Functional Connectivity of the Brain
ORGANIZERS: Xiaoping P. Hu, Ph.D. & Fa-Hsuan Lin, Ph.D.
SKILL LEVEL: Basic-Intermediate
Sunday, 6 May 2012

This four-hour half-day course is designed to introduce theory and applications of functional as well as effective connectivity of the brain. Scientists and clinicians interested in connectivity will learn about neurophysiological basis of connectivity, definitions and derivations of effective connectivity using Structural Equation Modeling and causal modeling, and functional connectivity pre-processing, analysis, and validation. Representative application of the connectivity analysis to clinical medicine will also be presented. The connectivity topics covered in this course can be viewed as the extension after understanding functional MRI data acquisition and analysis to identify activated brain areas during tasks, cognition, and rest in order to further elucidate the non-directional and directional modulations among these areas. Neurophysiological basis and clinical applications of these connectivity analyses will be also covered in the lectures. Presentations will be followed by a break to meet the lecturers for interactive discussion.
Upon completion of this course participants should be able to:
Describe the neurophysiological basis of connectivity;
Differentiate between functional and effective connectivity;
Analyze functional MRI data to assess directional modulations using Structural Equation Modeling;
Describe the theory and the challenges of causality modeling using functional MRI data;
Prepare MRI data to improve the sensitivity and reliability of functional connectivity analysis;
Ascertain functional connectivity using seed and Independent Component Analysis methods;
Correlate the functional connectivity with neurophysiology and structure; and
Describe opportunities and challenges of applying connectivity analysis to clinical practice.
This course is designed for scientists and clinicians who are starting to work in the field of brain functional and/or effective connectivity and would like to have an overview of the scientific and technical underpinnings of these techniques. The course assumes a basic knowledge of functional MRI, but not necessarily familiarity with the technical details, neurophysiological basis, or clinical opportunities of connectivity analysis of functional MRI data to reveal correlated and/or causal modulations between different areas of the brain during tasks and rest.


Click on to view the abstract pdf. Click on to view the recorded presentation.

  Moderators: Xiaoping P. Hu, Ph.D. & Fa-Hsuan Lin, Ph.D.  
13:30 Neurophysiological Basis of Connectivity Michael Breakspear, Ph.D., M.B.B.S.
  Effective Connectivity  
14:00 Structural Equation Modeling Stephen C. Strother, Ph.D.
14:30 Casual Modeling Alard F. Roebroeck, Ph.D.
15:00 Break - Meet the Teachers  
  Functional Connectivity  
15:30 Pre-Processing Catherine E. Chang, Ph.D.
16:00 Seed & ICA Analyses
permission withheld
James J. Pekar, Ph.D.
16:30 Validation & Correlation Amir Shmuel, Ph.D.
17:00 Connectivity in Practice Michael P. Milham, M.D., Ph.D.
17:30 Adjournment  
  17:30-17:45 Meet the Teachers