Weekend Educational Course:
Preclinical MR of Cancer
Organizers: Carles Arús, Ph.D., and Sabrina M. Ronen, Ph.D.
Skill Level: Basic - Intermediate
Saturday, 1 May 2010

This one-day course focuses on cancer in preclinical models and integrates MR imaging, MR spectroscopy and MR spectroscopic imaging studies. It is designed for research scientists and physicians (radiologists and oncologists) who wish to be updated on the current state of the art in MR techniques for the investigation of preclinical models. Accordingly, most of the speakers will be PhDs. The first part of the course will be geared to beginners, and will describe the basic ‘how to’ aspects of a range of preclinical methods in different types of models. The second part of the course will be geared to beginners/intermediates, and will cover the application of the methods outlined in part one to preclinical cancer research. It will cover well-established applications and emerging state-of-the-art approaches. Thus it is hoped that the second part of the course will also prepare participants for new cancer-related MR applications that may emerge in the next few years.
Upon completion of this course participants should be able to:
  • Recognize the basic MRI, MRS and MRSI technologies which should be available in state-of-the art spectrometers for preclinical cancer research studies, including studies of cells, tissue samples and animal models;
  • Identify potential pitfalls and methodological requirements for carrying adequate preclinical MR studies of cancer;
  • List recognized biomarkers of cancer accessible from preclinical MR studies of cancer models;
  • Describe the principal applications of basic MRI, MRS and MRSI technologies in preclinical cancer research studies;
  • Select MRI, MRS and MRSI biomarkers of cancer to use for modeling diagnosis, therapy planning and therapeutic outcome assessment; and
  • Recognize the added value of multiparametric biomarker analysis in preclinical MR of cancer.

08:30 How to Study in Cancer Cell Models E. Jim Delikatny, Ph.D.
09:00 How to Perform HR-MAS Studies in Tissue Ingrid S. Gribbestad, Ph.D.
09:30 How to Do MRS/MRSI in Animal Models Arend Heerschap, Ph.D.
10:00 Break  
  10:00 - 10:15 Meet the Teachers  
10:30 How to Perform MRI in Animal Models Chantal Rémy, Ph.D.
11:00 Obtaining & Presenting Multi-Parametric Biomarker Data John Kurhanewicz, Ph.D.
11:30 Choline in Cancer Kristine Glunde, Ph.D.
12:00 Break  
  12:00 - 12:15 - Meet the Teachers  
13:30 Neutral Lipids in Cancer Juhana M. Hakumäki, M.D.
14:00 Energy Metabolism in Cancer  - not available Carles Arús, Ph.D.
14:30 pH in Cancer Sebastián Cerdán, Ph.D.
15:00 Break  
  15:00 - 15:15 Meet the Teachers  
15:30 Vasculature in Cancer Hagit Dafni, Ph.D.
16:00 Diffusion in Cancer Thomas L. Chenevert, Ph.D.
16:30 Drug Delivery & Response in Cancer Yuen-Li Chung, Ph.D.
17:00 Adjournment  
  17:00 - 17:15 - Meet the Teachers  


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