Everything You Wanted to Know about Contrast Agents
ORGANIZERS: Roland Bammer, Ph.D. & Bachir Taouli, M.D.
SKILL LEVEL: Intermediate-Advanced
Sunday, 6 May 2012

This one-day course will cover the basics of MR and cellular contrast media, including chemical structure and MR physical properties, as well as potential emerging clinical applications of contrast agents. Specifically, the following topics will be covered:
Contrast agent structure and MR physical properties;
Contrast agent safety;
Contrast agent cost and regulation;
Contrast tracer kinetics;
Iron oxides and paramagnetic nanoparticles;
Cellular Labeling; and
CEST Agents and hyperpolarized agents.
Upon completion of this course participants should be able to:
Describe structure and physical properties of pre-clinical and clinical MR contrast agents;
Evaluate safety and risks of MR contrast agents;
Describe the approval and regulation processes for MR contrast agents;
Explain current models and applications of MR contrast tracer kinetics;
Describe structure and potential usage of iron oxides and paramagnetic nanoparticles; and
List and explain current uses of cellular labeling, CEST and hyperpolarized agents.
This course is designed for intermediate to advanced chemists and physicists with an interest in molecular imaging, clinical MRI and drug trials. No particular experience is needed, and current work may include lab or research environment, drug trials.


Click on to view the abstract pdf. Click on to view the recorded presentation.
  Moderators: Roland Bammer, Ph.D. & Bachir Taouli, M.D.  
08:00 Contrast Agents 101: How Do Gd, Dy, Mn, Iron Particles & the Structure/Size of the Chelate alter Relaxation Times? Val M. Runge, M.D.
08:20 A Mole for the Moles: How to Compute Dose & Other Stuff You Missed in High School Joel R. Garbow, Ph.D.
08:40 Is Your Agent Charge-Neutral, Linear, Cyclic or Albuminbinding? - All You Wanted to Know about Chelates, Macromolecules & their Differences Henrik S. Thomsen, M.D.
09:00 All I Need to Know about Contrast Safety: Dissociation, Transmetalation, Renal Excretion/Insufficiency, Toxicity & Reporting Incidences
permission withheld
Martin R. Prince, M.D., Ph.D.
09:20 Why Is It so Darn Difficult to Get More Imaging Drugs? -- A Glimpse on Approval, Trials, Costs, Safety, Generics & PMA Sunder S. Rajan, Ph.D.
09:40 Tracer Kinetics: Understand Your Own Model without Breaking Out those Scary Differential Equations Steven P. Sourbron, Ph.D.
10:00 The Irons in Your Fire: Iron Oxide Particles & Paramagnetic Nanoparticles Gregory M. Lanza, M.D., Ph.D.
10:20 Break - Meet the Teachers  
11:00 Cellular Labeling: Transfection Mechanisms & MR Reporter Genes Jeff W. M. Bulte, Ph.D.
11:20 CEST Agents & pH Sensitive Probes: How Do They Work & What's Their Potential A. Dean Sherry, Ph.D.
11:40 MEMRI & Responsive Agents Alan P. Koretsky, Ph.D.
12:00 Build Your Own C13 Shack: An Absolute Beginner's Guide to (Pre)Clinical Hyperpolarized Agents Daniel M. Spielman, Ph.D.
12:20 Adjournment  
  12:20-12:35 Meet the Teachers