Cancer: Multi Modal Imaging Including PRI/MRI
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Friday May 13th
Room 518-A-C  10:30 - 12:30 Moderators: Zahi A. Fayad and Martin O. Leach

10:30 754.   Introduction
Zahi A. Fayad


10:42 755.   FDG-PET imaging with first combined Whole-Body MR-PET vs. conventional PET/CT: qualitative and quantitative comparison of results 
1Translational and Molecular Imaging Institute, Mount Sinai School of Medicine, NEW YORK, NY, United States, 2Department of Cardiology, Zena and Michael A. Weiner Cardiovascular Institute, Mount Sinai School of Medicine, NEW YORK, NY, United States, 3Department of Cardiology, Marie-Josée and Henry R. Kravis Cardiovascular Health Center, Mount Sinai School of Medicine, NEW YORK, NY, United States, 4Philips Healthcare, CLEVELAND, OH, United States, 5Philips Healthcare, CLEVELAND, United States,6Division of Nuclear Medicine, Department of Radiology, Mount Sinai School of Medicine, NEW YORK, NY, United States

The objective of this study is to evaluate the performance of the new combined Whole-Body MR-PET scanner in terms of a qualitative and quantitative analysis compared to a conventional clinical PET/CT scanner. 15 patients were scanned on the combined Whole-Body MR-PET scanner (Philips) immediately following a clinical PET/CT scanner (GE DLS) to allow comparison of the images. The results on this study show a high correlation between SUV mean and max values (r = 0.91 and r= 0.97, p<0.0001 respectively). These results reflect the possibilities of FDG-PET imaging with the combined MR-PET scanner compared with a conventional PET/CT system.

10:54 756.   The Effect of MR Acoustic Noise on FDG-PET Uptake in a Simultaneous MR/PET System 
Daniel Burje Chonde1,2, Nasreddin Abolmaali3, Alma Gregory Sorensen1, and Ciprian Catana1
1Athinoula A. Martinos Center for Biomedical Imaging, Charlestown, MA, United States, 2Department of Biophysics, Harvard University, Cambridge, MA, 3OncoRay - Center for Radiation Research in Oncology, Dresden, Germany

Simultaneous MRI and PET imaging for clinical application has recently become feasible. While significant work has been done to limit hardware interference, less has been done to explore potential physiologic interference. This study explores the impact of MR acoustic noise on FDP-PET uptake in the human auditory cortex. Healthy volunteers were injected with 5 mCi of FDG and dynamic PET imaging was performed for 40 minutes using the BrainPET in the presence and absence of simultaneously acquired MR. Static 40 to 60 minute frames were also examined. No significant change was noted in either the PET data or the PET detector performance.

11:06 757.   Comparison of Diffusion Weighted Imaging with [18F]-FLT Uptake in a Human Colon Cancer Xenograft Model using Treatment Strategies 
Valerie Simone Honndorf1, Sally-Ann Ricketts2, Jane Halliday2, Hans F. Wehrl1, Stefan Wiehr1, Damaris Kukuk1, Maren K. Koenig1, Mareike Lehnhoff1, Julia Mannheim1, Gerald Reischl3, and Bernd J. Pichler1
1Laboratory for Preclinical Imaging and Imaging Technology of the Werner Siemens-Foundation, University of Tuebingen, Tuebingen, Germany, 2Imaging, Translational Sciences, AstraZeneca, Alderley Park, Macclesfield, Cheshire, United Kingdom, 3Radiopharmacy and PET-Center, University of Tuebingen, Tuebingen, Germany

Diffusion-weighted MRI in combination with PET is a powerful tool to monitor cancer therapy. We show the correlation between the [18F]FLT-PET imaging and the apparent diffusion coefficient (ADC) in a colon cancer mouse model in a control group and a group treated with docetaxel. We found that the ADC maps reveal an inverse spatial correlation to the [18F]FLT uptake in the tumor demonstrating the relationship between water diffusion in necrotic regions and the thymidine kinase activity in proliferating cells. Such complementarities between MR diffusivity and [18F]FLT-PET open new insights for the usability of diffusion-weighted imaging as diagnostic tool in oncology.

11:18 758.   Multi-scale Imaging of Angiogenesis in a Breast Cancer Model 
Jana Cebulla1,2, Eugene Kim3, Jiangyang Zhang4, and Arvind P. Pathak5
1University Halle-Wittenberg, Halle, Germany, 2Johns Hopkins University School of Medicine, Baltimore, MD, United States, 3Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, United States, 4Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University Shool of Medicine, Baltimore, MD, United States, 5JHU ICMIC Program, Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University, Baltimore, MD, United States

Multi-scale characterization of angiogenesis in pre-clinical breast cancer models helps elucidate its role in tumor progression and facilitates investigations into the systems biology of angiogenesis. By imaging the tumor vasculature with three independent methods (in vivo MRI, ex vivo micro-CT and MR-microscopy), we acquired complementary data that yields information about tumor angiogenesis at different spatial scales. The extracted vasculature and fractional blood volume maps computed from these complementary datasets showed excellent agreement over all spatial scales. In addition to characterizing breast cancer angiogenesis, we use these multi-scale data in biophysical models of MR image contrast, and computational models of angiogenesis.

11:30 759.   Multimodal Imaging of a Dual PI3K/mTOR Inhibitor Demonstrates Strong Effects on Vascular Function 
Shelby Katherine Wyatt1, Kai H Barck1, Jason R Oeh2, Hani Bou-Reslan1, Tim C Cao1, Hartmut Koeppen3, Lori S Friedman2, Deepak Sampath2, and Richard A. D. Carano1
1Biomedical Imaging, Genentech, Inc, South San Francisco, CA, United States, 2Translational Oncology, Genentech, Inc, South San Francisco, CA, United States,3Pathology, Genentech, Inc, South San Francisco, CA, United States

Multispectral (MS)-DCE-MRI and DCE-ultrasound studies were performed to assess the PI3K/mTORi effects on vascular function. MS-DCE-MRI demonstrated tumor growth suppression, Ktrans reduction, and suggests potential vp changes, while DCE-US demonstrated a decrease in blood flow and enhancement factor following PI3K/mTORi. These responses are consistent with vasoconstriction as well as vessel density reduction. These results help elucidate PI3K/mTORi effects on tumor vasculature function and advocate the use of MS-DCE-MRI and DCE-US as biomarkers for similar therapies.

11:42 760.   Molecular imaging of breast lesions with PET-MRI: proof of concept 
Katja Pinker1, Stephan Gruber1, Wolfgang Bogner1, Siegfried Trattnig1, and Thomas H Helbich1
1Department of Radiology, Medical University Vienna, Vienna, Vienna, Austria

To demonstrate the feasibility of combined 3T contrast-enhanced MRI and 18FDG-PET-CT for molecular imaging of breast lesions and to assess possible increase in diagnostic sensitivity and specificity. 31 breast lesions were examined with 18FDG-PET-CT and 3T MRI of the breast, classified according to BIRADS and histopathologically verified. Sensitivity and specificity of PET-MRI was 100% and 100% respectively. Molecular imaging of breast lesions with PET-MRI is feasible. PET-MRI seems to improve diagnostic confidence in the diagnosis of breast lesions and enables accurate assessment of nodal status.

11:54 761.   Whole body PET-MRI scanner: first experience in oncology 
Osman Ratib1, Magalie Viallon2, Habib Zaidi1, Minerva Becker3, Jean-Paul Vallée4, Michael Wissmeyer1, Jean-pierre Willi1, Pierre Loubeyre5, Navdeep Ojha6, Piotr Maniawski6, and Christoph Becker3
1Nuclear Medicine, Hopital Universitaire de Genève, GENEVE, Switzerland, 2Radiology, Hopital Universitaire de Genève, GENEVA, Switzerland, 3Radiology, Hopital Universitaire de Genève, GENEVE, Switzerland, 4Radiology, Hopital Universitaire de Genève, 5Breast Oncology, Hopital Universitaire de Genève, GENEVE, Switzerland,6Philips Healthcare, Cleveland, United States

A prototype hybrid PET-MR scanner for sequential whole body scanning was implemented and tested to evaluate the performance and clinical applicability for oncology. The device consists of a 3T MR and a time-of-flight PET scanner sharing a single bed allowing sequential acquisition of co-registered images. 64 patients were scanned following a routine clinical PET/CT study. Optimized imaging protocols allowing full diagnostic quality of both modalities while reducing the total time of the study were developed. Clinical interpretation of PET-MR studies were compared to those of PET-CT. Results showed similar diagnostic accuracy in detection and localization of focal lesions and tumors. Whole-body MR attenuation scans were insufficient for accurate anatomical lesion localization comparable and additional high resolution MR sequences were needed.

12:06 762.   Diffusion Weighted MR Imaging: Predictive Capability for Chemoradiotherapeutic Effect in Non-Small Cell Lung Cancer Patients as Compared with FDG-PET/CT 
Keiko Matsumoto1, Yoshiharu Ohno2, Hisanobu Koyama2, Takeshi Yoshikawa2, Mizuho Nishio2, Yumiko Onishi2, Nobukazu Aoyama3, Daisuke Takenaka2, and Kazuro Sugimura2
1Radiology, Yamanashi Hospital of Social Insurance, Kofu, Yamanashi, Japan, 2Radiology, Kobe University Graduate School of Medicine, Kobe, Hyogo, Japan, 3Radiology, Kobe University Hospital, Kobe, Hyogo, Japan

To the best of our knowledge, the capability of diffusion-weighted MR imaging (DWI) for prediction of therapeutic effect in advanced non-small cell carcinoma (NSCLC) patients with chemoradiotherapy as not yet been demonstrated. In the present study, we hypothesized that quantitatively assessed DWI can be utilized for prediction of therapeutic effect after chemoradiotherapy in NSCLC patients as well as FDG-PET/CT. Thus, the purpose of the present study was to directly and prospectively compare the predictive capability for therapeutic effect of chemoradiotherapy between DWI and FDG-PET/CT in NSCLC patients.

12:18 763.   Combined use of DWI, DCE-MRI, and PET/CT in treatment response for preoperative chemoradiation in primary rectal adenocarcinoma 
Jing Gu1, Tao Chan1, Wailun LAW2, JingBo Zhang3, and Pek-Lan Khong1
1Diagnostic Radiology, The University of Hong Kong, Hong Kong, China, People's Republic of, 2Colorectal Surgery, Queen Mary Hospital, The University of Hong Kong, Hong Kong, China, People's Republic of, 3Radiology, Memorial Sloan-Kettering Cancer Center, United States

As functional imaging modalities, DWI, DCE-MRI, and PET/CT have been applied in monitoring treatment response. However, the underlying biophysical basis for changes of imaging parameters during a course of chemoradiation therapy (CRT) is far from fully understood. An increase of apparent diffusion coefficient (ADC), a quantitative parameter from DWI, suggests treatment-induced cell lysis and necrosis. However, increase in ADC can also result from change in vessel permeability due to radiation therapy. For this, DCE-MRI may provide useful information. On the other hand, late decrease in ADC can be considered result of tissue compaction and fibrosis or presence of residual active disease, which may be distinguished by PET/CT. So the aim of this study was to investigate DWI, DCE-MRI and PET/CT for response assessment over a course of pre-operative combined CRT for primary rectal adenocarcinoma, to see if the combination of different techniques can best predict biological behavior and clinical outcome.