaging Angelique Louie, Ph.D.
09:00 PFC-Based Cell Tracking - not available Eric T. Ahrens, Ph.D.
09:30 SPIO-Based Cell Tracking Erik M. Shapiro, Ph.D.
10:00 Break  
  10:00 - 10:15 Meet the Teachers  
10:30  Theragnostic Capsules - not available Dara L. Kraitchman, V.M.D., Ph.D.
11:00 Reporter Genes Keren Ziv, Ph.D.
11:30 Multimodal Nanoparticles Willem M. Mulder, Ph.D.
12:00 Break  
  12:00 - 12:15 - Meet the Teachers  
13:30 Novel Imaging Techniques Peter M. Jakob, Ph.D.
14:00 Quantification Approaches Brian K. Rutt, Ph.D.
14:30 Multilabeling of Differential Targets Silvio Aime, Ph.D.
15:00 Break  
  15:00 - 15:15 Meet the Teachers  
15:30 Challenges in Imaging Large Species Anna V. Moore, Ph.D.
16:00 What Is Needed for Clinical Approval? Adrian D. Nunn, Ph.D.
16:30 Fibrin Imaging: A Clinical Example Peter Caravan, Ph.D.
17:00 Adjournment  
  17:00 - 17:15 - Meet the Teachers  


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