Microstructural Imaging Techniques in the Brain
ORGANIZERS: Daniel C. Alexander, Ph.D. & Geoffrey J. M. Parker, Ph.D.
SKILL LEVEL: Intermediate-Advanced
Sunday, 6 May 2012

A range of MR methods exist that help provide an understanding of the microscopic geometry of tissues (such as estimates of axon diameter) and related tissue composition (for example the quantification of myelin density). In addition to providing a general view of this rapidly developing area and its impact on neuroscience, this half-day course will focus on different data acquisition and analysis methods that are relevant to studying microstructure.

Brief introductions to each area covered will be given, in addition to detailed descriptions of the available methods for probing microstructure. This will include discussion of theory, data acquisition, data analysis and modeling, and the underlying neuroscience.
Upon completion of this course participants should be able to:
Recommend appropriate MR contrast mechanisms for probing brain microstructure;
Select MR acquisition and analysis methods that are able to quantify aspects of brain microstructure;
Describe the potential and limitations of existing methods; and
Explain the impact of MR microstructure measurements on neuroscience.
This course is designed for scientists and clinicians who are currently working with or have an interest in quantitative MRI neuroimaging and who are want to learn about possibilities for quantification of cerebral tissues at the microscopic level. The course assumes knowledge of basic cerebral tissue composition and MR methods, and a working knowledge of neuroscience, MR data acquisition and analysis methods.


Click on to view the abstract pdf. Click on to view the recorded presentation.

  Moderators: Daniel C. Alexander, Ph.D. & Geoffrey J. M. Parker, Ph.D.
08:00 Scene Setting & Motivation Christian Beaulieu, Ph.D.
08:30 What Contrasts Can We Use to Probe Microstructure? Mark D. Does, Ph.D.
09:00 qMT Mara Cercignani, Ph.D.
09:30 Relaxivity Measurements Alex L. MacKay, Ph.D.
10:00 Break - Meet the Teachers  
10:30 Diffusion Acquisitions for Microstructure Tim B. Dyrby, Ph.D.
11:00 Modeling of Diffusion MRI Victor Sheng-Kwei Song, Ph.D.
11:30 Impact on Neuroscience Christopher D. Kroenke, Ph.D.
12:00 Adjournment  
  12:00-12:15 Meet the Teachers